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Curcumin incorporated PVA-borax dual delivery hydrogels as potential wound dressing materials—Correlation between viscoelastic properties and curcumin release rate
, Article Journal of Applied Polymer Science ; Volume 135, Issue 45 , 2018 ; 00218995 (ISSN) ; Pircheraghi, G ; Bagheri, R ; Sharif University of Technology
John Wiley and Sons Inc
2018
Abstract
Poly(vinyl alcohol) (PVA) is a biocompatible polymer which can be physically crosslinked by Borax to form hydrogel. PVA-Borax (PB) hydrogel is a promising candidate for drug delivery system. Therefore, it is necessary to find the quantitative relationship between drug release rate and network structure of PB hydrogels to predict and control drug release rate. In this work, at first step the optimum ratio of Borax: PVA was determined by studying the interactions between PVA chains and Borax molecules by means of Fourier transform infrared spectroscopy, while viscoelastic properties of prepared PB hydrogels were measured in the oscillatory shear flow field. In the following, curcumin as a...