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    Design and fabrication of an electrochemical-based nanofibrous immunosensor for detection of prostate cancer biomarker, PSMA

    , Article Polymers for Advanced Technologies ; Volume 33, Issue 6 , 2022 , Pages 1967-1977 ; 10427147 (ISSN) Rezaei, Z ; Alemzadeh, I ; Vossoughi, M ; Sharif University of Technology
    John Wiley and Sons Ltd  2022
    Abstract
    Convenient medical diagnostics and treatments can replace conventional healthcare procedures because of their fast and profitable applications with reduced infection risk. Meanwhile, early diagnosis of cancer is a leading research subject due to the high fatality rate of the disease and being a vital precursor in the treatment effectiveness. Electrochemical-based micro-biosensors are the best candidates for measuring particular biomarker concentrations in body fluids. To address this need, we used a simple fabrication approach to develop an effective immunosensor for the early detection of cancer, in particular prostate cancer. The carbon fibers, obtained from the electrospinning technique,... 

    An Algorithm for Analyzing the Spatial Distribution of the Evolutionary Development Processes

    , M.Sc. Thesis Sharif University of Technology Moradi, Davoud (Author) ; Foroughmand-Araabi, Mohammad Hadi (Supervisor)
    Abstract
    Evolutionary processes are the process of change in one or more physical and heritable characteristics that result from the occurrence of genetic changes (beneficial, harmful, or neutral) over time, and ultimately from generation to generation, depending on natural selection. Cancer is a genetic disease that occurs as a result of an evolutionary process by the somatic cells and examining the spatial characteristics of cancer can help understanding it. It is also important to examine the spatial configuration of cells considering their access to limiting factors such as nutrients and adequate space. In addition, paying attention to the gene expression, individually and collectively, will help... 

    Designing and Fabrication of Microfluidic Biosensor by DNA-Directed Immobilization

    , Ph.D. Dissertation Sharif University of Technology Esmaeili, Elaheh (Author) ; Vossoughi, Manouchehr (Supervisor) ; Soleimani, Masoud (Supervisor) ; Shamloo, Amir (Supervisor)
    Abstract
    The present study is aimed at the development of a novel approach based on the magnetically improvement of DNA-directed immobilization to prepare a highly efficient sensor for prostate diagnosis. The novelty of this work is in the use of antibody conjugated magnetic nanoparticles via DDI. DNA-modified magnetic nanoparticles are added in solution to capture DNA-conjugated, fluorescently-labeled immunocomplexes formed in solution free of steric constraints. The DDI-based nanoconstructs are then concentrated and immobilized using a magnetic field. Compared to a process in which the immunocomplex directly forms on the sensing surface, the proposed approach provides higher mass transfer and lower... 

    An Investigation on the Parameters Affecting Electrochemical Biosensors Performance to Detect Prostate Cancer

    , M.Sc. Thesis Sharif University of Technology Saghafi, Mohammad Javad (Author) ; Abdekhodaie, Mohammad Jafar (Supervisor)
    Abstract
    Early detection of prostate cancer using biosensors has been a subject of research for nearly two decades due to its critical importance. The timing of detection plays a crucial role in determining treatment success rates. However, a significant limitation of these studies has been the cost and limited sensitivity of the sensors. In this research, various treatments used in biosensors were compared and necessary parameters to develop a sensitive, low-cost sensor have been subject of optimization. For this reason, we used pencil graphite and graphite sheet electrodes, both of which have potential for low-cost production on a large scale. Additionally, we tested graphene oxide, amine-treated... 

    Fuzzy Control of Percutaneous Needle Using Ultrasound Imaging-Based
    Trajectory Planning

    , M.Sc. Thesis Sharif University of Technology Kariminik, Mitra (Author) ; Jahed, Mehran (Supervisor)
    Abstract
    Subcutaneous needle insertion is one of the key methods of limited invasive surgery in medical diagnosis and treatment. However, errors in needle targeting can reduce the effectiveness of such efforts. One of the main factors of errors is due to the human guidance of the needle, which many researches have approached in recent years, and among the suggested solutions is the use of automatic or semi-automatic assist systems. Considering the treatment of prostate cancer by brachytherapy method, this research has developed a semi-automatic physician assistance system using navigation based on the potential field method and ultrasound images of the needle location, and sliding mode fuzzy... 

