Search for: release-kinetics
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    Diffusional release of a solute from a spherical reservoir into a finite external volume

    , Article Journal of Pharmaceutical Sciences ; Volume 91, Issue 8 , 2002 , Pages 1803-1809 ; 00223549 (ISSN) Abdekhodaie, M. J ; Sharif University of Technology
    John Wiley and Sons Inc  2002
    An exact solution has been obtained for the release kinetics of a solute from a spherical reservoir with the burst effect initial condition into a finite external volume. The exact solution is derived based on the time Laplace transform method. The results presented here indicate that as the external fluid volume increases, the cumulative release at any time and the releasable amount of the solute at infinite time increase. In addition, for a given external volume, as the polymeric coat thickness increases the fractional release at any time decreases, Experimentally, cumulative release profiles of theophylline microspheres coated with ethylene vinyl acetate copolymer into different external... 

    The Development of Anti-Microbial PLA Nanocomposites

    , M.Sc. Thesis Sharif University of Technology Haj Seyyd Ahmadi, Reyhaneh (Author) ; Frounchi, Masoud (Supervisor)
    One of the great challenges of food industry is the lack of packing materials which can disperse active compositions properly for variety of applications; therefore an antioxidant/antibacterial release system of poly lactic acid in a specific time is a necessity for being used in food packing industry. Most of the researches have been done in the field of drug release system, yet numbers of researches done in the field of food industry are rare. Rate of antibacterial/antioxidant release from polymeric film is relatively fast also calculated based on Fick’s second law of diffusion; therefore primary poly lactic acid is modified by adding ameliorative agents such as poly ethylene glycol and... 

    Effect of formulation factors on the bioactivity of glucose oxidase encapsulated chitosan-alginate microspheres: In vitro investigation and mathematical model prediction

    , Article Chemical Engineering Science ; Volume 125 , March , 2015 , Pages 4-12 ; 00092509 (ISSN) Abdekhodaie, M. J ; Cheng, J ; Wu, X. Y ; Sharif University of Technology
    Elsevier Ltd  2015
    Higher reactive oxygen species (ROS) levels in cancer cells than normal cells have long been recognized, which makes cancer cells more susceptible to excess ROS. Thus oxidation (also called pro-oxidant) therapy has been explored as new cancer therapy regimens. To produce additional ROS, e.g. H2O2 in situ within tumor, we encapsulated glucose oxidase in chitosan-coated alginate-calcium microspheres (GOX-MS) for locoregional treatment and demonstrated its efficacy against cancer cells in vitro and in vivo. Owing to the complex biological functions of ROS, the production rate and amount of H2O2 are critical to achieve therapeutic benefits without causing normal tissue toxicity. This work was... 

    PLA microspheres-embedded pva hydrogels prepared by gamma-irradiation and freeze-thaw methods as drug release carriers

    , Article International Journal of Polymeric Materials and Polymeric Biomaterials ; Volume 62, Issue 1 , 2013 , Pages 28-33 ; 00914037 (ISSN) Behnoodfar, D ; Dadbin, S ; Frounchi, M ; Sharif University of Technology
    A drug delivery system based on poly (vinyl alcohol) (PVA) hydrogels containing ibuprofen-loaded poly (lactic acid) (PLA) microspheres was developed to improve the release kinetics of this model drug. Gamma-irradiation and freeze-thawing were applied to prepare poly (vinyl alcohol) hydrogels. Properties and morphology of these composite hydrogels were investigated using FTIR, DSC, and SEM. In vitro release indicated that entrapment of the microspheres into the PVA hydrogels causes a reduction in both the release rate and the initial burst effect. PLA microspheres entrapped into the PVA hydrogels showed more suitable controlled release kinetics for drug delivery  

    Construction of 3D fibrous PCL scaffolds by coaxial electrospinning for protein delivery

    , Article Materials Science and Engineering C ; Volume 113 , 2020 Rafiei, M ; Jooybar, E ; Abdekhodaie, M. J ; Alvi, M ; Sharif University of Technology
    Elsevier Ltd  2020
    In this study, a three-dimensional tablet-like porous scaffold, comprising core-shell fibers to host proteins inside the core, was developed. The fabrication method involved the novel combination of coaxial and wet electrospinning in a single setting. Poly (ε-caprolactone) was chosen as the based polymer and bovine serum albumin was used as a model protein. These 3D tablet-like scaffolds exhibited adequate porosity and suitable pore size for cell culture and cell infiltration, in addition to appropriate mechanical properties for cartilage tissue engineering. The effects of different parameters on the behavior of the system have been studied and the 3D scaffold based on the core-shell fiber... 

    Drug release from ion-exchange microspheres: Mathematical modeling and experimental verification

    , Article Biomaterials ; Volume 29, Issue 11 , 2008 , Pages 1654-1663 ; 01429612 (ISSN) Abdekhodaie, M. J ; Wu, X. Y ; Sharif University of Technology
    This paper presents for the first time a mathematical model for a mechanism of controlled drug release involving both ion exchange and transient counter diffusion of a drug and counterions. Numerical analysis was conducted to study the effect of different factors on drug release kinetics including environmental condition, material properties, and design parameters. The concentration profiles of counterions and drug species, the moving front of ion exchange, and three distinct regions inside a microsphere, namely unextracted region, ion-exchange region and drug diffusion region, were revealed by model prediction. The numerical results indicated that the rate of drug release increased with an... 

    Recent progress in inorganic and composite coatings with bactericidal capability for orthopaedic applications

    , Article Nanomedicine: Nanotechnology, Biology, and Medicine ; Volume 7, Issue 1 , Feb , 2011 , Pages 22-39 ; 15499634 (ISSN) Simchi, A ; Tamjid, E ; Pishbin, F ; Boccaccini, A. R ; Sharif University of Technology
    This review covers the most recent developments of inorganic and organic-inorganic composite coatings for orthopedic implants, providing the interface with living tissue and with potential for drug delivery to combat infections. Conventional systemic delivery of drugs is an inefficient procedure that may cause toxicity and may require a patient's hospitalization for monitoring. Local delivery of antibiotics and other bioactive molecules maximizes their effect where they are required, reduces potential systemic toxicity and increases timeliness and cost efficiency. In addition, local delivery has broad applications in combating infection-related diseases. Polymeric coatings may present some...