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radiosensitizing-agent
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ZnFe2O4 nanoparticles as radiosensitizers in radiotherapy of human prostate cancer cells
, Article Materials Science and Engineering C ; Volume 46 , January , 2015 , Pages 394-399 ; 09284931 (ISSN) ; Akhavan, O ; Khoei, S ; Shokri, A. A ; Hajikarimi, Z ; Khansari, N ; Sharif University of Technology
Elsevier Ltd
2015
Abstract
Nanoparticles of high-Z elements exhibit stronger photoelectric effects than soft tissues under gamma irradiation. Hence, they can be used as effective radiosensitizers for increasing the efficiency of current radiotherapy. In this work, superparamagnetic zinc ferrite spinel (ZnFe2O4) nanoparticles were synthesized by a hydrothermal reaction method and used as radiosensitizers in cancer therapy. The magnetic nanoparticles showed fast separation from solutions (e.g., ~ 1 min for 2 mg mL- 1 of the nanoparticles in ethanol) by applying an external magnetic field (~ 1 T). The ZnFe2O4 nanoparticles were applied in an in vitro radiotherapy of lymph node carcinoma of prostate cells (as high...