    A novel ensemble strategy for classification of prostate cancer protein mass spectra

    , Article 29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07, Lyon, 23 August 2007 through 26 August 2007 ; 2007 , Pages 5987-5990 ; 05891019 (ISSN) ; 1424407885 (ISBN); 9781424407880 (ISBN) Assareh, A ; Moradi, M. H ; Esmaeili, V ; Sharif University of Technology
    2007
    Abstract
    Protein mass spectra pattern recognition is a new forum in which many machine learning algorithms have been conducted to enhance the chance of early cancer diagnosis. The high-dimensionality-small-sample (HDSS) problem of cancer proteomic datasets still requires more sophisticated approaches to improve the classification accuracy. In this study we present a simple ensemble strategy based on measuring the generalizing capability of different subsets of training data and apply it in making final decision. Using a limited number of biomarkers along with 5 classification algorithms, the proposed method achieved a promising performance over a well-known prostate cancer mass spectroscopy dataset.... 

    Recent advancements in aptamer-bioconjugates: Sharpening stones for breast and prostate cancers targeting

    , Article Journal of Drug Delivery Science and Technology ; Volume 53 , 2019 ; 17732247 (ISSN) Maghsoudi, S ; Shahraki, B. T ; Rabiee, N ; Afshari, R ; Fatahi, Y ; Dinarvand, R ; Ahmadi, S ; Bagherzadeh, M ; Rabiee, M ; Tahriri, M ; Tayebi, L ; Sharif University of Technology
    Editions de Sante  2019
    Abstract
    Breast and prostate cancers are common types of cancers with various strategies, such as chemotherapy and radiotherapy, for their therapy. Since these methods have undesired side effects and poor target affinity, neoteric strategies—known as aptamer-based smart drug delivery systems (SDDSs)—have been developed in recent years to overcome the obstacles of current treatment, and investigated for a clinical trial. The high affinity and versatility of aptamers for binding to the corresponding targets make them highly noticeable agents in the drug delivery domains. In addition to their exceptional benefits, aptamers are able to overcome tumor resistance because of their high selectivity and low... 

    Using Body Fluids for Early Prostate Cancer Detection

    , M.Sc. Thesis Sharif University of Technology Jalali Dowlatshahi, Sayeh (Author) ; Abdekhodaie, Mohammad Jafar (Supervisor)
    Abstract
    Today, despite the notable progress in diagnostics and therapeutics, cancer remains the second cause of death worldwide. This rather high mortality rate is often attributed to cancers diagnosed at late stages, including prostate cancer. Among the techniques approved for prostate cancer diagnosis, total or free prostate-specific antigen screening using blood serum samples is the sole method able to detect prostate cancer at an early stage. This test has led to a significant decrease in prostate cancer-related deaths. Nonetheless, it possesses several drawbacks, such as the complex, costly, and time-consuming conventional methods utilized in clinical laboratories to assess the concentration of... 

    Mathematical Modeling of 188Re-PSMA in Rats and its Human Absorbed dose Estimation

    , M.Sc. Thesis Sharif University of Technology Hadisi, Maliheh (Author) ; Vosoughi, Naser (Supervisor) ; Yousefnia, Hassan (Supervisor) ; Bahrami Samani, Ali (Co-Supervisor)
    Abstract
    Prostate cancer is the second most common cancer in men and the fourth leading cause of death in the world. In this study, the 188Re-HYNIC-PSMA radiolabeled compound was produced as a compound for use in the treatment of prostate cancer and its metastases under optimal labeling conditions and its radiochemical purity was obtained above 98% using RTLC and HPLC chromatographic methods. This compound is stable at room temperature and in human blood serum for at least 48 hours after preparation. The biological distribution of this compound was investigated in each rat tissue and the amount of injected activity per unit mass of each tissue (%ID/g) was determined. The bio-distribution of 188... 

