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    Clinical uses and survival study of free and encapsulated probiotic bacteria in fruit juices: A review

    , Article Applied Food Biotechnology ; Volume 8, Issue 3 , 2021 , Pages 161-179 ; 23455357 (ISSN) Alemzadeh, I ; Afarin, M ; Dehghan, A ; Sani, M. A ; Teimouri, M ; Seilani, F ; Abbasi, P ; Vaziri, A. S ; Sharif University of Technology
    National Nutrition and Food Technology Research Institute  2021
    Background and Objective: Probiotics are dietary supplements with potential health benefits for humans when consumed regularly at appropriate quantities. The latest evidence shows possible beneficial effects of probiotics in COVID-19 treatment. Interests in probiotic consumption have led to provide products such as probiotic juices with vitamins, minerals, prebiotics and appropriate levels of probiotics to the market in free and encapsulated forms, which are not fully addressed in scientific literatures. The objective of this review was to investigate effects of probiotics for the management of human health. Other objectives included study on effects of free and encapsulated forms of... 

    Polymeric carriers for enhanced delivery of probiotics

    , Article Advanced Drug Delivery Reviews ; Volume 161-162 , 2020 , Pages 1-21 Asgari, S ; Pourjavadi, A ; Licht, T. R ; Boisen, A ; Ajalloueian, F ; Sharif University of Technology
    Elsevier B.V  2020
    Probiotics are live microorganisms (usually bacteria), which are defined by their ability to confer health benefits to the host, if administered adequately. Probiotics are not only used as health supplements but have also been applied in various attempts to prevent and treat gastrointestinal (GI) and non-gastrointestinal diseases such as diarrhea, colon cancer, obesity, diabetes, and inflammation. One of the challenges in the use of probiotics is putative loss of viability by the time of administration. It can be due to procedures that the probiotic products go through during fabrication, storage, or administration. Biocompatible and biodegradable polymers with specific moieties or pH/enzyme... 

    Optimization of Encapsulation of Probiotic Living Cells

    , M.Sc. Thesis Sharif University of Technology Sajjadi Dehkordi, Sahar (Author) ; Alemzadeh, Iran (Supervisor)
    In the recent year, there has been a rising interest in producing functional foods containing encapsulated probiotic bacteria according to their perceived health benefits. Probiotics are feed and food supplements that beneficially affect the host’s health. The term “probiotic” includes a large range of microorganisms, mainly lactic acid bacteria. Because they can stay alive until the intestine and provide health beneficial effects like lowering cholesterol, improving lactose tolerance and preventing some cancers like colon cancer on the host health. It has been recommended that the viability of probiotics should be at least 107 CFU/ml of product at time of consumptions to provide selective... 

    Determination of Micro Encapsulation of Probiotic

    , M.Sc. Thesis Sharif University of Technology Najafizadeh, Mobarakeh (Author) ; Alemzadeh, Iran (Supervisor)
    Probiotics are defined as essential live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. In order to provide health benefits for probiotic bacteria it has been recommended that they must be present at a minimum level of 106 CFU/g of food product or 107 CFU/g at point of delivery or be eaten in sufficient amounts to yield a daily intake of 108 CFU. Several studies have shown that certain strain of lactic acid bacteria, such as Bifidobacterium bifidum and Lactobacillus acidophilus prevent some diseases linked to the gastro-intestinal tract. however, many reports have demonstrated their poor survival and stability. Their survival in the... 

    Design of a Colorimetric Sensor Array Based on Aggregation of Gold Nanoparticles on the Surface of Probiotic Bacteria for Identification and Discrimination of Antiseptic Alcohols

    , M.Sc. Thesis Sharif University of Technology Ghamsari, Mahdi (Author) ; Hormozinezhad, Mohammad Reza (Supervisor)
    The occurrence of the COVID-19 pandemic and the subsequent rising demand for purchasing alcohol-based sanitizers led to a remarkable prosperity in supplying these hygiene products. Hence, the development of a straightforward and efficient analytical strategy for discrimination of antiseptic alcohols including methanol, ethanol and isopropanol is of great importance. By exploiting the alcohol-sensitive membranes of probiotic bacteria, this research aims to develop a colorimetric sensor array for discriminating methanol, ethanol and isopropanol. In this design, the aggregation of citrate-capped gold nanoparticles (Au NPs) on the thiol-modified surface of two probiotic bacteria, including... 

