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Dose-dependent effects of nanoscale graphene oxide on reproduction capability of mammals
, Article Carbon ; Volume 95 , December , 2015 , Pages 309-317 ; 00086223 (ISSN) ; Ghaderi, E ; Hashemi, E ; Akbari, E ; Sharif University of Technology
Elsevier Ltd
2015
Abstract
In vivo dose-dependent effects of nanoscale graphene oxide (NGO) sheets on reproduction capability of Balb/C mice were investigated. Biodistribution study of the NGO sheets (intravenously injected into male mice at dose of ∼2000 μg/mL or 4 mg/kg of body weight) showed a high graphene uptake in testis. Hence, in vivo effects of the NGO sheets on important characteristics of spermatozoa (including their viability, morphology, kinetics, DNA damage and chromosomal aberration) were evaluated. Significant in vivo effects was found at the injected concentrations ≥200 μg/mL after (e.g., ∼45% reduction in sperm viability and motility at 2000 μg/mL). Observation of remarkable DNA fragmentations and...