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    Decision Matrix for a Safe Aerial Launch Release Mechanism

    , M.Sc. Thesis Sharif University of Technology Salmani, Hamed (Author) ; Malaek, Mohammad Bagher (Supervisor)
    The case of rapid small satellite aerial launch by mother airplane has various applications; such as space experiment, weather monitoring, and getting information from the earth monitoring during natural disasters. In this method, the satellite and the launch vehicle will be carried up by mother airplane to the definite height; then, the launch vehicle will be released and flied - to the insert of satellite into the desired orbit. Aerial launch system success depends on a set of complex elements and their interactions. In the present study, first of all, the element interactions will be investigated by system engineering approach based on operational scenarios; then, a new approach for... 

    Experimental and Numerical Study of a Shape Memory Alloy Wire Rope Behavior in Release Mechanism

    , M.Sc. Thesis Sharif University of Technology Malekian, Ali (Author) ; Naghdabadi, Reza (Supervisor) ; Arghavani Hadi, Jamal (Supervisor)
    Smart materials are able to change their physical properties under various environmental conditions. Shape memory alloys (SMA) are relatively new smart materials that can respond to environmental stimuli e.g., heat, electricity, etc. Unique behaviors of SMAs, called shape memory effect and superelasticity, have motivated many applications in various fields of study (aerospace, medical, civil engineering, etc.). Although the behavior of SMAs is complicated, modeling and utilizing these materials have been receiving much attention in the past 20 years. Since a cable tolerate more tension than a wire or rod, the shape memory alloy cables could have a broad range of potential applications.... 

    Loading of Drug and Nanostructured Coating on Dental Implant

    , M.Sc. Thesis Sharif University of Technology Abbaspour Ghomi, Somayya (Author) ; Sadrnezhaad, Khatiboleslam (Supervisor)
    The aim of this project is to load analgesic drug; Paracetamol on dental implant. The implant is titanium alloy (Ti-6Al-4V). There are two kinds of samples of anodized and HA coated onto anodized. They are in the shape of the sheets in this study. The electrodeposition and anodization carried out in order to treat the two samples. Nanotubes were formed during anodic oxidation of the samples in the 1M Ammonium sulfate (NH₄)₂SO4 and 5wt% Ammonium fluoride NH4F electrolyte. They are expected to play role of carrier for the model drug; paracetamol. The results showed that HA anodized Ti-6-4 has the ability to hold higher amounts of drug and also can keep the drug for a longer time than the... 

    Corrosion Protection of Aluminium by Smart Coatings Containing Layered Double Hydroxide (LDH) Nanocontainers

    , Ph.D. Dissertation Sharif University of Technology Imanieh, Iman (Author) ; Afshar, Abdollah (Supervisor)
    Smart coatings which prevent corrosion by several mechanisms recently have been carefully planned. One of these mechanisms is the use of ion exchangers like Layered Double Hydroxide (LDH) in the coating network. In this study, the LDH containing a kind of green inhibitor (sodium molybdate) was synthesized and utilized in a Poly-Vinyl Alcohol (PVA) base coating applied on the aluminium (5054 series) surface. After evaluating the LDH performance, the inhibitor release from the LDH crystals was examined by changing significant parameters like MII/MIII (the molar ratio of divalent ions into trivalent ions), pH, aging time and temperature. Considering the LDH morphology or the thickness of the... 

    Nanocaged platforms: Modification, drug delivery and nanotoxicity. Opening synthetic cages to release the tiger

    , Article Nanoscale ; Volume 9, Issue 4 , 2017 , Pages 1356-1392 ; 20403364 (ISSN) Sahandi Zangabad, P ; Karimi, M ; Mehdizadeh, F ; Malekzad, H ; Ghasemi, A ; Bahrami, S ; Zare, H ; Moghoofei, M ; Hekmatmanesh, A ; Hamblin, M. R ; Sharif University of Technology
    Royal Society of Chemistry  2017
    Nanocages (NCs) have emerged as a new class of drug-carriers, with a wide range of possibilities in multi-modality medical treatments and theranostics. Nanocages can overcome such limitations as high toxicity caused by anti-cancer chemotherapy or by the nanocarrier itself, due to their unique characteristics. These properties consist of: (1) a high loading-capacity (spacious interior); (2) a porous structure (analogous to openings between the bars of the cage); (3) enabling smart release (a key to unlock the cage); and (4) a low likelihood of unfavorable immune responses (the outside of the cage is safe). In this review, we cover different classes of NC structures such as virus-like... 

