Loading...
Search for:
proton-beam-therapy
0.009 seconds
A comprehensive survey of proton beam therapy research and development in Iran
, Article Frontiers in Biomedical Technologies ; Volume 8, Issue 1 , 2021 , Pages 9-19 ; 23455829 (ISSN) ; Vosoughi, N ; Mahani, H ; Sharif University of Technology
Tehran University of Medical Sciences
2021
Abstract
Purpose: Proton Beam Therapy (PBT) is an emerging radiotherapy technique using beams of proton to treat cancer. As the first report addressing the topic, the principal aim is to highlight the present status of PBT research and development in Iran as a developing country. Materials and Methods: To do so, the demand for PBT in Iran and Iran National Ion Therapy Center (IRNitc) was investigated and introduced. Then, Scopus and PubMed were searched for studies that dealt with PBT research in Iran and subsequently 6 major subfields of interest were identified. Furthermore, international collaborations were extracted from the bibliographic data. To combine both research and development sides, a...
A fast and accurate gate model for small field scattering proton beam therapy
, Article 15th IEEE International Symposium on Medical Measurements and Applications, MeMeA 2020, 1 June 2020 through 3 June 2020 ; 2020 ; Vosoughi, N ; Mahani, H ; Sharif University of Technology
Institute of Electrical and Electronics Engineers Inc
2020
Abstract
Proton beam therapy (PBT) is a modern external beam radiation therapy characterized by superior dose distribution. Small field PBT refers to the treatment of tumor sizes less than 7 cm in diameter. In this study, a fast and accurate GATE model was developed and then validated for a small field scattering PBT delivery. To this aim, a fixed single scattering nozzle was modeled in the GATE platform. To accelerate the GATE simulations, a variance reduction technique (VRT) was also incorporated by ignoring the tracking of the secondary particles having a range below a predefined cutoff. In addition, the influence of collimator material on the model performance was evaluated. Beam uniformity,...
Development and validation of an optimal GATE model for double scattering proton beam delivery
, Article Journal of Instrumentation ; Volume 16, Issue 2 , 2021 ; 17480221 (ISSN) ; Vosoughi, N ; Mahani, H ; Sharif University of Technology
IOP Publishing Ltd
2021
Abstract
Proton therapy (PT) is an emerging external beam radiation therapy characterized by superior dose distribution compared to conventional modalities. In the present study, an optimal GATE model was developed and then validated for a double scattering proton nozzle based on the previously constructed model. To this aim, a double scattering treatment nozzle was modeled in the GATE platform. To accelerate the GATE simulations, a virtual range modulation wheel (vRMW) and a variance reduction technique (VRT) were implemented. Proton beam flatness, symmetry, and delivery efficiency, secondary neutron dose, and dosimetric performance were characterized through a set of GATE simulations. The findings...
Comparative assessment of passive scattering and active scanning proton therapy techniques using Monte Carlo simulations
, Article Journal of Instrumentation ; Volume 17, Issue 9 , 2022 ; 17480221 (ISSN) ; Hosseini, S. A ; Akhavanallaf, A ; Vosoughi, N ; Zaidi, H ; Sharif University of Technology
Institute of Physics
2022
Abstract
Background: in this study, two proton beam delivery designs, i.e. passive scattering proton therapy (PSPT) and pencil beam scanning (PBS), were quantitatively compared in terms of dosimetric indices. The GATE Monte Carlo (MC) particle transport code was used to simulate the proton beam system; and the developed simulation engines were benchmarked with respect to the experimental measurements. Method: A water phantom was used to simulate system energy parameters using a set of depth-dose data in the energy range of 120-235 MeV. To compare the performance of PSPT against PBS, multiple dosimetric parameters including Bragg peak width (BP W50), peak position, range, peak-To-entrance dose ratio,...
Modeling and optimization of respiratory-gated partial breast irradiation with proton beams - A Monte Carlo study
, Article Computers in Biology and Medicine ; Volume 147 , 2022 ; 00104825 (ISSN) ; Vosoughi, N ; Mahani, H ; Sharif University of Technology
Elsevier Ltd
2022
Abstract
The selection of a suitable duty factor (DF) remains a major challenge in respiratory-gated treatments. Therefore, this study aims at presenting a new methodology for fast optimizing the gating window width (duty factor (DF)) in respiratory-gated proton partial breast irradiation (PBI). To do so, GATE Monte Carlo simulations were performed for various target sizes and locations in supine and prone positions. Three different duty factors of 20, 25, and 33% were considered. Sparing factors (SF) for four organs-at-risk (OARs) were then assessed. The weighted-sum method was employed to search for an optimal DF. The results indicate that an SF higher than unity was obtained for all plans. The SF...