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quinazolinones
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Synthesis of quinazolin-4(3H)-one derivatives using heteropolyacids as heterogeneous and recyclable catalysts
, Article Asian Journal of Chemistry ; Volume 23, Issue 4 , 2011 , Pages 1588-1590 ; 09707077 (ISSN) ; Hashemi, M. M ; Heravi, M. M ; Bamoharram, F. F ; Sharif University of Technology
Abstract
A highly efficient and simple procedure for the synthesis of quinazolin-4(3H)-ones from the condensation of 2-aminobenzamide with triethylorthoesters in presence of a catalytic amounts of heteropolyacids in various solvents is reported
Quantitative structure-activity relationship study of serotonin (5-HT7) receptor inhibitors using modified ant colony algorithm and adaptive neuro-fuzzy interference system (ANFIS)
, Article European Journal of Medicinal Chemistry ; Volume 44, Issue 4 , 2009 , Pages 1463-1470 ; 02235234 (ISSN) ; Asadollahi Baboli, M ; Sharif University of Technology
2009
Abstract
Quantitative structure-activity relationship (QSAR) approach was carried out for the prediction of inhibitory activity of some novel quinazolinone derivatives on serotonin (5-HT7) using modified ant colony (ACO) method and adaptive neuro-fuzzy interference system (ANFIS) combined with shuffling cross-validation technique. A modified ACO algorithm is utilized to select the most important variables in QSAR modeling and then these variables were used as inputs of ANFIS to predict 5-HT7 receptor binding activities of quinazolinone derivatives. The best descriptors describing the inhibition mechanism are Qmax, Se, Hy, PJI3 and DELS which are among electronic, constitutional, geometric and...