    Design and Fabrication of Polymeric Drug Delivery System and Investigation of its Release Behavior

    , M.Sc. Thesis Sharif University of Technology Mahdavi, Reza (Author) ; Vosoughi, Manoochehr (Supervisor) ; Alizadeh, Ali (Supervisor)
    In the present study we examined the fabrication of electrospun polymer drug delivery system for the production of polymeric film containing Rizatriptan drug. Fabricated films were underwent X-ray diffraction and DSC tests to ensure that the drug is not in crystalline and amorphous form. And the results revealed the fact that the drug is fully dispersed in the polymer. pH changes in the aqueous phase is too low so that it enable the polymeric film to be suitable for use in oral administration. In-vitro assay for different combination of sublingual polymeric suggested that Rizatriptan film with 3% weight by volume and 30% by weight by volume of electrospun polymer PVP is the best combination... 

    Photo-induced growth of silver nanoparticles using UV sensitivity of cellulose fibers

    , Article Applied Surface Science ; Volume 258, Issue 7 , 2012 , Pages 2373-2377 ; 01694332 (ISSN) Omrani, A. A ; Taghavinia, N ; Sharif University of Technology
    A simple method has been demonstrated to grow silver nanoparticles on the surface of cellulose fibers. The preparation is based on photo-activation of surface by ultraviolet (UV) photons, followed by chemical reduction of silver nitrate. It is found that the concentration of silver nitrate in the solution is not a determining factor, while UV intensity affects the rate of initial growth and determines the final concentration of the loaded silver. We explain the phenomena based on a model including the number of reducing sites on the surface of cellulose fibers activated by UV photons, and a release mechanism that causes a slow rate of dissolution of silver back into the solution  

    Dendritic multi-walled carbon nanotube with thermoresponsive shells: A good carrier for anticancer drugs

    , Article Journal of Industrial and Engineering Chemistry ; Volume 35 , 2016 , Pages 332-340 ; 1226086X (ISSN) Pourjavadi, A ; Mazaheri Tehrani, Z ; Shirvani, T ; Doulabi, M ; Bumajdad, A ; Sharif University of Technology
    Korean Society of Industrial Engineering Chemistry 
    In this research, multi-walled carbon nanotubes (MWCNTs) were modified by dendritic macromonomer. Herein, polyamidoamine with acrylamide end groups was incorporated on MWCNTs. Afterwards, poly(N-isopropylacrylamide), (PNIPAM), was grafted on polyamidoamine in a facile synthesis. Then, doxorubicin as anticancer drug was loaded on this nanocarrier. The drug release was studied at below and above the lower critical solution temperature of PNIPAM, (LCST 32 °C), 27 °C and 37 °C, respectively. At 37 °C (body temperature) the polymer shell dehydrated and the drug release increased. The profile of drug release was expressed by Higuchi's equation which indicated that the drug release mechanism was... 

    Magnetic nanoparticles-loaded PLA/PEG microspheres as drug carriers

    , Article Journal of Biomedical Materials Research - Part A ; Vol. 103, issue. 5 , SEP , 2014 , p. 1893-1898 Frounchi, M ; Shamshiri, S ; Sharif University of Technology
    Surface-modified magnetite (Fe3O4) nanoparticles with an average size of 22 nm were prepared. The nanoparticles had a saturation magnetization of 50.7 emu g-1. Then magnetite and drug-loaded microspheres of poly (lactic acid)/poly (ethylene glycol) were prepared at various compositions. The microspheres were spherical in shape and had smooth surface. The diameter size of the microspheres ranged between about 0.2 and 4 μm. Doxorubicin hydrochloride for cancer treatment was the drug that loaded into the microspheres. The prepared microspheres were characterized by FTIR, XRD, VSM, SEM and drug-release measurements. It was found that the drug cumulative release percentage was proportional to... 

    Examination of chondroitinase ABC I immobilization onto dextran-coated Fe3O4 nanoparticles and its in-vitro release

    , Article Journal of Biotechnology ; Volume 309 , 2020 , Pages 131-141 Askaripour, H ; Vossoughi, M ; Khajeh, K ; Alemzadeh, I ; Sharif University of Technology
    Elsevier B.V  2020
    Chondroitinase ABC I (cABC I) has received notable attention in treatment of spinal cord injuries and its application as therapeutics has been limited due to low thermal stability at physiological temperature. In this study, cABC I enzyme was immobilized on the dextran-coated Fe3O4 nanoparticles through physical adsorption to improve the thermal stability. The nanoparticles were characterized using XRD, SEM, VSM, and FTIR analyses. Response surface methodology and central composite design were employed to assess factors affecting the activity of immobilized cABC I. Experimental results showed that pH 6.3, temperature 24 °C, enzyme/support mass ratio 1.27, and incubation time 5.7 h were the...