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smart-nanocarriers
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Design of Oxidative Stress Nanoparticles for Targeted drug Delivery to the Posterior Segment of the Eye and Breast Cancer
, Ph.D. Dissertation Sharif University of Technology ; Abdekhodaei, Mohammad Jafar (Supervisor) ; Baharvand, Hossein (Supervisor) ; Satarian, Leila ($item.subfieldsMap.e) ; Sadeghi, Hamid ($item.subfieldsMap.e)
Abstract
The oxidation-reduction (redox) responsive micelle system is based on a diselenide-containing triblock copolymer, poly(ε-caprolactone)-bis(diselenide-methoxy poly(ethylene glycol)/poly(ethylene glycol)-folate) [PCL-(SeSe-mPEG/PEG-FA)2]. Resulting in the development of tumor-targeted delivery for hydrophobic anticancer drugs. The diselenide bond, as redox-sensitive linkage, was designed, so it is located at the hydrophilic/hydrophobic hinge to allow complete micelles collapse and efficient drug release, in redox environments. The amphiphilic block copolymers self-assembled into micelles at concentrations above the critical micelle concentration (CMC) in an aqueous environment. Dynamic light...
Synthesis and Characterization of Transition Metal Complexes Supported on Carbon-Based Nanocomposites and Their Application as Gene and Drug Delivery Systems
, Ph.D. Dissertation Sharif University of Technology ; Bagherzadeh, Mojtaba (Supervisor)
Abstract
In this dissertation, an attempt has been made to optimize some smart nanocarriers and the controllable release of drug (doxorubicin) and genetic material (plasmid CRISPR). Regarding, some metal nanoparticles, metal-organic frameworks, transition metal complexes, graphene oxide, and functionalized carbon nanotubes have been synthesized and also characterized and their hybrids and nanocomposites have been prepared successfully. All the abovementioned nanomaterials were designed and synthesized due to achieve biodegradable, biocompatible, higher positive surface potential, lower cytotoxicity, better responsivity to stimulus, and greener compounds. Doxorubicin and plasmid CRISPR has been...