    Zinc ferrite spinel-graphene in magneto-photothermal therapy of cancer

    , Article Journal of Materials Chemistry B ; Vol. 2, Issue. 21 , 2014 , p. 3306-3314 Akhavan, O ; Meidanchi, A ; Ghaderi, E ; Khoei, S ; Sharif University of Technology
    Abstract
    A magneto-photothermal therapy for cancer (in vitro photothermal therapy of prostate cancer cells and in vivo photothermal therapy of human glioblastoma tumors in the presence of an external magnetic field) was developed using superparamagnetic zinc ferrite spinel (ZnFe2O4)-reduced graphene oxide (rGO) nanostructures (with various graphene contents). In vitro application of a low concentration (10 μg mL-1) of the ZnFe 2O4-rGO (20 wt%) nanostructures under a short time period (∼1 min) of near-infrared (NIR) irradiation (with a laser power of 7.5 W cm-2) resulted in an excellent destruction of the prostate cancer cells, in the presence of a magnetic field (∼1 Tesla) used for localizing the... 

    Towards automatic prostate gleason grading via deep convolutional neural networks

    , Article 5th Iranian Conference on Signal Processing and Intelligent Systems, ICSPIS 2019, 18 December 2019 through 19 December 2019 ; 2019 ; 9781728153506 (ISBN) Khani, A. A ; Fatemi Jahromi, S. A ; Otroshi Shahreza, H ; Behroozi, H ; Baghshah, M. S ; Sharif University of Technology
    Institute of Electrical and Electronics Engineers Inc  2019
    Abstract
    Prostate Cancer has become one of the deadliest cancers among males in many nations. Pathologists use various approaches for the detection and the staging of prostate cancer. Microscopic inspection of biopsy tissues is the most accurate approach among them. The Gleason grading system is used to evaluate the stage of Prostate Cancer using prostate biopsy samples. The task of assigning a grade to each region in a tissue is a time-consuming task. Furthermore, this task often has several challenges since it has considerable inter-observer variability even among expert pathologists. In this paper, we propose an automatic method for this task using a deep learningbased approach. For this purpose,... 

    Optimization of the Dose Distribution in the Brachytherapy Using the Genetic Algorithm in Order to Increase the Absorbed Dose in the Cancer Tumor and to Reduce It in the Healthy Tissues

    , M.Sc. Thesis Sharif University of Technology Naderi, Hossein (Author) ; Hosseini, Abolfazl (Supervisor)
    Abstract
    Prostate cancer is the second most common cancer in men and the fourth most common cancer in all cancers. Cancer treatment is done according to the type of cancer and its diagnosis stage with different treatment methods and plans. Brachytherapy is one of the most common methods of cancer treatment along with teletherapy, surgery and chemotherapy. In this method, the source of radiation is located near or inside the tumor, and its advantage is to achieve a lower dose ratio of healthy tissue to the tumor is lower compared to teletherapy. One of the challenges in brachytherapy is to prescribe the appropriate treatment plan for the patient, so that the maximum dose of sources reaches the... 

    The use of a glucose-reduced graphene oxide suspension for photothermal cancer therapy

    , Article Journal of Materials Chemistry ; Volume 22, Issue 27 , 2012 , Pages 13773-13781 ; 09599428 (ISSN) Akhavan, O ; Ghaderi, E ; Aghayee, S ; Fereydooni, Y ; Talebi, A ; Sharif University of Technology
    RSC  2012
    Abstract
    A single-step green method for effective reduction and functionalization of graphene oxide (GO) by glucose was developed. Then, efficacy of the glucose-reduced GO sheets in photothermal therapy of LNCaP prostate cancer cells was investigated in vitro. The GO suspension reduced and functionalized by glucose in the presence of Fe catalyst showed a biocompatible property with an excellent near-infrared (NIR) photothermal therapy efficiency better than hydrazine-reduced GO, single-wall and multi-wall carbon nanotube suspensions which even showed some levels of toxicities. For complete destruction of the cancer cells at some time intervals of NIR irradiation (e.g., 0.5 and 12 min with a power... 

