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Aptamer hybrid nanocomplexes as targeting components for antibiotic/gene delivery systems and diagnostics: a review
, Article International Journal of Nanomedicine ; Volume 15 , 2020 , Pages 4237-4256 ; Arab, Z ; Safarkhani, M ; Nasseri, B ; Rabiee, M ; Tahriri, M ; Webster, T. J ; Tayebi, L ; Rabiee, N ; Sharif University of Technology
Dove Medical Press Ltd
2020
Abstract
With the passage of time and more advanced societies, there is a greater emergence and incidence of disease and necessity for improved treatments. In this respect, nowadays, aptamers, with their better efficiency at diagnosing and treating diseases than antibodies, are at the center of attention. Here, in this review, we first investigate aptamer function in various fields (such as the detection and remedy of pathogens, modification of nanoparticles, antibiotic delivery and gene delivery). Then, we present aptamer-conjugated nanocomplexes as the main and efficient factor in gene delivery. Finally, we focus on the targeted co-delivery of genes and drugs by nanocomplexes, as a new exciting...