Sharif Digital Repository

Microfluidic concentration gradient generators (μCGGs) are indispensable parts of many emerging lab-on-a-chip platforms for biological studies and drug delivery applications. Most of the μCGGs reported in the literature can only generate the desired concentration gradients in a micron-sized sample (e.g., cells). As such, there is an unmet need to design a μCGG that can generate continuous concentration gradients of multi reagents (e.g., drugs) in a millimeter-sized sample (e.g., tissue). Herein, we report the proof-of-concept of this class of μCGG by combining a modified tree-like CGG with a micromixer. By conducting both experimental investigation and numerical analysis, we show that the... 

In this paper, the sensitivity analysis is applied to the development of high performance adaptive hydraulic mounts. The analysis allows us to select the most effective design parameters for tuning an adaptive mount to different road and engine conditions. It is shown that in the low frequency road excitation, the upper chamber compliance and inertia of the fluid column in the inertia track are the most influential properties in changing the dynamic stiffness of the hydraulic mount. These properties for the high frequency engine excitations are the upper compliance and the inertia of the fluid column of the decoupler. For tuning the adaptive mount to different road and engine excitation, a... 

Increasing demand of fresh water, and limitation water resources, with respect to world economic growth brings up the importance of utilization of saline water. At the current research the sensitivity analysis of ROSA was conducted. For this analysis, a single stage reverse osmosis is designed for well water specifi cation in southern Tehran under following condition: Feed fl ow: 40 m3/h and membrane Element: BW30–400 FR. The sensitivity analyses for all chemical element of base water were performed. As a result of sensitivity analysis shortest sensitivity gap, belongs to boron, and longest sensitivity gap, belongs to calcium. Which refl ects, under the same conditions, the least element to... 

Ontology Alignment is a process for finding related entities of different ontologies. This paper discusses the results of our research in this area. One of them is a formulation for a new structural measure which extends famous related works. In this measure with a special attention to the transitive properties, it is tried to increase recall with less harm on precision. Second contribution is a new method for compound measure creation without any need to the mapping extraction phase. Effectiveness of these ideas is discussed and quantitative evaluations are explained in this paper. Copyright © 2006, Hassan Abolhassani, Babak Bagheri Hariri, & Seyed H. Haeri  

In the last decade, many potent analytical methods have been utilized to find the approximate solution of nonlinear differential equations. Some of these methods are energy balance method (EBM), homotopy perturbation method (HPM), variational iteration method (VIM), amplitude frequency formulation (AFF), and max-min approach (MMA). Besides the methods mentioned above, the Akbari-Ganji method (AGM) is a highly efficient analytical method to solve a wide range of nonlinear equations, including heat transfer, mass transfer, and vibration problems. In this study, it was constructed the approximate analytic solution for movement of two mechanical oscillators by employing the AGM. In the derived... 

A compact, low power, clock frequency doubler circuit with no external devices designed and manufactured in a 0.5um CMOS technology. Proposed circuit generates a 4.096MHz output clock frequency from a 2.048MHz input clock while an automatic duty cycle control circuit reduces the sensitivity of the duty cycle of output clock to the duty cycle of input signal or process and temperature we variations. For this purpose, an accurate delayed clock is generated. structure besides MOSFET capacitors offers a impact and low power circuit. The area of the circuit is 0.08mm2 while consumes 380uArms SV power supply and drives 15pF capacitor load. Measured output duty cycle shows a variance of 2.7% from... 

In this paper, we have discussed the results of sensitivity analysis in a payoff matrix of the Matching Pennies game. After representing the game as a LP model, the sensitivity analysis of the elements of the payoff matrix is presented. The game value and the optimal strategies for different values of parameters are determined and compared  

An algorithm is proposed to optimize the performance of multiphase structures (composites) under elastodynamic loading conditions. The goal is to determine the distribution of material in the structure such that the time-averaged total stored energy of structure is minimized. A penalization strategy is suggested to avoid the checkerboard instability, simultaneously to generate near 0-1 topologies. As a result of this strategy, the solutions of presented algorithm are sufficiently smooth and possess the regularity of H1 function space. A simple method for the continuum adjoint sensitivity analysis of the corresponding PDE-constrained optimization problem is presented. It is general and can be... 