    ZnFe2O4 nanoparticles as radiosensitizers in radiotherapy of human prostate cancer cells

    , Article Materials Science and Engineering C ; Volume 46 , January , 2015 , Pages 394-399 ; 09284931 (ISSN) Meidanchi, A ; Akhavan, O ; Khoei, S ; Shokri, A. A ; Hajikarimi, Z ; Khansari, N ; Sharif University of Technology
    Elsevier Ltd  2015
    Abstract
    Nanoparticles of high-Z elements exhibit stronger photoelectric effects than soft tissues under gamma irradiation. Hence, they can be used as effective radiosensitizers for increasing the efficiency of current radiotherapy. In this work, superparamagnetic zinc ferrite spinel (ZnFe2O4) nanoparticles were synthesized by a hydrothermal reaction method and used as radiosensitizers in cancer therapy. The magnetic nanoparticles showed fast separation from solutions (e.g., ~ 1 min for 2 mg mL- 1 of the nanoparticles in ethanol) by applying an external magnetic field (~ 1 T). The ZnFe2O4 nanoparticles were applied in an in vitro radiotherapy of lymph node carcinoma of prostate cells (as high... 

    Assessment and comparison of اomogeneity and conformity indexes in step-and-shoot and compensator-based intensity modulated radiation therapy (IMRT) and three-dimensional conformal radiation therapy (3D CRT) in prostate cancer

    , Article Journal of Medical Signals and Sensors ; Volume 7, Issue 2 , 2017 , Pages 102-107 ; 22287477 (ISSN) Salimi, M ; Shirani Tak Abi, K ; Nedaie, H. A ; Hassani, H ; Gharaati, H ; Samei, M ; Shahi, R ; Zarei, H ; Sharif University of Technology
    Abstract
    Intensity modulated radiation therapy (IMRT) and three-dimensional conformal radiation therapy (3D CRT) are two treatment modalities in prostate cancer, which provide acceptable dose distribution in tumor region with sparing the surrounding normal tissues. IMRT is based on inverse planning optimization; in which, intensity of beams is modified by using multileaf collimators and also compensators with optimum shapes in step and shoot (SAS) and compensator-based method, respectively. In the recent study, some important parameters were compared in two IMRT and 3D CRT methods. Prescribed dose was 80 Gy for both IMRT procedures and 70 Gy for 3D CRT. Treatment plans of 15 prostate cancer... 

    Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 29 cancer groups, 1990 to 2017: a systematic analysis for the global burden of disease study

