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    Individual differences in nucleus accumbens dopamine receptors predict development of addiction-like behavior: A computational approach

    , Article Neural Computation ; Volume 22, Issue 9 , 2010 , Pages 2334-2368 ; 08997667 (ISSN) Piray, P ; Keramati, M. M ; Dezfouli, A ; Lucas, C ; Mokri, A ; Sharif University of Technology
    2010
    Abstract
    Clinical and experimental observations show individual differences in the development of addiction. Increasing evidence supports the hypothesis that dopamine receptor availability in the nucleus accumbens (NAc) predisposes drug reinforcement. Here, modeling striatal-midbrain dopaminergic circuit, we propose a reinforcement learning model for addiction based on the actor-critic model of striatum. Modeling dopamine receptors in the NAc as modulators of learning rate for appetitive-but not aversive-stimuli in the critic-but not the actor-we define vulnerability to addiction as a relatively lower learning rate for the appetitive stimuli, compared to aversive stimuli, in the critic. We... 

    Dopamine receptors gene expression pattern and locomotor improvement differ between female and male zebrafish during spinal cord auto repair

    , Article Zebrafish ; Volume 19, Issue 4 , 2022 , Pages 137-147 ; 15458547 (ISSN) Hosseini, P ; Mirsadeghi, S ; Rahmani, S ; Izadi, A ; Rezaei, M ; Ghodsi, Z ; Rahimi Movaghar, V ; Kiani, S ; Sharif University of Technology
    Mary Ann Liebert Inc  2022
    Abstract
    The dopaminergic system, a spinal cord (SC) motor circuit regulator, is administrated by sexual hormones and evolutionary conserved in all vertebrates. Accordingly, we hypothesized that the dopamine receptor (DAR) expression pattern may be dissimilar in female and male zebrafish SC auto repair. We implemented an uncomplicated method to induce spinal cord injury (SCI) on fully reproductive adult zebrafish, in both genders. SCI was induced using a 28-gauge needle at 9th-10th vertebra without skin incision. Thereupon, lesioned SC was harvested for DAR gene expression analysis; zebrafish were tracked routinely for any improvement in swim distance, speed, and their roaming... 

    Detection of dopamine receptors using nanoscale dendrimer for potential application in targeted delivery and whole-body imaging: synthesis and in vivo organ distribution

    , Article ACS Applied Bio Materials ; Volume 5, Issue 4 , 2022 , Pages 1744-1755 ; 25766422 (ISSN) Ramezani Farani, M ; Aminzadeh Jahromi, N ; Ali, V ; Ebrahimpour, A ; Salehian, E ; Shafiee Ardestani, M ; Seyedhamzeh, M ; Ahmadi, S ; Sharifi, E ; Ashrafizadeh, M ; Rabiee, N ; Makvandi, P ; Sharif University of Technology
    American Chemical Society  2022
    Abstract
    Dopamine is one of the most important neurotransmitters released by neurons in the central nervous system, and a variety of neurological illnesses and mental disorders are associated with impairments in the secretion and functionality of dopamine. Dopamine, depending on the type of receptors, can act as a stimulant or an inhibitor. In this study, dendrimer-conjugated dopamine was utilized as a chelating agent for Technetium-99m to investigate the organ distribution of this compound in vivo using the single-photon emission computed tomography (SPECT) technique. For this purpose, dendrimers were synthesized using polyethylene glycol diacid and citric acid precursors, and dopamine was... 

    Mining the potential of label-free biosensors for in vitro antipsychotic drug screening

    , Article Biosensors ; Volume 8, Issue 1 , 2018 ; 20796374 (ISSN) Kilic, T ; Soler, M ; Fahimi Kashani, N ; Altug, H ; Carrara, S ; Sharif University of Technology
    MDPI AG  2018
    Abstract
    The pharmaceutical industry is facing enormous challenges due to high drug attribution rates. For the past decades, novel methods have been developed for safety and efficacy testing, as well as for improving early development stages. In vitro screening methods for drug-receptor binding are considered to be good alternatives for decreasing costs in the identification of drug candidates. However, these methods require lengthy and troublesome labeling steps. Biosensors hold great promise due to the fact that label-free detection schemes can be designed in an easy and low-cost manner. In this paper, for the first time in the literature, we aimed to compare the potential of label-free optical and...