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    Computerized interpretation of cardiotocographs using kubli score

    , Article 4th European Conference of the International Federation for Medical and Biological Engineering, ECIFMBE 2008, Antwerp, 23 November 2008 through 27 November 2008 ; Volume 22 , 2008 , Pages 962-965 ; 16800737 (ISSN); 9783540892076 (ISBN) Krupa, N ; Hasan, F. M ; Mohd Ali, M. A ; Zahedi, E ; Sharif University of Technology
    The purpose of this work is to interpret cardiotocograph recordings by estimating kubli score in order to find out the presence of antepartum morbidity in cardiotocograph (CTG) recordings. The Kubli score is a tool used to evaluate a non-stress test (NST). It works very much like an Apgar Score in that there are 5 criteria to be assessed, baseline rate, amplitude of fluctuations, frequency of fluctuations, deceleration and acceleration pattern, and each will be assigned a score of 0, 1, or 2, for a maximum total of 10. The advantage of the Kubli score is that it is systematic and specific. This communication tool helps clinicians to have a visual image of the immediate fetal status. Using... 

    Stabilization exercises and their effect on fear-avoidance belief and disability in patients with recurrent nonspecific low back pain

    , Article Koomesh ; Volume 17, Issue 1 , 2015 , Pages 142-151 ; 16087046 (ISSN) Hedayati, R ; Kahrizi, S ; Parnianpour, M ; Bahrami, F ; Kazemnejad, A ; Mobini, B ; Sharif University of Technology
    Semnan University of Medical Sciences  2015
    Introduction: Therapeutic exercises are regarded as one of most important therapeutic interventions for patients with chronic low back pain. Stabilization exercises are among the most practical ones for these patients. Effects of these exercises on psychological factors associated with pain and consequential functional disabilities are still remained unknown. The purpose of this study was to assess the effect of stabilization exercises on fear of pain, movement and disability in patients with low back pain. Materials and Methods: Twenty one patients with recurrent non-specific low back pain (14 in experimental, 7 in control group) were participated in this study. The scores for fear of pain,... 

    MiR-361-5p as a promising qRT-PCR internal control for tumor and normal breast tissues

    , Article PLoS ONE ; Volume 16, Issue 6 June , 2021 ; 19326203 (ISSN) Ghanbari, S ; Salimi, A ; Rahmani, S ; Nafissi, N ; Sharifi Zarchi, A ; Mowla, S. J ; Sharif University of Technology
    Public Library of Science  2021
    Background: One of the most widely used evaluation methods in miRNA experiments is qRT-PCR. However, selecting suitable internal controls (IC) is crucial for qRT-PCR experiments. Currently, there is no consensus on the ICs for miRNA qRT-PCR experiments in breast cancer. To this end, we tried to identify the most stable (the least expression alteration) and promising miRNAs in normal and tumor breast tissues by employing TCGA miRNA-Seq data and then experimentally validated them on fresh clinical samples. Methods: A multi-component scoring system was used which takes into account multiple expression stability criteria as well as correlation with clinical characteristics. Furthermore, we... 

    Analysis and Evaluation of Intrusion Detection Systems Test Methods

    , M.Sc. Thesis Sharif University of Technology Amiri, Behnam (Author) ; Jahangir, Amir Hossein (Supervisor)
    Intrusion detection systems’ test and evaluation is an active research area on which many researchers have been working for years. A complete and comprehensive test methodology that can be applied in reasonable time and cost is important and useful both to evaluate a newly designed system and to compare two or more existing systems to select an appropriate system for a particular network. In this research, we first determine the critical features of an IDS and then inspect methods and effective parameters that may influence the test process and propose a method for testing intrusion detection systems. In the proposed test methodology we only examine critical features which lake of them cause... 

