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retina-choroid-sclera-permeability
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Retina-Choroid-Sclera Permeability for Ophthalmic Drugs in the Vitreous to Blood Direction: Quantitative Assessment
, Article Pharmaceutical Research ; 2012 , Pages 1-19 ; 07248741 (ISSN) ; Abdekhodaie, M. J ; Cheng, Y. L ; Sharif University of Technology
Springer
2012
Abstract
Purpose: To determine the outward permeability of retina-choroid-sclera (RCS) layer for different ophthalmic drugs and to develop correlations between drug physicochemical properties and RCS permeability. Methods: A finite volume model was developed to simulate pharmacokinetics in the eye following drug administration by intravitreal injection. The RCS permeability was determined for 32 compounds by best fitting the drug concentration-time profile obtained by simulation with previously reported experimental data. Multiple linear regression was then used to develop correlations between best fit RCS permeability and drugs physicochemical properties. Results: The RCS drug permeabilities had...