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pyrazine
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A facile and convenient synthesis of 3-alkylidene-oxindoles bearing tetrahydropyrazine scaffold under catalyst-free conditions
, Article Heteroatom Chemistry ; Volume 29, Issue 2 , March , 2018 ; 10427163 (ISSN) ; Moafi, A ; Sharif University of Technology
Wiley-Blackwell
2018
Abstract
A facile and efficient synthesis of 2-oxindole derivatives bearing tetrahydropyrazine scaffold has been developed. Using water as solvent without any additional acid or metal catalyst, easy work up and high yield of products are the main advantages of this protocol. © 2018 Wiley Periodicals, Inc
Synthesis and Characterization of some Heterocyclic Compounds Containing Nitrogen Using Oxindole Intermediate Skeleton
, Ph.D. Dissertation Sharif University of Technology ; Matloubi Moghadam, Firouz (Supervisor)
Abstract
In the first part of this thesis provided an efficient and easy method for the synthesis of 3-alkylidin-2-oxindoles containing tetrahydropyrazine structure in the absence of catalysts under green conditions. The oxindole unit represents an important structural motif found in natural products and biologically relevant compounds. On the other hand, pyrazines are important and well-known compounds found in nature and many medicinal compounds. According to the aforementioned, it seems that the oxindole compounds containing the pyrazine rings exhibit high biological activity.In the second chapter of this thesis, an efficient study to synthesize thiopyrano [2,3-b] quinoline containing indole...
Automated trace determination of earthy-musty odorous compounds in water samples by on-line purge-and-trap-gas chromatography-mass spectrometry
, Article Journal of Chromatography A ; Volume 1136, Issue 2 , 2006 , Pages 170-175 ; 00219673 (ISSN) ; Lacorte, S ; Bagheri, H ; Barceló, D ; Sharif University of Technology
2006
Abstract
An automated technique based on purge-and-trap coupled to gas chromatography with mass spectrometric detection has been developed and optimized for the trace determination of five of the most important water odorants; 2-isopropyl-3-methoxypyrazine, 2-isobutyl-3-methoxypyrazine, 2-methylisoborneol, 2,4,6-trichloroanisole and geosmin. The extraction method was absolutely solvent-free. Analytes were purged from 20 ml of water sample containing sodium chloride at room temperature by a flow of He and trapped on a Tenax sorbent. The desorption step was performed with helium and temperature programming and desorbed analytes were directly transferred to a gas chromatograph coupled to a mass...