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Synthesis of β-hydroxy dithiocarbamate derivatives via regioselective addition of dithiocarbamate anion to epoxide in water
, Article Canadian Journal of Chemistry ; Volume 84, Issue 11 , 2006 , Pages 1515-1519 ; 00084042 (ISSN) ; Saidi, M. R ; Sharif University of Technology
2006
Abstract
The reactions of different dithiocarbamate anions with epoxides were investigated in water. With this method, β-hydroxy dithiocarbamate derivatives were synthesized in high yields. The reaction was also carried out in DMF in the presence of lithium perchlorate with a simple work-up procedure, and the results are compared. © 2006 NRC
On the optimality of the genetic code, with the consideration of coevolution theory by comparison of prominent cost measure matrices
, Article Journal of Theoretical Biology ; Volume 235, Issue 3 , 2005 , Pages 318-325 ; 00225193 (ISSN) ; Shateri Najafabadi, H ; Hassani, K ; Ahmadi Nejad, H ; Torabi, N ; Sharif University of Technology
2005
Abstract
Statistical and biochemical studies have revealed non-random patterns in codon assignments. The canonical genetic code is known to be highly efficient in minimizing the effects of mistranslation errors and point mutations, since it is known that when an amino acid is converted to another due to error, the biochemical properties of the resulted amino acid are usually very similar to those of the original one. In this study, using altered forms of the fitness functions used in the prior studies, we have optimized the parameters involved in the calculation of the error minimizing property of the genetic code so that the genetic code outscores the random codes as much as possible. This work also...