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    Fluid–structure interaction simulation of a cerebral aneurysm: effects of endovascular coiling treatment and aneurysm wall thickening

    , Article Journal of the Mechanical Behavior of Biomedical Materials ; Volume 74 , 2017 , Pages 72-83 ; 17516161 (ISSN) Shamloo, A ; Nejad, M. A ; Saeedi, M ; Sharif University of Technology
    In the present study, we investigate the effect of the hemodynamic factors of the blood flow on the cerebral aneurysms. To this end, a hypothetical geometry of the aneurysm in the circle of Willis, located in the bifurcation point of the anterior cerebral artery (ACA) and anterior communicating artery (ACoA) is modeled in a three-dimensional manner. Three cases are chosen in the current study: an untreated thin wall (first case), untreated thick wall (second case), and a treated aneurysm (third case). The effect of increasing the aneurysm wall thickness on the deformation and stress distribution of the walls are studied. The obtained results showed that in the second case, a reduction in the... 

    Atheroprone sites of coronary artery bifurcation: Effect of heart motion on hemodynamics-dependent monocytes deposition

    , Article Computers in Biology and Medicine ; Volume 133 , 2021 ; 00104825 (ISSN) Biglarian, M ; Firoozabadi, B ; Saidi, M. S ; Sharif University of Technology
    Elsevier Ltd  2021
    Atherosclerosis as a common cardiovascular disease is a result of both adverse hemodynamics conditions and monocyte deposition within coronary arteries. It is known that the adhesion of monocytes on the arterial wall and their interaction with the vascular surface are one of the main parameters in the initiation and progression of atherosclerosis. In this work, hemodynamic parameters and monocyte deposition have been investigated in a 3D computational model of the Left Anterior Descending coronary artery (LAD) and its first diagonal branch (D1) under the heart motion. A one-way Lagrangian approach is performed to trace the monocyte particles under different blood flow regimes and heart motion...