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    In silico study of patient-specific magnetic drug targeting for a coronary LAD atherosclerotic plaque

    , Article International Journal of Pharmaceutics ; Volume 559 , 2019 , Pages 113-129 ; 03785173 (ISSN) Shamloo, A ; Amani, A ; Forouzandehmehr, M ; Ghoytasi, I ; Sharif University of Technology
    Elsevier B.V  2019
    Coronary artery disease is the first cause of death across the world. Targeted delivery of therapeutics through controlled release of micro- and nano-particles remains a very capable approach to develop new strategies in treating restenosis and atherosclerotic plaques. In this research, to produce the arterial geometry, an image-processing was done using CT-scan images of a LAD coronary artery. After implementing the finite element mesh, the Fluid-Structure Interaction (FSI) simulation based on physiological boundary conditions was performed. Next, a Lagrangian description of particles dynamics in a non-Newtonian blood flow considering momentum equation of motion for each particle and the...