    , Article JAMA Oncology ; Volume 5, Issue 12 , 2019 , Pages 1749-1768 ; 23742437 (ISSN) Fitzmaurice, C ; Abate, D ; Abbasi, N ; Abbastabar, H ; Abd Allah, F ; Abdel Rahman, O ; Abdelalim, A ; Abdoli, A ; Abdollahpour, I ; Abdulle, A. S. M ; Abebe, N. D ; Abraha, H. N ; Abu Raddad, L. J ; Abualhasan, A ; Adedeji, I. A ; Advani, S. M ; Afarideh, M ; Afshari, M ; Aghaali, M ; Agius, D ; Agrawal, S ; Ahmadi, A ; Ahmadian, E ; Ahmadpour, E ; Ahmed, M. B ; Akbari, M. E ; Akinyemiju, T ; Al Aly, Z ; Alabdulkader, A. M ; Alahdab, F ; Alam, T ; Alamene, G. M ; Alemnew, B. T. T ; Alene, K. A ; Alinia, C ; Alipour, V ; Aljunid, S. M ; Bakeshei, F. A ; Almadi, M. A. H ; Almasi Hashiani, A ; Alsharif, U ; Alsowaidi, S ; Alvis Guzman, N ; Amini, E ; Amini, S ; Amoako, Y. A ; Anbari, Z ; Anber, N. H ; Andrei, C. L ; Anjomshoa, M ; Ansari, F ; Ansariadi, A ; Appiah, S. C. Y ; Arab Zozani, M ; Arabloo, J ; Arefi, Z ; Aremu, O ; Areri, H. A ; Artaman, A ; Asayesh, H ; Asfaw, E. T ; Ashagre, A. F ; Assadi, R ; Ataeinia, B ; Atalay, H. T ; Ataro, Z ; Atique, S ; Ausloos, M ; Avila Burgos, L ; Avokpaho, E. F. G. A ; Awasthi, A ; Awoke, N ; Ayala Quintanilla, B. P ; Ayanore, M. A ; Ayele, H. T ; Babaee, E ; Bacha, U ; Badawi, A ; Bagherzadeh, M ; Bagli, E ; Balakrishnan, S ; Balouchi, A ; Barnighausen, T. W ; Battista, R. J ; Behzadifar, M ; Behzadifar, M ; Bekele, B. B ; Belay, Y. B ; Belayneh, Y. M ; Berfield, K. K. S ; Berhane, A ; Bernabe, E ; Beuran, M ; Bhakta, N ; Bhattacharyya, K ; Biadgo, B ; Bijani, A ; Bin Sayeed, M. S ; Birungi, C ; Bisignano, C ; Bitew, H ; Bjorge, T ; Bleyer, A ; Bogale, K. A ; Bojia, H. A ; Borzi, A. M ; Bosetti, C ; Bou Orm, I. R ; Brenner, H ; Brewer, J. D ; Briko, A. N ; Briko, N. I ; Bustamante-Teixeira, M. T ; Butt, Z. A ; Carreras, G ; Carrero, J. J ; Carvalho, F ; Castro, C ; Castro, F ; Catala Lopez, F ; Cerin, E ; Chaiah, Y ; Chanie, W. F ; Chattu, V. K ; Chaturvedi, P ; Chauhan, N. S ; Chehrazi, M ; Chiang, P. P. C ; Chichiabellu, T. Y ; Chido Amajuoyi, O. G ; Chimed Ochir, O ; Choi, J. Y. J ; Christopher, D. J ; Chu, D. T ; Constantin, M. M ; Costa, V. M ; Crocetti, E ; Crowe, C. S ; Curado, M. P ; Dahlawi, S. M. A ; Damiani, G ; Darwish, A. H ; Daryani, A ; Das Neves, J ; Demeke, F. M ; Demis, A. B ; Demissie, B. W ; Demoz, G. T ; Denova Gutierrez, E ; Derakhshani, A ; Deribe, K. S ; Desai, R ; Desalegn, B. B ; Desta, M ; Dey, S ; Dharmaratne, S. D ; Dhimal, M ; Diaz, D ; Dinberu, M. T. T ; Djalalinia, S ; Doku, D. T ; Drake, T. M ; Dubey, M ; Dubljanin, E ; Duken, E. E ; Ebrahimi, H ; Effiong, A ; Eftekhari, A ; El Sayed, I ; Zaki, M. E. S ; El Jaafary, S. I ; El Khatib, Z ; Elemineh, D. A ; Elkout, H ; Ellenbogen, R. G ; Elsharkawy, A ; Emamian, M. H ; Endalew, D. A ; Endries, A. Y ; Eshrati, B ; Fadhil, I ; Fallah, V ; Faramarzi, M ; Farhangi, M. A ; Farioli, A ; Farzadfar, F ; Fentahun, N ; Fernandes, E ; Feyissa, G. T ; Filip, I ; Fischer, F ; Fisher, J. L ; Force, L. M ; Foroutan, M ; Freitas, M ; Fukumoto, T ; Futran, N. D ; Gallus, S ; Gankpe, F. G ; Gayesa, R. T ; Gebrehiwot, T. T ; Gebremeskel, G. G ; Gedefaw, G. A ; Gelaw, B. K ; Geta, B ; Getachew, S ; Gezae, K. E ; Ghafourifard, M ; Ghajar, A ; Ghashghaee, A ; Gholamian, A ; Gill, P.S ; Ginindza, T. T. G ; Girmay, A ; Gizaw, M ; Gomez, R. S ; Gopalani, S. V ; Gorini, G ; Goulart, B. N. G ; Grada, A ; Ribeiro Guerra, M ; Guimaraes, A.L.S ; Gupta, P. C ; Gupta, R ; Hadkhale, K ; Haj Mirzaian, A ; Hamadeh, R. R ; Hamidi, S ; Hanfore, L. K ; Haro, J. M ; Hasankhani, M ; Hasanzadeh, A ; Hassen, H. Y ; Hay, R. J ; Hay, S. I ; Henok, A ; Henry, N. J ; Herteliu, C ; Hidru, H. D ; Hoang, C. L ; Hole, M. K ; Hoogar, P ; Horita, N ; Hosgood, H. D ; Hosseini, M ; Hosseinzadeh, M ; Hostiuc, M ; Hostiuc, S ; Househ, M ; Hussen, M. M ; Ileanu, B ; Ilic, M.D ; Innos, K ; Irvani, S. S. N ; Iseh, K. R ; Islam, S. M. S ; Islami, F ; Jafari Balalami, N ; Jafarinia, M ; Jahangiry, L ; Jahani, M. A ; Jahanmehr, N ; Jakovljevic, M ; James, S.L ; Javanbakht, M ; Jayaraman, S ; Jee, S. H ; Jenabi, E ; Jha, R. P ; Jonas, J. B ; Jonnagaddala, J ; Joo, T ; Jungari, S. B ; Jurisson, M ; Kabir, A ; Kamangar, F ; Karch, A ; Karimi, N ; Karimian, A ; Kasaeian, A ; Kasahun, G. G ; Kassa, B ; Kassa, T. D ; Kassaw, M. W ; Kaul, A ; Keiyoro, P. N ; Kelbore, A. G ; Kerbo, A. A ; Khader, Y. S ; Khalilarjmandi, M ; Khan, E. A ; Khan, G ; Khang, Y. H ; Khatab, K ; Khater, A ; Khayamzadeh, M ; Khazaee Pool, M ; Khazaei, S ; Khoja, A. T ; Khosravi, M. H ; Khubchandani, J ; Kianipour, N ; Kim, D ; Kim, Y. J ; Kisa, A ; Kisa, S ; Kissimova Skarbek, K ; Komaki, H ; Koyanagi, A ; Krohn, K. J ; Bicer, B. K ; Kugbey, N ; Kumar, V ; Kuupiel, D ; La Vecchia, C ; Lad, D. P ; Lake, E. A ; Lakew, A. M ; Lal, D. K ; Lami, F. H ; Lan, Q ; Lasrado, S ; Lauriola, P ; Lazarus, J. V ; Leigh, J ; Leshargie, C. T ; Liao, Y ; Limenih, M. A ; Listl, S ; Lopez, A. D ; Lopukhov, P. D ; Lunevicius, R ; Madadin, M ; Magdeldin, S ; El Razek, H. M. A ; Majeed, A ; Maleki, A ; Malekzadeh, R ; Manafi, A ; Manafi, N ; Manamo, W. A ; Mansourian, M ; Mansournia, M .A ; Mantovani, L. G ; Maroufizadeh, S ; Martini, S. M. S ; Mashamba Thompson, T. P ; Massenburg, B. B ; Maswabi, M. T ; Mathur, M. R ; McAlinden, C ; McKee, M ; Meheretu, H. A. A ; Mehrotra, R ; Mehta, V ; Meier, T ; Melaku, Y. A ; Meles, G. G ; Meles, H. G ; Melese, A ; Melku, M ; Memiah, P. T. N ; Mendoza, W ; Menezes, R. G ; Merat, S ; Meretoja, T. J ; Mestrovic, T ; Miazgowski, B ; Miazgowski, T ; Mihretie, K. M. M ; Miller, T. R ; Mills, E. J ; Mir, S. M ; Mirzaei, H ; Mirzaei, H. R ; Mishra, R ; Moazen, B ; Mohammad, D. K ; Mohammad, K. A ; Mohammad, Y ; Darwesh, A. M ; Mohammadbeigi, A ; Mohammadi, H ; Mohammadi, M ; Mohammadian, M ; Mohammadian Hafshejani, A ; Mohammadoo Khorasani, M ; Mohammadpourhodki, R ; Mohammed, A. S ; Mohammed, J. A ; Mohammed, S ; Mohebi, F ; Mokdad, A. H ; Monasta, L ; Moodley, Y ; Moosazadeh, M ; Moossavi, M ; Moradi, G ; Moradi Joo, M ; Sharif University of Technology
    American Medical Association  2019
    Abstract
    Importance: Cancer and other noncommunicable diseases (NCDs) are now widely recognized as a threat to global development. The latest United Nations high-level meeting on NCDs reaffirmed this observation and also highlighted the slow progress in meeting the 2011 Political Declaration on the Prevention and Control of Noncommunicable Diseases and the third Sustainable Development Goal. Lack of situational analyses, priority setting, and budgeting have been identified as major obstacles in achieving these goals. All of these have in common that they require information on the local cancer epidemiology. The Global Burden of Disease (GBD) study is uniquely poised to provide these crucial data.... 