    The gait and energy efficiency of stance control knee-ankle-foot orthoses: A literature review

    , Article Prosthetics and Orthotics International ; Volume 40, Issue 2 , 2016 , Pages 202-214 ; 03093646 (ISSN) Rafiaei, M ; Bahramizadeh, M ; Arazpour, M ; Samadian, M ; Hutchins, S. W ; Farahmand, F ; Mardani, M. A ; Sharif University of Technology
    SAGE Publications Inc  2016
    Background: The use of knee-ankle-foot orthoses with drop locked knee joints produces some limitations for walking in subjects with quadriceps muscle weakness. The development of stance control orthoses can potentially improve their functionality. Objectives: The aim of this review was to compare the evidence of the effect of stance control orthoses to knee-ankle-foot orthoses with drop locked knee joints in improving kinematic variables and energy efficiency of walking by subjects with quadriceps muscle weakness caused by different pathologies. Study design: Literature review. Methods: Based on selected keywords and their composition, a search was performed in Google Scholar, PubMed,... 

    A clustering-based algorithm for de novo motif discovery in DNA sequences

    , Article 2017 24th Iranian Conference on Biomedical Engineering and 2017 2nd International Iranian Conference on Biomedical Engineering, ICBME 2017, 30 November 2017 through 1 December 2017 ; 2018 ; 9781538636091 (ISBN) Ebrahim Abadi, M. H ; Fatemizadeh, E ; Sharif University of Technology
    Motif discovery is a challenging problem in molecular biology and has been attracting researcher's attention for years. Different kind of data and computational methods have been used to unravel this problem, but there is still room for improvement. In this study, our goal was to develop a method with the ability to identify all the TFBS signals, including known and unknown, inside the input set of sequences. We developed a clustering method specialized as part of our algorithm which outperforms other existing clustering methods such as DNACLUST and CD-HIT-EST in clustering short sequences. A scoring system was needed to determine how much a cluster is close to being a real motif. Multiple... 

    Quasi-optimal EASI algorithm based on the Score Function Difference (SFD)

    , Article Neurocomputing ; Volume 69, Issue 13-15 , 2006 , Pages 1415-1424 ; 09252312 (ISSN) Samadi, S ; Babaie Zadeh, M ; Jutten, C ; Sharif University of Technology
    Equivariant adaptive separation via independence (EASI) is one of the most successful algorithms for blind source separation (BSS). However, the user has to choose non-linearities, and usually simple (but non-optimal) cubic polynomials are applied. In this paper, the optimal choice of these non-linearities is addressed. We show that this optimal non-linearity is the output score function difference (SFD). Contrary to simple non-linearities usually used in EASI (such as cubic polynomials), the optimal choice is neither component-wise nor fixed: it is a multivariate function which depends on the output distributions. Finally, we derive three adaptive algorithms for estimating the SFD and... 

    Discovering dominant pathways and signal-response relationships in signaling networks through nonparametric approaches

    , Article Genomics ; Volume 102, Issue 4 , October , 2013 , Pages 195-201 ; 08887543 (ISSN) Nassiri, I ; Masoudi Nejad, A ; Jalili, M ; Moeini, A ; Sharif University of Technology
    A signaling pathway is a sequence of proteins and passenger molecules that transmits information from the cell surface to target molecules. Understanding signal transduction process requires detailed description of the involved pathways. Several methods and tools resolved this problem by incorporating genomic and proteomic data. However, the difficulty of obtaining prior knowledge of complex signaling networks limited the applicability of these tools. In this study, based on the simulation of signal flow in signaling network, we introduce a method for determining dominant pathways and signal response to stimulations. The model uses topology-weighted transit compartment approach and comprises... 

    Development of a model to assess environmental performance, concerning HSE-MS principles

    , Article Environmental Monitoring and Assessment ; Volume 165, Issue 1-4 , June , 2010 , Pages 517-528 ; 01676369 (ISSN) Abbaspour, M ; Hosseinzadeh Lotfi, F ; Karbassi, A. R ; Roayaei, E ; Nikoomaram, H ; Sharif University of Technology
    The main objective of the present study was to develop a valid and appropriate model to evaluate companies' efficiency and environmental performance, concerning health, safety, and environmental management system principles. The proposed model overcomes the shortcomings of the previous models developed in this area. This model has been designed on the basis of a mathematical method known as Data Envelopment Analysis (DEA). In order to differentiate high-performing companies from weak ones, one of DEA nonradial models named as enhanced Russell graph efficiency measure has been applied. Since some of the environmental performance indicators cannot be controlled by companies' managers, it was... 