In this investigation a theoretical model based on artificial neural network (ANN) has been developed to predict porosity percent and correlate the chemical composition and cooling rate to the amount of porosity in Al-Si casting alloys. In addition, the sensivity analysis was performed to investigate the importance of the effects of different alloying elements, composition, grain refiner, modifier and cooling rate on porosity formation behavior of Al-Si casting alloys. By comparing the predicted values with the experimental data, it is demonstrated that the well-trained feed forward back propagation ANN model with eight nodes in hidden layer is a powerful tool for prediction of porosity... 

In this paper, we have discussed the results of sensitivity analysis in a payoff matrix of the Matching Pennies game. After representing the game as a LP model, the sensitivity analysis of the elements of the payoff matrix is presented. The game value and the optimal strategies for different values of parameters are determined and compared  

In this study, a neural network (NN) modeling approach has been used to predict the mechanical and geometrical behaviors of mouse embryo cells. Two NN models have been implemented. In the first NN model dimple depth (w), dimple radius (a) and radius of the semi-circular curved surface of the cell (R) were used as inputs of the model while indentation force (f) was considered as output. In the second NN model, indentation force (f), dimple radius (a) and radius of the semi-circular curved surface of the cell (R) were considered as inputs of the model and dimple depth was predicted as the output of the model. In addition, sensitivity analysis has been carried out to investigate the influence... 

Tehran is one of the most polluted cities in Middle East which during winter extremely high levels of particulate matter (PM) occurs due to frequent stable weather episodes. This study aims to identify major sources of PM and quantify effectiveness of possible control measures and strategies during these episodes. The Brute Force Method (BFM) with Community Multiscale Air Quality model (CMAQ) was implemented to estimate the contributions from major local anthropogenic sources on PM levels. In this regard several scenarios including the effect of existing governmental policies and regulations to upgrade vehicles emission standards were investigated. Emission due to the existing condition and... 

The emerging environmental consequences of overdependence on fossil fuels have pushed many countries to invest in clean and renewable sources of power. Countries like Iran where these sources can be found in abundance can take advantage of this potential to reduce their dependence on fossil fuels. This study investigated the feasibility of the standalone use of a hybrid renewable energy system (HRES) to power buildings in the Bostegan village in the Hormozgan province of Iran. Technical, economic, and environmental assessments were performed with the help of the Hybrid Optimization of Multiple Energy Resources (HOMER) software, and the optimal configuration for the system components was... 

The emerging environmental consequences of overdependence on fossil fuels have pushed many countries to invest in clean and renewable sources of power. Countries like Iran where these sources can be found in abundance can take advantage of this potential to reduce their dependence on fossil fuels. This study investigated the feasibility of the standalone use of a hybrid renewable energy system (HRES) to power buildings in the Bostegan village in the Hormozgan province of Iran. Technical, economic, and environmental assessments were performed with the help of the Hybrid Optimization of Multiple Energy Resources (HOMER) software, and the optimal configuration for the system components was... 

Influence of backside coating parameters on dynamic response of AM-AFM is modeled. Timoshenko based beam model is used and the general nonlinear interaction force is enclosed. The coupled ODEs of motion are achieved. The mode shapes are determined for coated cantilever and the natural frequency of each mode is validated with experimental results. It is showed a shorter cantilever with tip mass have better accuracy and inelastic and massless assumptions are not proper choice for modelling of the coating. The assumed mode method is used to determine time response of system for faraway and scanning condition of AM-AFM. Amplitude of response is calculated by FFT of time domain. Sensitivity... 

Despite advancements in developing physics-based formulations to estimate the sheet-flow travel time (tSHF), the quantification of the relative impacts of influential parameters on tSHF has not previously been considered. In this study, a brief review of the physics-based formulations to estimate tSHF including kinematic wave (K-W) theory in combination with Manning's roughness (K-M) and with Darcy-Weisbach friction formula (K-D) over single and multiple planes is provided. Then, the relative significance of input parameters to the developed approaches is quantified by a density-based global sensitivity analysis (GSA). The performance of K-M considering zero-upstream and uniform flow depth... 

In recent years, the management of health systems is a main concern of governments and decision-makers. Home health care is one of the newest methods of providing services to patients in developed societies that can respond to the individual lifestyle of the modern age and the increase of life expectancy. The home health care routing and scheduling problem is a generalized version of the vehicle routing problem, which is extended to a complex problem by adding special features and constraints of health care problems. In this problem, there are multiple stakeholders, such as nurses, for which an increase in their satisfaction level is very important. In this study, a mathematical model is...