    Co-microencapsulation of lactobacillus plantarum and DHA fatty acid in alginate-pectin-gelatin biocomposites

    , Article Carbohydrate Polymers ; Volume 199 , 2018 , Pages 266-275 ; 01448617 (ISSN) Vaziri, A. S ; Alemzadeh, I ; Vossoughi, M ; Chackoshian Khorasani, A ; Sharif University of Technology
    The aim of this study was to investigate the co-microencapsulation of Lactobacillus plantarum and DHA-rich oil in a novel gastrointestinal-resistant biocomposite composed of alginate, pectin and gelatin. The optimal biocomposite consisted of 1.06% alginate, 0.55% pectin and 0.39% gelatin showed 88.66% survivability of the microencapsulated cells compared to the free cells (50.36%). In addition, co-microencapsule containing probiotic and DHA fatty acid was synthesized and physicochemically analyzed using SEM, FTIR, TGA, XRD. The results from SEM clearly confirmed that cells were completely entrapped in the matrix and DHA increased smoothness and compactness of the surface of the particles.... 

    Prevention of gestational diabetes mellitus (GDM) and probiotics: Mechanism of action: A review

    , Article Current Diabetes Reviews ; Volume 16, Issue 6 , 2020 , Pages 538-545 Homayouni, A ; Bagheri, N ; Mohammad Alizadeh Charandabi, S ; Kashani, N ; Mobaraki Asl, N ; Mirghafurvand, M ; Asgharian, H ; Ansari, F ; Pourjafar, H ; Sharif University of Technology
    Bentham Science Publishers  2020
    Background: Gestational Diabetes Mellitus (GDM) is a health problem that is increasing around the world. Introduction: Prevention of GDM, rather than treatment, could have several benefits in terms of both health and economic cost. Even a slight reduction in maternal glucose in non-diabetic women, particularly in women at high risk for GDM, may have significant benefits for pregnancy results and the future health of off-springs. Probiotics are a relatively new intervention, which are assessed by mothers’ metabolism, and can reduce blood sugar levels, prevent gestational diabetes and reduce the maternal and fetal complications resulting from it. The aim of this study was to review the studies... 

    The immunomodulatory effects of probiotics on respiratory viral infections: A hint for COVID-19 treatment?

    , Article Microbial Pathogenesis ; Volume 148 , November , 2020 Mahooti, M ; Miri, S. M ; Abdolalipour, E ; Ghaemi, A ; Sharif University of Technology
    Academic Press  2020
    Respiratory virus infections are among the most prevalent diseases in humans and contribute to morbidity and mortality in all age groups. Moreover, since they can evolve fast and cross the species barrier, some of these viruses, such as influenza A and coronaviruses, have sometimes caused epidemics or pandemics and were associated with more serious clinical diseases and even mortality. The recently identified Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a Public Health Emergency of International concern and has been associated with rapidly progressive pneumonia. To ensure protection against emerging respiratory tract... 

    Co-microencapsulation of Probiotic Bacteria and DHA Fatty Acid; Optimization and Evaluation of the Viability of Probiotic and Oxidative Stability of DHA during Gastrointestinal Tract

    , M.Sc. Thesis Sharif University of Technology Vaziri, Asma Sadat (Author) ; Alemzadeh, Iran (Supervisor) ; Vossoughi, Manouchehr (Supervisor)
    Due to the increased public awareness about the role of food on health, an increased interest of consuming fortified food has grown rapidly. Probiotic bacteria and DHA poly-unsaturated fatty acid are two major bioactive ingredients becoming increasingly popular in food fortification industry due to their beneficial effects. However, high susceptibility of probiotic bacteria during production, maintenance and digestion in acidic and enzymatic conditions of gastrointestinal tract results in decreasing the survivability and therefore reducing health effects in body. Besides, having multiple double bonds in the structure of DHA fatty acid leads to oxidative degradation that produces volatile... 

    Optimization of alginate-whey protein isolate microcapsules for survivability and release behavior of probiotic bacteria

    , Article Applied Biochemistry and Biotechnology ; Volume 190, Issue 1 , 2020 , Pages 182-196 Sajadi Dehkordi, S ; Alemzadeh, I ; Vaziri, A. S ; Vossoughi, A ; Sharif University of Technology
    Springer  2020
    The present study aimed to improve the survivability of L. acidophilus encapsulated in alginate-whey protein isolate (AL-WPI) biocomposite under simulated gastric juice (SGJ) and simulated intestinal juice (SIJ). Microcapsules were prepared based on emulsification/internal gelation technique. Optimal compositions of AL and WPI and their ratio in the aqueous phase were evaluated based on minimizing mean diameter (MD) of the microcapsules and maximizing encapsulation efficiency (EE), survivability of cells under SGJ (Viability), and release of viable cells under SIJ (Release) using Box-Behnken experimental design. Optimal composition comprising 4.54% (w/v) AL, 10% (w/v) WPI, and 10% (v/v)...