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raloxifene
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Application of glassy carbon electrode modified with a carbon nanoparticle/melamine thin film for voltammetric determination of raloxifene
, Article Journal of Electroanalytical Chemistry ; Volume 780 , 2016 , Pages 126-133 ; 15726657 (ISSN) ; Ghalkhani, M ; Balotf, H ; Salimian, R ; Sharif University of Technology
Elsevier B.V
2016
Abstract
As a selective estrogen receptor modulator, raloxifene (RXF) prevent of osteoporosis in postmenopausal women by estrogenic actions on bone and decreases the risk of invasive breast cancer by anti-estrogenic actions on the breast and uterus tissue. However, RXF may increase the risk of blood clots, including deep vein thrombosis and pulmonary embolism. For the first time glassy carbon electrode modified with a thin film of melamine/carbon nanoparticles (CNPs/Mela) was constructed and used for the sensitive voltammetric determination of RXF. In comparison with unmodified electrode, the presence of the CNPs/Mela film resulted in a remarkable increase in the peak currents and sharpness of the...
Preparation and characterization of raloxifene nanoparticles using Rapid Expansion of Supercritical Solution (RESS)
, Article Journal of Supercritical Fluids ; Volume 63 , 2012 , Pages 169-179 ; 08968446 (ISSN) ; Karimi Sabet, J ; Fattahi, A ; Golzary, A ; Rafiee Tehrani, M ; Dorkoosh, F. A ; Sharif University of Technology
2012
Abstract
One of the key factors in drug's efficacy is the value of their bioavailability that increases by the reduction of particle size through improvement of dissolution rate. In this study, raloxifene particle size was reduced by Rapid Expansion of Supercritical Solution (RESS). The effect of extraction temperature (40-80 °C), extraction pressure (10-18 MPa) and spray distance (5-10 cm) were investigated on size and particle size distribution of the nanoparticles. Particles were characterized using X-ray diffraction (XRD), Fourier Transform Infrared Analysis (FTIR), Differential Scanning Calorimetry (DSC), Scanning Electron Microscopy (SEM) and Dynamic Light Scattering (DLS). The average size of...