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    Retina-choroid-sclera permeability for ophthalmic drugs in the vitreous to blood direction: quantitative assessment

    , Article Pharmaceutical research ; Volume 30, Issue 1 , January , 2013 , Pages 41-59 ; 1573904X (ISSN) Haghjou, N ; Abdekhodaie, M. J ; Cheng, Y. L ; Sharif University of Technology
    To determine the outward permeability of retina-choroid-sclera (RCS) layer for different ophthalmic drugs and to develop correlations between drug physicochemical properties and RCS permeability. A finite volume model was developed to simulate pharmacokinetics in the eye following drug administration by intravitreal injection. The RCS permeability was determined for 32 compounds by best fitting the drug concentration-time profile obtained by simulation with previously reported experimental data. Multiple linear regression was then used to develop correlations between best fit RCS permeability and drugs physicochemical properties. The RCS drug permeabilities had values that ranged over 3 ×... 

    Early detection of immunization: A study based on an animal model using 1H nuclear magnetic resonance spectroscopy

    , Article Pakistan Journal of Biological Sciences ; Volume 14, Issue 3 , 2011 , Pages 195-203 ; 10288880 (ISSN) Zamani, Z ; Arjmand, M ; Tafazzoli, M ; Ghohzadeh, A ; Pourfallah, F ; Sadeghi, S ; Mirzazadeh, R ; Mirkham, F ; Tahen, S ; Iravam, A ; Bayat, P ; Vahabi, F ; Sharif University of Technology
    Vaccines require a period of at least three months for clinical trials, hence a method that can identify elicitation of immune response a few days after the first dose is a necessity. Evolutionary variable selections are modeling approaches for proper manipulation of available data which were used to set up an animal model for classification of time dependent 'HNMR metabolomic profiles and pattern recognition of fluctuations of metabolites in two groups of male rabbits. One group of rabbits was immunized with human red blood cells and the other used as control. Blood was obtained every 48 h from each rabbit for a period of six weeks and the serum monitored for antibodies and metabolites by... 

    Disc size markedly influences concentration profiles of intravenously administered solutes in the intervertebral disc: A computational study on glucosamine as a model solute

    , Article European Spine Journal ; Vol. 23, issue. 4 , April , 2014 , p. 715-723 Motaghinasab, S ; Shirazi-Adl, A ; Parnianpour, M ; Urban, J. P. G ; Sharif University of Technology
    Purpose: Tests on animals of different species with large differences in intervertebral disc size are commonly used to investigate the therapeutic efficacy of intravenously injected solutes in the disc. We hypothesize that disc size markedly affects outcome. Methods: Here, using a small non-metabolized molecule, glucosamine (GL) as a model solute, we calculate the influence of disc size on transport of GL into rat, rabbit, dog and human discs for 10 h post intravenous-injection. We used transient finite element models and considered an identical GL supply for all animals. Results: Huge effects of disc size on GL concentration profiles were found. Post-injection GL concentration in the rat... 

    Magnetic resonance imaging tracking of stem cells in vivo using iron oxide nanoparticles as a tool for the advancement of clinical regenerative medicine

    , Article Chemical Reviews ; Volume 111, Issue 2 , November , 2011 , Pages 253-280 ; 00092665 (ISSN) Mahmoudi, M ; Hosseinkhani, H ; Hosseinkhani, M ; Boutry, S ; Simchi, A ; Shane Journeay, W ; Subramani, K ; Laurent, S ; Sharif University of Technology
    Fetal stem cells, which can be isolated from the organs of fetuses, differentiate along multiple lineages. Their advantages over their adult counterparts include better intrinsic homing and engraftment and lower immunogenicity, and they are less ethically contentious. It is noteworthy that Mesenchymal Stem Cells (MSC) can be activated and mobilized at the site of damaged tissue. Since vascular delivery suffers from a pulmonary first pass effect, direct or systemic injection of MSCs into the damaged tissue is preferred, particularly in the case of versatile tissue ischemia. Ultrasound applies acoustic energy with a frequency above human hearing (20 kHz). Ultrasound imaging or sonography... 

    Fabrication of a novel 3D scaffold for cartilage tissue repair: In-vitro and in-vivo study

    , Article Materials Science and Engineering C ; Volume 128 , 2021 ; 09284931 (ISSN) Haghighi, P ; Shamloo, A ; Sharif University of Technology
    Elsevier Ltd  2021
    Self-repairing is not an advanced ability of articular cartilage. Tissue engineering has provided a novel way for reconstructing cartilage using natural polymers because of their biocompatibility and bio-functionality. The purpose of cartilage tissue engineering is to design a scaffold with proper pore structure and similar biological and mechanical properties to the native tissue. In this study, porous scaffolds prepared from gelatin, chitosan and silk fibroin were blended with varying ratios. Between the blends of chitosan (C), gelatin (G) and silk fibroin (S), the scaffold with the weight per volume ratio of 2:2:3 (w/v) showed the most favorable and higher certain properties than the... 

    Synthesis and characterization of gold nanotube/nanowire-polyurethane composite based on castor oil and polyethylene glycol

    , Article Materials Science and Engineering C ; Vol. 42 , 2014 , pp. 341-349 ; ISSN: 09284931 Ganji, Y ; Kasra,M ; Salahshour Kordestani, S ; Bagheri Hariri, M ; Sharif University of Technology
    Gold nanotubes/nanowires (GNT/NW) were synthesized by using the template-assisted electrodeposition technique and mixed with castor oil-polyethylene glycol based polyurethane (PU) to fabricate porous composite scaffolds for biomedical application. 100 and 50 ppm of GNT/NW were used to synthesize composites. The composite scaffolds were characterized by Fourier transform infrared spectroscopy, dynamic mechanical thermal analysis, differential scanning calorimetry, and scanning electron microscopy. Cell attachment on polyurethane-GNT/NW composites was investigated using fat-derived mesenchymal stem cells. Addition of 50 or 100 ppm GNT/NW had significant effects on thermal, mechanical, and cell... 

    Assessing the role of Ca2+ in skeletal muscle fatigue using a multi-scale continuum model

    , Article Journal of Theoretical Biology ; Volume 461 , 2019 , Pages 76-83 ; 00225193 (ISSN) Karami, M ; Calvo, B ; Zohoor, H ; Firoozbakhsh, K ; Grasa, J ; Sharif University of Technology
    Academic Press  2019
    The Calcium ion Ca2+ plays a critical role as an initiator and preserving agent of the cross-bridge cycle in the force generation of skeletal muscle. A new multi-scale chemo-mechanical model is presented in order to analyze the role of Ca2+ in muscle fatigue and to predict fatigue behavior. To this end, a cross-bridge kinematic model was incorporated in a continuum based mechanical model, considering a thermodynamic compatible framework. The contractile velocity and the generated active force were directly related to the force-bearing states that were considered for the cross-bridge cycle. In order to determine the values of the model parameters, the output results of an isometric simulation...