    Optimized doxycycline-loaded niosomal formulation for treatment of infection-associated prostate cancer: An in-vitro investigation

    , Article Journal of Drug Delivery Science and Technology ; Volume 57 , 2020 Akbarzadeh, I ; Tavakkoli Yaraki, M ; Bourbour, M ; Noorbazargan, H ; Lajevardi, A ; Sadat Shilsar, S. M ; Heidari, F ; Mousavian, S. M ; Sharif University of Technology
    Editions de Sante  2020
    Abstract
    Developing drug delivery systems with both antibacterial and anti-cancer effects is of importance in the treatment process of infection-associated cancers, especially prostate cancer. In this study, Span 60, Tween 60, and cholesterol were used to formulate doxycycline-loaded niosomes as a promising drug carrier system as either antibacterial or anticancer formulation. The formulation process was optimized by multi-objective response surface methodology (RSM), and then characterized. The developed niosomal formulation showed great storage stability for up to 2 weeks. In addition, they showed remarkable drug release in acidic solution (pH = 3) compared with physiological pH (7.4). The in-vitro... 

    Electrochemical prostate-specific antigen biosensors based on electroconductive nanomaterials and polymers

    , Article Clinica Chimica Acta ; Volume 516 , 2021 , Pages 111-135 ; 00098981 (ISSN) Dowlatshahi, S ; Abdekhodaie, M. J ; Sharif University of Technology
    Elsevier B.V  2021
    Abstract
    Prostate cancer (PCa), the second most malignant neoplasm in men, is also the fifth leading cause of cancer-related deaths in men globally. Unfortunately, this malignancy remains largely asymptomatic until late-stage emergence when treatment is limited due to the lack of effective metastatic PCa therapeutics. Due to these limitations, early PCa detection through prostate-specific antigen (PSA) screening has become increasingly important, resulting in a more than 50% decrease in mortality. Conventional assays for PSA detection, such as enzyme-linked immunosorbent assay (ELISA), are labor intensive, relatively expensive, operator-dependent and do not provide adequate sensitivity.... 

    Unraveling cancer metastatic cascade using microfluidics-based technologies

    , Article Biophysical Reviews ; Volume 14, Issue 2 , 2022 , Pages 517-543 ; 18672450 (ISSN) Hakim, M ; Kermanshah, L ; Abouali, H ; Hashemi, H. M ; Yari, A ; Khorasheh, F ; Alemzadeh, I ; Vossoughi, M ; Sharif University of Technology
    Springer Science and Business Media Deutschland GmbH  2022
    Abstract
    Cancer has long been a leading cause of death. The primary tumor, however, is not the main cause of death in more than 90% of cases. It is the complex process of metastasis that makes cancer deadly. The invasion metastasis cascade is the multi-step biological process of cancer cell dissemination to distant organ sites and adaptation to the new microenvironment site. Unraveling the metastasis process can provide great insight into cancer death prevention or even treatment. Microfluidics is a promising platform, that provides a wide range of applications in metastasis-related investigations. Cell culture microfluidic technologies for in vitro modeling of cancer tissues with fluid flow and the...