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seminal-plasma
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Metabolic profiling of seminal plasma from teratozoospermia patients
, Article Journal of Pharmaceutical and Biomedical Analysis ; Volume 178 , January , 2020 ; Chashmniam, S ; Nobakht, F ; Amini, M ; Javidi, A ; Minai Tehrani, A ; Arjmand, B ; Gilany, K ; Sharif University of Technology
Elsevier B. V
2020
Abstract
Teratozoospermia is one of conditions that can cause male infertility. The mechanism of teratozoospermia remains unclear. The knowledge of the metabolites in human seminal plasma (HSP) is meaningful for the pathological study of teratozoospermia. Analysis of changed metabolites in HSP can help understand the cellular mechanism, find the novel biomarkers and subsequently design a diagnosis test. In this study, the analysis of samples performed by proton nuclear magnetic resonance spectroscopy (1H NMR spectroscopy) to identify the various metabolites, with the aim of finding metabolic profiles and biomarkers related to male infertility. Eighteen de-regulated metabolites were identified in...
Fourier transform infrared spectroscopy: A potential technique for noninvasive detection of spermatogenesis
, Article Avicenna Journal of Medical Biotechnology ; Vol. 6, Issue. 1 , 2014 , pp. 47-52 ; ISSN: 2008-4625 ; Moazeni Pouracil, R. S ; Reza Sadeghi, M ; Sharif University of Technology
Abstract
Background: The seminal plasma is an excellent source for noninvasive detection of spermatogenesis. The seminal plasma of normospermic and azoospermic men has been analyzed for detection of spermatogenesis. Methods: Optical spectroscopy (Attenuated Total Reflectance-Infrared spectroscopy (ATR-IR) and Fourier Transform infrared spectroscopy (FT-IR) has been used to analyze the seminal plasma and the metabolome of seminal plasma for detection of spermatogenesis. Results The seminal plasma of normospermic and azoospermic men has been analyzed by ATR-IR. The results show that there is a pattern variation in the azoospermic men compared to normospermic men. However, the seminal plasma is too...
Metabolomics fingerprinting of the human seminal plasma of asthenozoospermic patients
, Article Molecular Reproduction and Development ; Vol. 81, Issue. 1 , 2014 , pp. 84-86 ; ISSN: 1098-2795 ; Moazeni-Pourasil, R. S ; Jafarzadeh, N ; Savadi-Shiraz, E ; Sharif University of Technology
Abstract
It is estimated that 20% of couples are infertile, and half of these infertility cases are linked to men. One of conditions that can affect male fertility is asthenozoospermia. We applied Raman spectroscopy to the analysis of the metabolome of the human seminal plasma, and used chemometrics on the patterns of Raman spectra obtained. Significant changes were observed in the metabolome of the human seminal plasma of asthenozoospermic patients