Sharif Digital Repository

Resistive pulse sensing (RPS) has proved to be a viable method for detection and characterization of micro and nano particles. This method works based on ionic current variation inside nanopores. Modern fabrication methods have introduced different nanopore geometries for resistive pulse sensors therefore studing the effects of geometry on sensing performance of nanaopores is important. Numerical simulation has been used to study a wide variation of nanopore’s geometry configurations and study the physics behind this phenomena. Based on the results, numerical simulation could be used as a fast and easy tool for size determination for nanopore. To compare the sensing performance of different... 

The advent of nanopore-based sensors based on resitive pulse sensing gave rise to a remarkable breakthrough in the detection and characterization of nanoscale species. The sensors can detect the species’concentration, size, and charge using the resistive pulse characteristics. Some strong correlations have been reported between the resitive pulse characteristics and the particle’s geometrical and physical properties. These correlations are commonly used to obtain information about the particles in commercial devices and research setups. The correlations, however, do not consider the simultaneous effect of influential factors such as particle shape, charge, and off-axis translocation, which... 

The aim of the current research is to study the process of making a solidstate nanopore by molding from PDMS polymer and to make a laboratory sample of a solidstate nanopore manufacturing device using this method. Solid-state nanopores are used to control ion transport in microfluidic channels,lab-on-a-chip detection to study nucleic acids and proteins, desalination, nanofluidic transistors,single-cell sensing tools, and particle classification. In general, the smaller the nanopore, the shorter the length and the higher the mechanical stability, the better the performance. In this research, chips have been made on which there is a blade with a sharpness of 10 nanometers and a height of 10... 

Over the last few years, exploiting particle sensing systems for micro-nanoparticles has grabbed much attention. Attaining the physical properties of particles using resistive pulse sensing has been one of the utmost applicable methods of sensing particles. Pores are pivotal elements of systems based on resistive pulse sensing. Two electrodes are placed at both sides of the pore, filling the containers with an electrolyte solution. Pulses of particle translocation across the pore can be recorded by applying a voltage across the electrodes. In more developed versions of resistive pulse sensing systems, pore size is tunable to attain polydisperse particles within a dispersion. In subsequent... 

Detecting small particles is one of the needs of researchers. Industrial and research developments in nano and biotechnology expands the need of suitable equipments. One of the challenges in this field is detecting the qualitative and quantitative properties in the sample. Until today there are numerous methods to detect the properties of the particles and different commercial machines are presented for this purpose. In this method, based on one the methods of detecting particles, called resistive pulse sensing, a mechanism is composed and by its help 7 um and 800 to 2000 nm particles are distinguished separately. This sensor has two important parts: the fluid and the electronic. In the...