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quadratic-calibration
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Development and Application of Multivariate Calibration Methods Combined with Gas Chromatography for Simultaneous Determination of Organophosphorous Pesticides in Complex Matrices
, M.Sc. Thesis Sharif University of Technology ; Parastar Shahri, Hadi (Supervisor)
Abstract
In this study, a new strategy based on chemometrics and extraction method of Quick, Easy, Cheap, Effective, Rugged and Safe (QuEChERS) combined with dispersive liquid–liquid micro-extraction (DLLME) in addition gas chromatography-flame ion detector (GC-FID) has been developed for the determination of ten pesticides in complex samples (such as tap water and milk).In this regard, experiments were designed, modeled and optimum condition was achieved by using central composite design (CCD), backward multiple linear regression (MLR) and Nelder-Mead simplex optimization. On this matter, 36 experiments for 5 extraction factors in 5 levels were generated. Also, multi-response optimization using...
Development of multi-response optimization and quadratic calibration curve for determination of ten pesticides in complex sample matrices using QuEChERS dispersive liquid–liquid microextraction followed by gas chromatography
, Article Journal of Separation Science ; Volume 42, Issue 23 , 2019 , Pages 3553-3562 ; 16159306 (ISSN) ; Parastar, H ; Sharif University of Technology
Wiley-VCH Verlag
2019
Abstract
In this study, QuEChERS combined with dispersive liquid-liquid microextraction is developed for extraction of ten pesticides in complex sample matrices of water and milk. In this regard, effective factors of proposed extraction technique combined with gas chromatography with flame ionization detector were designed, modeled, and optimized using central composite design, multiple linear regression, and Nelder–Mead simplex optimization. Later, univariate calibration model for ten pesticides was developed in concentration range of 0.5–100 ng/mL. Surprisingly, quadratic calibration behavior was observed for some of the pesticides. In this regard, Mandel's test was used for evaluating linearity...