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Study of Antimicrobial Properties For Propolis
, M.Sc. Thesis Sharif University of Technology ; Roostaazad, Reza (Supervisor) ; Bayat, Farhad (Co-Advisor)
Abstract
Propolis is a resin compound which is collected from different Plant sources by bees. It is processed by salivary enzymes and is combined with wax bee and is used in hives, Specially in entrance door. In this study Propolis is selected as a natural substance. The aim of this study is to change the substance to get use of in industry. For this, first, antimicrobial properties of it was proved and then for industrial use encapsulation was done to keep the capability of it. Since propolis extract was prepared with 70% ethanol, and the encapsulation was done with the polymer-effective material ratio of 5,0,1,2 by a proper polymer with no bad effect on the body. Later an appropriate powder was...
Bioactive Packaging Study to Improve the Quality of Food Products
, M.Sc. Thesis Sharif University of Technology ; Roostaazad, Reza (Supervisor)
Abstract
One of the most important concerns in food industry is decreasing the contamination of food and increasing their shelf life. Antimicrobial/antioxidant packaging, an active packaging concept, can be considered an extremely challenging technology that could have a significant impact on shelf-life extension and food safety of meat and meat products. Due to harmfulness of chemical preservatives, their use has been limited and therefore natural antimicrobial/antioxidant agents have become more popular. Propolis is a natural resinous substance, with a high polyphenol content, produced by honeybees and characterized by antimicrobial, anti-inflammatory and antioxidant properties, which make it...
Preparation and investigation the release behaviour of wax microspheres loaded with salicylic acid
, Article Journal of Microencapsulation ; Volume 26, Issue 6 , 2009 , Pages 485-492 ; 02652048 (ISSN) ; Taghizadeh, M ; Seifkordi, A. A ; Ardjmand, M ; Sharif University of Technology
2009
Abstract
Salicylic acid-beeswax microspheres were prepared by melt dispersion technique. The effects of formulation parameters on the microscopic characteristic, drug loading and cumulative amount of released drug were investigated by experimental design. Results showed that all of the microparticles were spherical with porous surfaces. The average size of microspheres was 2448 m, the drug content was in the range of 2245 and the encapsulation efficiency was 4693. Drug loading was influenced by emulsification speed as a main factor. All the microspheres had a burst release initially. The emulsifier concentration did not have a significant effect on drug release. The release behaviour of microspheres...
Preparation and characterization of poly-lactic acid based films containing propolis ethanolic extract to be used in dry meat sausage packaging
, Article Journal of Food Science and Technology ; Volume 57, Issue 4 , 2020 , Pages 1242-1250 ; Roosta Azad, R ; Sharif University of Technology
Springer
2020
Abstract
In this study, active poly lactic acid (PLA) films containing 0, 10, 20 and 40% w/w propolis extract (PE), as active agent, were developed. A high amount of phenolic content (PC) was measured in PE. The antioxidant effect of active PLA films was determined by measuring the PC of sausage slices after 0, 2 and 4 days storage at refrigerator. Results showed that phenolic compounds of PE were released from PLA films in quantities proportional to PE concentration. Disc diffusion test indicated that PE showed an inhibitory effect against Staphylococcus aureus and Pseudomonas aeruginosa bacterial species but was more effective against gram-positive species. PE containing PLA films had antimicrobial...
Involvement of TGF-β and autophagy pathways in pathogenesis of diabetes: a comprehensive review on biological and pharmacological insights
, Article Frontiers in Pharmacology ; Volume 11 , 15 September , 2020 ; Sajadimajd, S ; Mirzarazi, E ; Haratipour, P ; Joshi, T ; Farzaei, M. H ; Khan, H ; Echeverria, J ; Sharif University of Technology
Frontiers Media S.A
2020
Abstract
Despite recent advancements in clinical drugs, diabetes treatment still needs further progress. As such, ongoing research has attempted to determine the precise molecular mechanisms of the disorder. Specifically, evidence supports that several signaling pathways play pivotal roles in the development of diabetes. However, the exact molecular mechanisms of diabetes still need to be explored. This study examines exciting new hallmarks for the strict involvement of autophagy and TGF-β signaling pathways in the pathogenesis of diabetes and the design of novel therapeutic strategies. Dysregulated autophagy in pancreatic β cells due to hyperglycemia, oxidative stress, and inflammation is associated...