    Reliability and validity of the Foot and Ankle Outcome Score: A validation study from Iran

    , Article Clinical Rheumatology ; Volume 29, Issue 5 , 2010 , Pages 479-486 ; 07703198 (ISSN) Negahban, H ; Mazaheri, M ; Salavati, M ; Sohani, S. M ; Askari, M ; Fanian, H ; Parnianpour, M ; Sharif University of Technology
    The aims of this study were to culturally adapt and validate the Persian version of Foot and Ankle Outcome Score (FAOS) and present data on its psychometric properties for patients with different foot and ankle problems. The Persian version of FAOS was developed after a standard forward-backward translation and cultural adaptation process. The sample included 93 patients with foot and ankle disorders who were asked to complete two questionnaires: FAOS and Short-Form 36 Health Survey (SF-36). To determine test-retest reliability, 60 randomly chosen patients completed the FAOS again 2 to 6 days after the first administration. Test-retest reliability and internal consistency were assessed using... 

    Findings of DTI-p maps in comparison with T 2 /T 2 -FLAIR to assess postoperative hyper-signal abnormal regions in patients with glioblastoma 08 Information and Computing Sciences 0801 Artificial Intelligence and Image Processing

    , Article Cancer Imaging ; Volume 18, Issue 1 , 2018 ; 14707330 (ISSN) Beigi, M ; Safari, M ; Ameri, A ; Shojaee Moghadam, M ; Arbabi, A ; Tabatabaeefar, M ; Salighehrad, H ; Sharif University of Technology
    BioMed Central Ltd  2018
    Purpose: The aim of this study was to compare diffusion tensor imaging (DTI) isotropic map (p-map) with current radiographically (T 2/T 2 -FLAIR) methods based on abnormal hyper-signal size and location of glioblastoma tumor using a semi-automatic approach. Materials and methods: Twenty-five patients with biopsy-proved diagnosis of glioblastoma participated in this study. T 2, T 2 -FLAIR images and diffusion tensor imaging (DTI) were acquired 1 week before radiotherapy. Hyper-signal regions on T 2, T 2 -FLAIR and DTI p-map were segmented by means of semi-automated segmentation. Manual segmentation was used as ground truth. Dice Scores (DS) were calculated for validation of semiautomatic... 

    Cultural adaptation and validation of the persian version of the arthritis impact measurement scales 2-short form in patients with osteoarthritis of the knee

    , Article Disability and Rehabilitation ; Volume 31, Issue 25 , 2009 , Pages 2081-2087 ; 09638288 (ISSN) Askary Ashtiani, A. R ; Mousavi, J ; Montazeri, A ; Shamsollahi, S ; Parnianpour, M ; Sharif University of Technology
    Purpose.To translate and validate the Persian version of the Arthritis Measurement Scales 2-Short Form (AIMS2-SF) in patients with osteoarthritis (OA) of the knee. Method.The translation and cultural adaptation of the original questionnaire was carried out in accordance with published guidelines. One hundred and fourteen consecutive Persian-speaking patients with OA of the knee were participated in this study. The Short Form Health Survey (SF-36) and visual analogue scales (VAS) for pain and joint stiffness were used to test convergent validity of the Persian AIMS2-SF. In addition, 35 randomly selected patients were asked to complete the questionnaire 3 days later for the second time.... 

