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regioselective-synthesis
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Synthesis, characterization and application of magnetic room temperature dicationic ionic liquid as an efficient catalyst for the preparation of 1,2-azidoalcohols
, Article Journal of Molecular Liquids ; Volume 183 , 2013 , Pages 14-19 ; 01677322 (ISSN) ; Kiasat, A. R ; Hashemi, M. M ; Sharif University of Technology
2013
Abstract
An environmentally benign, aqueous synthesis of 1,2-azidoalcohols via regioselective ring opening of their epoxides using magnetic imidazolium based dicationic room temperature ionic liquid, [pbmim](FeCl4)2, as an efficient magnetic phase transfer catalyst in water has been described. The present approach offers the advantages of clean reaction, simple methodology, short reaction time, high yield, easy purification and reusable catalyst
Regio- and diastereoselective synthesis of novel polycyclic pyrrolo[2,1- a]isoquinolines bearing indeno[1,2- b]quinoxaline moieties by a three-component [3+2]-cycloaddition reaction
, Article Synlett ; Volume 31, Issue 3 , 2020 , Pages 267-271 ; Moafi, A ; Jafari, B ; Vilinger, A ; Langer, P ; Sharif University of Technology
Georg Thieme Verlag
2020
Abstract
A regio- and diastereoselective synthesis of 2,3-dihydro-10b′ H -spiro[indeno[1,2- b ]quinoxaline-11,1′-pyrrolo[2,1- a ]isoquinoline]-2′,3′-diylbis(phenylmethanone) derivatives containing four contiguous chiral stereocenters was achieved through 1,3-dipolar cycloaddition of isoquinolinium N -ylides in a one-pot three-component reaction. The desired products were obtained in short reaction times and in moderate to high yields (up to 92%) under relatively mild reaction conditions. The structure and relative stereochemistry of the desired product was confirmed by X-ray diffraction analysis. © 2020 Georg Thieme Verlag. All rights reserved