Search for: serpentine-microchannels
Secondary flows, mixing, and chemical reaction analysis of droplet-based flow inside serpentine microchannels with different cross sections, Article Langmuir ; Volume 37, Issue 17 , 2021 , Pages 5118-5130 ; 07437463 (ISSN) ; Madadelahi, M ; Dizani, M ; Shamloo, A ; Sharif University of Technology
American Chemical Society 2021
Chemical bioreactions are an important aspect of many recent microfluidic devices, and their applications in biomedical science have been growing worldwide. Droplet-based microreactors are among the attractive types of unit operations, which utilize droplets for enhancement in both mixing and chemical reactions. In the present study, a finite-volume-method (FVM) numerical investigation is conducted based on the volume-of-fluid (VOF) applying for the droplet-based flows. This multiphase computational modeling is used for the study of the chemical reaction and mixing phenomenon inside a serpentine microchannel and explores the effects of the aspect ratio (i.e., AR = height/width) of...
Newtonian and generalized Newtonian reacting flows in serpentine microchannels: pressure driven and centrifugal microfluidics, Article Journal of Non-Newtonian Fluid Mechanics ; Volume 251 , January , 2018 , Pages 88-96 ; 03770257 (ISSN) ; Shamloo, A ; Sharif University of Technology
Elsevier B.V 2018
This paper presents a comprehensive 3D numerical simulation of reacting flows in micro scale dimension through centrifugal, or Lab-On-a-CD (LOCD), and pressure-driven, or Lab-On-a-Chip (LOC) devices. Three different serpentine channel configurations (rectangular, triangular and sinusoidal) are investigated. In these configurations, two chemical species enter from two inlets and according to an irreversible chemical reaction, start yielding other species. Both Newtonian and generalized Newtonian fluids are considered in the simulations and the results are compared for both LOC and LOCD devices. Besides, the effects of different parameters such as the aspect ratio of channels’ cross section,...
Design and fabrication of a two-phase diamond nanoparticle aided fast PCR device, Article Analytica Chimica Acta ; Volume 1068 , 2019 , Pages 28-40 ; 00032670 (ISSN) ; Ghazimirsaeed, E ; Shamloo, A ; Sharif University of Technology
Elsevier B.V 2019
Polymerase Chain Reaction (PCR) is an important and prevalent technique in biotechnology because of its crucial role in cloning DNA fragments and diagnostic applications. In the present study, a high-throughput two-phase PCR device is designed and fabricated which utilizes a serpentine microchannel together with a spiral structure. The former is for the droplet-generation and mixing and the latter is for the thermal cycling process. Moreover, the effect of diamond nanoparticles (diamondNP) on the performance of PCR is also investigated while using commercial PCR devices and the fabricated PCR device designed in this study. Using numerical simulation, it is shown that within the simple and...