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Advancement of sensor integrated organ-on-chip devices
, Article Sensors (Switzerland) ; Volume 21, Issue 4 , 2021 , Pages 1-44 ; 14248220 (ISSN) ; Hartse, B. X ; Niaraki Asli, A. E ; Taghavimehr, M ; Hashemi, N ; Abbasi Shirsavar, M ; Montazami, R ; Alimoradi, N ; Nasirian, V ; Ouedraogo, L. J ; Hashemi, N. N ; Sharif University of Technology
MDPI AG
2021
Abstract
Organ-on-chip devices have provided the pharmaceutical and tissue engineering worlds much hope since they arrived and began to grow in sophistication. However, limitations for their applicability were soon realized as they lacked real-time monitoring and sensing capabilities. The users of these devices relied solely on endpoint analysis for the results of their tests, which created a chasm in the understanding of life between the lab the natural world. However, this gap is being bridged with sensors that are integrated into organ-on-chip devices. This review goes in-depth on different sensing methods, giving examples for various research on mechanical, electrical resistance, and bead-based...