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Retina-Choroid-Sclera Permeability for Ophthalmic Drugs in the Vitreous to Blood Direction: Quantitative Assessment
, Article Pharmaceutical Research ; 2012 , Pages 1-19 ; 07248741 (ISSN) ; Abdekhodaie, M. J ; Cheng, Y. L ; Sharif University of Technology
Springer
2012
Abstract
Purpose: To determine the outward permeability of retina-choroid-sclera (RCS) layer for different ophthalmic drugs and to develop correlations between drug physicochemical properties and RCS permeability. Methods: A finite volume model was developed to simulate pharmacokinetics in the eye following drug administration by intravitreal injection. The RCS permeability was determined for 32 compounds by best fitting the drug concentration-time profile obtained by simulation with previously reported experimental data. Multiple linear regression was then used to develop correlations between best fit RCS permeability and drugs physicochemical properties. Results: The RCS drug permeabilities had...
Retina-choroid-sclera permeability for ophthalmic drugs in the vitreous to blood direction: quantitative assessment
, Article Pharmaceutical research ; Volume 30, Issue 1 , January , 2013 , Pages 41-59 ; 1573904X (ISSN) ; Abdekhodaie, M. J ; Cheng, Y. L ; Sharif University of Technology
2013
Abstract
To determine the outward permeability of retina-choroid-sclera (RCS) layer for different ophthalmic drugs and to develop correlations between drug physicochemical properties and RCS permeability. A finite volume model was developed to simulate pharmacokinetics in the eye following drug administration by intravitreal injection. The RCS permeability was determined for 32 compounds by best fitting the drug concentration-time profile obtained by simulation with previously reported experimental data. Multiple linear regression was then used to develop correlations between best fit RCS permeability and drugs physicochemical properties. The RCS drug permeabilities had values that ranged over 3 ×...
Biomechanical simulation of eye-airbag impacts during vehicle accidents
, Article Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine ; Volume 232, Issue 7 , 2018 , Pages 699-707 ; 09544119 (ISSN) ; Zohoor, H ; Naserkhaki, S ; Sharif University of Technology
SAGE Publications Ltd
2018
Abstract
Airbags are safety devices in vehicles effectively suppressing passengers’ injuries during accidents. Although there are still many cases of eye injuries reported due to eye-airbag impacts in recent years. Biomechanical approaches are now feasible and can considerably help experts to investigate the issue without ethical concerns. The eye-airbag impact–induced stresses/strains in various components of the eye were found to investigate the risk of injury in different conditions (impact velocity and airbag pressure). Three-dimensional geometry of the eyeball, fat and bony socket as well as the airbag were developed and meshed to develop a finite element model. Nonlinear material properties of...