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A novel technique to semi-quantitatively study the stability of emulsions and the kinetics of the coalescence under different dynamic conditions
, Article Colloids and Surfaces A: Physicochemical and Engineering Aspects ; Vol. 460 , 2014 , pp. 327-332 ; ISSN: 09277757 ; Orr, R ; Bastani, D ; Javadi, A ; Lotfi, M ; Miller, R ; Sharif University of Technology
Abstract
The kinetics of coalescence is studied experimentally using a new technique for tracking the process in the bulk phase. For this aim, aqueous solutions of KSCN (colorless) and FeCl3 (light yellow) are used to make individual W/O emulsions. Any coalescence occurred between drops containing KSCN solution and those containing FeCl3 solution would combine these solutions. This leads to a reddish brown solution due to the formation of iron(III)thiocyanate. The intensity change of this red color with time represents the dynamics of coalescence occurring between drops of different emulsified aqueous droplets. The detector response to any changes in the system is recorded as a function of time. In...
Optimization, physicochemical characterization, and antimicrobial activity of a novel simvastatin nano-niosomal gel against E. coli and S. aureus
, Article Chemistry and Physics of Lipids ; Volume 234 , 2021 ; 00093084 (ISSN) ; Keramati, M ; Azadi, A ; Afzali, E ; Shahbazi, R ; chiani, M ; Norouzian, D ; Bakhshandeh, H ; Sharif University of Technology
Elsevier Ireland Ltd
2021
Abstract
Niosomes, as a kind of drug delivery system, is widely used for the topical delivery of lipophilic drugs. Optimization of niosomes plays an essential role in enhancing their therapeutic efficiencies. This study aims to prepare an optimized niosomal formulation of simvastatin (nSIM), a lipophilic member of statins, through the experiment (Response Surface methodology). Optimized niosomes were characterized in size, polydispersity index (PDI), entrapment efficiency (EE), stability, releasing pattern, and antimicrobial activity. The different molar ratio of surfactant and cholesterol were applied to prepare various formulation of simvastatin loaded niosome. Mean particle size and size...
Optimization, physicochemical characterization, and antimicrobial activity of a novel simvastatin nano-niosomal gel against E. coli and S. aureus
, Article Chemistry and Physics of Lipids ; Volume 234 , 2021 ; 00093084 (ISSN) ; Keramati, M ; Azadi, A ; Afzali, E ; Shahbazi, R ; chiani, M ; Norouzian, D ; Bakhshandeh, H ; Sharif University of Technology
Elsevier Ireland Ltd
2021
Abstract
Niosomes, as a kind of drug delivery system, is widely used for the topical delivery of lipophilic drugs. Optimization of niosomes plays an essential role in enhancing their therapeutic efficiencies. This study aims to prepare an optimized niosomal formulation of simvastatin (nSIM), a lipophilic member of statins, through the experiment (Response Surface methodology). Optimized niosomes were characterized in size, polydispersity index (PDI), entrapment efficiency (EE), stability, releasing pattern, and antimicrobial activity. The different molar ratio of surfactant and cholesterol were applied to prepare various formulation of simvastatin loaded niosome. Mean particle size and size...
Simvastatin-loaded nano-niosomes confer cardioprotection against myocardial ischemia/reperfusion injury
, Article Drug Delivery and Translational Research ; Volume 12, Issue 6 , 2022 , Pages 1423-1432 ; 2190393X (ISSN) ; Mousavi Niri , N ; Akbarzade, I ; Sharifi, M ; Aboutaleb, N ; Sharif University of Technology
Springer
2022
Abstract
Although simvastatin (SIM) has been proven to be a powerful agent against myocardial ischemia/reperfusion (MI/R) injury, poor water solubility, short half-life, and low bioavailability have made it futile while using conventional drug delivery system. Hence, this study aims to investigate therapeutic efficacy of SIM-loaded nano-niosomes on MI/R injury. Surface active agent film hydration method was used to synthesize nano-niosomes. The physicochemical properties of nano-niosomes were characterized using dynamic light scattering (DLS) and transmission electron microscopy (TEM). Moreover, niosomes were characterized in entrapment efficiency (EE) and releasing pattern. Male Wistar rats were...