Sharif Digital Repository

Functional endoscopic sinus surgery (FESS) is performed to treat sinusitis when treatment with medication fails. In the present study, three different virtual maxillary sinus endoscopic surgeries were performed on a realistic 3-D computational model of the nasal cavity of an adult male under the supervision of a specialist. They included only uncinectomy, uncinectomy + 8mm Middle Meatal Antrostomy (MMA) and uncinectomy + 18 mm MMA. Simulations were performed for two human activity respiratory rates, including rest and moderate activities, and effects of different surgeries and respiratory rates on maxillary sinus were investigated. It was found that after endoscopic sinus surgery, the volume... 

This study uses a 5-lobe symmetric model to investigate total, lobar and generational particle deposition fractions in the lungs during successive cycles. It was found that for the particle size between 0.05 and 2 μm and the tidal volumes greater than 1000 ml, the effect of successive cycles helped predict more deposition fraction per cycle up to about 16% than that of a single cycle. The mentioned range of tidal volumes corresponds to light or heavy physical activities. Therefore, it can be understood that people, when physically active, exposed to particulate matter within the mentioned size range are at higher health risk as compared to both the resting state and the same state... 

Respiratory virus infections are among the most prevalent diseases in humans and contribute to morbidity and mortality in all age groups. Moreover, since they can evolve fast and cross the species barrier, some of these viruses, such as influenza A and coronaviruses, have sometimes caused epidemics or pandemics and were associated with more serious clinical diseases and even mortality. The recently identified Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a Public Health Emergency of International concern and has been associated with rapidly progressive pneumonia. To ensure protection against emerging respiratory tract... 

The present study provides an accurate simulation of velocity and temperature distributions of inhalation thermal injury in a human upper airway, including vestibule, nasal cavity, paranasal sinuses, nasopharynx, oropharynx, larynx, and upper part of main bronchus. To this end, a series of CT scan images, taken from an adult woman, was used to construct a three dimensional model. The airway walls temperature was adjusted according to existing in vivo temperature measurements. Also, in order to cover all breathing activities, five different breathing flow rates (10, 15, 20, 30, and 40. l/min) and different ambient air temperatures (100, 200, 300, 400, and 500. °C) were studied. Different flow... 

Objective(s): This study aims to evaluate combined proton nuclear magnetic resonance (1H NMR) spectroscopy and gas chromatography-mass spectrometry (GC-MS) metabolic profiling approaches, for discriminating between mustard airway diseases (MADs) and healthy controls and for providing biochemical information on this disease. Materials and Methods: In the present study, analysis of serum samples collected from 17 MAD subjects and 12 healthy controls was performed using NMR. Of these subjects, 14 (8 patients and 6 controls) were analyzed by GC-MS. Then, their spectral profiles were subjected to principal component analysis (PCA) and orthogonal partial least squares regression discriminant... 

Coronaviruses are a group of envelop viruses which lead to diseases in birds and mammals as well as human. Seven coronaviruses have been discovered in humans that can cause mild to lethal respiratory tract infections. HCoV-229E, HCoV-OC43, HCoV-NL63, and HCoV-HKU1 are the low-risk members of this family and the reason for some common colds. Besides, SARS-CoV, MERS-CoV, and newly identified SARS-CoV-2, which is also known as 2019-nCoV, are the more dangerous viruses. Due to the rapid spread of this novel coronavirus and its related disease, COVID-19, a reliable, simple, fast, and low-cost detection method is necessary for patient diagnosis and tracking worldwide. Human coronaviruses detection...