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respiratory-gated-radiotherapy
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Modeling and optimization of respiratory-gated partial breast irradiation with proton beams - A Monte Carlo study
, Article Computers in Biology and Medicine ; Volume 147 , 2022 ; 00104825 (ISSN) ; Vosoughi, N ; Mahani, H ; Sharif University of Technology
Elsevier Ltd
2022
Abstract
The selection of a suitable duty factor (DF) remains a major challenge in respiratory-gated treatments. Therefore, this study aims at presenting a new methodology for fast optimizing the gating window width (duty factor (DF)) in respiratory-gated proton partial breast irradiation (PBI). To do so, GATE Monte Carlo simulations were performed for various target sizes and locations in supine and prone positions. Three different duty factors of 20, 25, and 33% were considered. Sparing factors (SF) for four organs-at-risk (OARs) were then assessed. The weighted-sum method was employed to search for an optimal DF. The results indicate that an SF higher than unity was obtained for all plans. The SF...