    Cytochrome 4Z1 expression is associated with unfavorable survival in triple-negative breast cancers

    , Article Breast Cancer: Targets and Therapy ; Volume 13 , 2021 , Pages 565-574 ; 11791314 (ISSN) Al Saraireh, Y. M ; Alshammari, F. O. F. O ; Youssef, A. M. M ; Al Tarawneh, F ; Al Sarayreh, S ; Almuhaisen, G. H ; Satari, A. O ; Al Shuneigat, J ; Alrawashdeh, H. M ; Sharif University of Technology
    Dove Medical Press Ltd  2021
    Purpose: Triple-negative breast cancer (TNBC) is characterized by high mortality rate, and its clinical management is difficult and complex. Therefore, there is a need for extensive efforts aimed at accelerating the discovery of novel therapies for TNBC. CYP4Z1 has been implicated in the development of breast cancer. The current study aimed at characterizing the expression of CYP4Z1 on TNBC. Materials and Methods: Using immunohistochemistry, CYP4Z1 expression was evaluated on 122 TNBC samples, four samples of breast cancers expressing ER, PR, and HER-2, and four samples of normal breast tissues. The association between the enzyme and various histopathological features and survival of... 

    Translation and validation study of the Persian version of the Arthritis Impact Measurement Scales 2 (AIMS2) in patients with osteoarthritis of the knee

    , Article BMC Musculoskeletal Disorders ; Volume 10, Issue 1 , 2009 ; 14712474 (ISSN) Mousavi, S. J ; Parnianpour, M ; Askary Ashtiani, A. R ; Hadian, M. R ; Rostamian, A ; Montazeri, A ; Sharif University of Technology
    Background. The Arthritis Impact Measurement Scales 2 (AIMS2) has not been translated and validated for Persian-speaking patients with osteoarthritis of the knee. This was to provide a validated instrument to measure functional disability and health-related quality of life in patients with osteoarthritis of the knee in Iran. The aim of this study was to culturally adapt and validate the AIMS2 for Persian-speaking patients with osteoarthritis of the knee in Iran. Methods. A consecutive sample of patients with knee osteoarthritis were asked to complete the AIMS2, the Short Form Health Survey (SF-36) and four visual analog scales for pain, joint stiffness, patient's and physician's global... 

    Towards obtaining more information from gas chromatography-mass spectrometric data of essential oils: An overview of mean field independent component analysis

    , Article Journal of Chromatography A ; Volume 1217, Issue 29 , 2010 , Pages 4850-4861 ; 00219673 (ISSN) Jalali Heravi, M ; Parastar, H ; Sereshti, H ; Sharif University of Technology
    Mean field independent component analysis (MF-ICA) along with other chemometric techniques was proposed for obtaining more information from multi-component gas chromatographic-mass spectrometric (GC-MS) signals of essential oils (mandarin and lemon as examples). Using these techniques, some fundamental problems during the GC-MS analysis of essential oils such as varying baseline, presence of different types of noise and co-elution have been solved. The parameters affecting MF-ICA algorithm were screened using a 25 factorial design. The optimum conditions for MF-ICA algorithm were followed by deconvolution of complex GC-MS peak clusters. The number of independent components (ICs) (chemical... 

    Delivery of melittin-loaded niosomes for breast cancer treatment: an in vitro and in vivo evaluation of anti-cancer effect

    , Article Cancer Nanotechnology ; Volume 12, Issue 1 , 2021 ; 18686958 (ISSN) Dabbagh Moghaddam, F ; Akbarzadeh, I ; Marzbankia, E ; Farid, M ; khaledi, L ; Reihani, A. H ; Javidfar, M ; Mortazavi, P ; Sharif University of Technology
    BioMed Central Ltd  2021
    Background: Melittin, a peptide component of honey bee venom, is an appealing candidate for cancer therapy. In the current study, melittin, melittin-loaded niosome, and empty niosome had been optimized and the anticancer effect assessed in vitro on 4T1 and SKBR3 breast cell lines and in vivo on BALB/C inbred mice. "Thin-layer hydration method" was used for preparing the niosomes; different niosomal formulations of melittin were prepared and characterized in terms of morphology, size, polydispersity index, encapsulation efficiency, release kinetics, and stability. A niosome was formulated and loaded with melittin as a promising drug carrier system for chemotherapy of the breast cancer cells....