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    Meaurement of Flow Mediated Dilation Using Photoplethysmography

    , M.Sc. Thesis Sharif University of Technology Goldoozian, Layli Sadat (Author) ; Zahedi, Edmond (Supervisor)
    Endothelial cells cover the inner surface of blood vessels. In response to different physical (such as reactive hyperemia-RH) and pharmacological stimuli, they maintain homeostasis by changing the vascular diameter (by releasing chemical agents like nitric oxide). The endothelium inability to respond to metabolic need (endothelial dysfunction) is an early marker of cardiovascular diseases such as atherosclerosis. Flow mediated dilation (FMD) measurement using ultrasound imaging (FMD-US) has been established as a standard method for assessing the endothelial function. Recently, a less skilled-operator demanding method has been proposed based on the photoplethysmographic (PPG) signal changes... 

    Modeling the Endothelial Function in the Brachial Artery Using Photoplethysmography

    , M.Sc. Thesis Sharif University of Technology Mashayekhi, Ghoncheh (Author) ; Zahedi, Edmond (Supervisor) ; Jahed, Mehran (Supervisor)
    Flow Mediated Dilation (FMD) is a non-invasive method for endothelial function assessment providing an index extracted from ultrasonic B-mode images. Although utilized in the research community, the difficulty of its application and high cost of ultrasonic device prevent it from being widely used in clinical settings. In this study we show that substituting the ultrasonic device with more easily handled and low cost photoplethysmography and electrocardiography is possible. We introduce new indices based on the photoplethysmogram (PPG) and electrocardiogram (ECG) and show that they are correlated with the ultrasound-based FMD index. To this end, conventional ultrasound FMD test was carried... 

    Modeling of photoplethysmography signal for quantitative analysis of endothelial cells during reactive hyperemia

    , Article 2012 19th Iranian Conference of Biomedical Engineering, ICBME 2012 ; 2012 , Pages 174-178 ; 9781467331302 (ISBN) Shiri, F ; Firoozabadi, B ; Saidi, M. S ; Sharif University of Technology
    In this study, at first the cardiovascular system is modeled based on the 1D method and then the simulation of the reactive hyperemia experiment has been applied on the model. In this simulation, by applying a cuff at the brachial artery, the flow downstream of the cuff is occluded. Then with releasing the cuff immediately, a large amount of shear stress, about 4 times the basal amount, is applied downstream of the cuff and consequently to the endothelial cells in a very short moment. Considering a reported experimental transfer function between shear stress and vasodilation, the increase of the artery diameter due to the sudden increase of the shear stress is obtained. Finally, the... 

    Electrical analog model of arterial compliance during reactive hyperemia

    , Article 2011 1st Middle East Conference on Biomedical Engineering, MECBME 2011, 21 February 2011 through 24 February 2011, Sharjah ; 2011 , Pages 49-53 ; 9781424470006 (ISBN) Goldoozian, L. S ; Zahedi, E ; Sharif University of Technology
    Flow mediated dilation (FMD) measurement using ultrasound imaging (FMD-US) has been established as a standard method for assessing the endothelial function. Recently, a less skilled-operator demanding method has been proposed based on the photoplethysmogram (PPG) changes during reactive hyperemia. It was shown that the amplitude of the PPG pulse (FMD-PPG) changed in a quite similar manner to that of the artery diameter in the method of the FMD-US i.e. increases following releasing the cuff and then gradually returns to baseline. In this study PPG changes following reactive hyperaemia were modelled using time-varying passive electrical elements (R, L and C). The output of the electric analog... 

    Definition and comparison of a new vascular index between young healthy and aged subjects

    , Article IECBES 2014, Conference Proceedings - 2014 IEEE Conference on Biomedical Engineering and Sciences: "Miri, Where Engineering in Medicine and Biology and Humanity Meet", 8 December 2014 through 10 December 2014 ; 2015 , Pages 911-915 ; 9781479940844 (ISBN) Jaafar, R ; Zahedi, E ; Mohd Ali, M. A ; Sharif University of Technology
    Institute of Electrical and Electronics Engineers Inc  2015
    In an effort to identify a useful noninvasive screening tool for cardiovascular diseases (CVD) screening, photoplethysmograph (PPG) signals were acquired and analyzed. These PPG signals were recorded during reactive hyperemia experiments consisting of a 4-minute blood flow blockage of the right arm (RA) brachial artery (BA) using a blood pressure cuff inflator. This procedure is usually done for the assessment of endothelial dysfunction which is a risk factor for developing CVD. In this study, signals of the infrared (IR) and red (R) LED's of the PPG sensor were analyzed. These signals were preprocessed, normalized and slow varying component of the signal (DC values) and the pulsatile... 

    Effect of dyslipidemia on a simple morphological feature extracted from photoplethysmography flow mediated dilation

    , Article International Conference in Electronic Engineering and Computing Technology, London, 1 July 2009 through 3 July 2009 ; Volume 60 LNEE , 2010 , Pages 551-561 ; 18761100 (ISSN) ; 9789048187751 (ISBN) Zaheditochai, M ; Zahedi, E ; Mohd Ali, M. A ; Sharif University of Technology
    Dyslipidemia is considered to be one of the main heart risk factors, affecting the endothelial vascular function, which can be non-invasively investigated by ultrasound flow-mediated dilation (US-FMD). However, US-FMD comes at a high-cost and is operator-dependent. In this paper, the effect of dyslipidemia on the photoplethysmogram (PPG) signal recorded from collateral index fingers is investigated following a previous study where it was shown that results similar to that of US-FMD can be replicated by the PPG. Two groups, consisting of 30 healthy subjects free from any risk factors and 30 subjects who have only dyslipidemia as risk factor were respectively considered. The percent change in...