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    Preclinical evaluation of 188 Re-HYNIC-PSMA as a novel therapeutic agent

    , Article Journal of Radioanalytical and Nuclear Chemistry ; Volume 331, Issue 2 , 2022 , Pages 841-849 ; 02365731 (ISSN) Hadisi, M ; Vosoughi, N ; Yousefnia, H ; Bahrami-Samani, A ; Zolghadri, S ; Vosoughi, S ; Alirezapour, B ; Sharif University of Technology
    Springer Science and Business Media B.V  2022
    Abstract
    In this study, optimized preparation, quality control, cell assessments and biostribution of 188Re-HYNIC-PSMA in normal rats and tumor bearing mice are studied. Optimized conditions for radiolabeling were evaluated and radiochemical purity (> 99%) was investigated using ITLC and HPLC methods. 188Re-HYNIC-PSMA was stable both in PBS (4 °C) and in human serum (37 °C) even after 48 h. The results showed the complex was cleared from the blood very fast via urinary track. This new radiolabeled compound has a high potential to be considered as an agent for the treatment of patients with PSMA expressing tumors however more biological studies are still needed. © 2022, Akadémiai Kiadó, Budapest,... 

    Fuzzy support vector machine: An efficient rule-based classification technique for microarrays

    , Article BMC Bioinformatics ; Volume 14, Issue SUPPL13 , 2013 ; 14712105 (ISSN) Hajiloo, M ; Rabiee, H. R ; Anooshahpour, M ; Sharif University of Technology
    2013
    Abstract
    Background: The abundance of gene expression microarray data has led to the development of machine learning algorithms applicable for tackling disease diagnosis, disease prognosis, and treatment selection problems. However, these algorithms often produce classifiers with weaknesses in terms of accuracy, robustness, and interpretability. This paper introduces fuzzy support vector machine which is a learning algorithm based on combination of fuzzy classifiers and kernel machines for microarray classification.Results: Experimental results on public leukemia, prostate, and colon cancer datasets show that fuzzy support vector machine applied in combination with filter or wrapper feature selection... 

    Electrochemical prostate-specific antigen biosensors based on electroconductive nanomaterials and polymers

    , Article Clinica Chimica Acta ; Volume 516 , 2021 , Pages 111-135 ; 00098981 (ISSN) Dowlatshahi, S ; Abdekhodaie, M. J ; Sharif University of Technology
    Elsevier B.V  2021
    Abstract
    Prostate cancer (PCa), the second most malignant neoplasm in men, is also the fifth leading cause of cancer-related deaths in men globally. Unfortunately, this malignancy remains largely asymptomatic until late-stage emergence when treatment is limited due to the lack of effective metastatic PCa therapeutics. Due to these limitations, early PCa detection through prostate-specific antigen (PSA) screening has become increasingly important, resulting in a more than 50% decrease in mortality. Conventional assays for PSA detection, such as enzyme-linked immunosorbent assay (ELISA), are labor intensive, relatively expensive, operator-dependent and do not provide adequate sensitivity....