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solid-state-nanopore
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Design and Manufacturing of a Setup for Solid-state Nanopore Fabrication
, M.Sc. Thesis Sharif University of Technology ; Akbari, Javad (Supervisor) ; Taghipour, Mojtaba (Supervisor)
Abstract
The aim of the current research is to study the process of making a solidstate nanopore by molding from PDMS polymer and to make a laboratory sample of a solidstate nanopore manufacturing device using this method. Solid-state nanopores are used to control ion transport in microfluidic channels,lab-on-a-chip detection to study nucleic acids and proteins, desalination, nanofluidic transistors,single-cell sensing tools, and particle classification. In general, the smaller the nanopore, the shorter the length and the higher the mechanical stability, the better the performance. In this research, chips have been made on which there is a blade with a sharpness of 10 nanometers and a height of 10...
Tuning electrokinetic flow, ionic conductance, and selectivity in a solid-state nanopore modified with a pH-responsive polyelectrolyte brush: A molecular theory approach
, Article Journal of Physical Chemistry C ; Volume 124, Issue 34 , 2020 , Pages 18513-18531 ; Saidi, M. H ; Moosavi, A ; Kröger, M ; Sharif University of Technology
American Chemical Society
2020
Abstract
We use an efficient molecular theory approach to study electrokinetic flow within a pH-responsive nanopore grafted with a polyelectrolyte (PE) brush. The flow rate, migration and convective conductance, electric potential and velocity fields, species distributions and the degree of ionization of the weak PE functional groups and nanopore selectivity are obtained and interpreted while considering pH-induced surface charges. The theory is generally based on writing the overall free energy of the system including the entropies arising from the conformations of flexible, excluded volume chains, the mixing of mobile species, electrostatic contribution, and the free energy due to the chemical...