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spect-imaging
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Implementation of absolute quantification in small-animal SPECT imaging: Phantom and animal studies
, Article Journal of Applied Clinical Medical Physics ; Volume 18, Issue 4 , 2017 , Pages 215-223 ; 15269914 (ISSN) ; Vosoughi, N ; Tanha, K ; Assadi, M ; Ghafarian, P ; Rahmim, A ; Ay, M. R
John Wiley and Sons Ltd
2017
Abstract
Purpose: Presence of photon attenuation severely challenges quantitative accuracy in single-photon emission computed tomography (SPECT) imaging. Subsequently, various attenuation correction methods have been developed to compensate for this degradation. The present study aims to implement an attenuation correction method and then to evaluate quantification accuracy of attenuation correction in small-animal SPECT imaging. Methods: Images were reconstructed using an iterative reconstruction method based on the maximum-likelihood expectation maximization (MLEM) algorithm including resolution recovery. This was implemented in our designed dedicated small-animal SPECT (HiReSPECT) system. For...
In vivo SPECT imaging of tumors by 198,199Au-labeled graphene oxide nanostructures
, Article Materials Science and Engineering C ; Vol. 45 , 2014 , pp. 196-204 ; ISSN: 09284931 ; Akhavan, O ; Rahighi, R ; Aboudzadeh, M. R ; Karimi, E ; Afarideh, H ; Sharif University of Technology
Abstract
Graphene oxide (GO) sheets functionalized by aminopropylsilyl groups (8.0 wt.%) were labeled by 198,199Au nanoparticle radioisotopes (obtained through reduction of HAuCl4 in sodium citrate solution followed by thermal neutron irradiation) for fast in vivo targeting and SPECT imaging (high purity germanium-spectrometry) of tumors. Using instant thin layer chromatography method, the physicochemical properties of the amino-functionalized GO sheets labeled by 198,199Au NPs (198,199Au@AF-GO) were found to be highly stable enough in organic phases, e.g. a human serum, to be reliably used in bioapplications. In vivo biodistribution of the 198,199Au@AF-GO composite was investigated in rats bearing...
Detection of dopamine receptors using nanoscale dendrimer for potential application in targeted delivery and whole-body imaging: synthesis and in vivo organ distribution
, Article ACS Applied Bio Materials ; Volume 5, Issue 4 , 2022 , Pages 1744-1755 ; 25766422 (ISSN) ; Aminzadeh Jahromi, N ; Ali, V ; Ebrahimpour, A ; Salehian, E ; Shafiee Ardestani, M ; Seyedhamzeh, M ; Ahmadi, S ; Sharifi, E ; Ashrafizadeh, M ; Rabiee, N ; Makvandi, P ; Sharif University of Technology
American Chemical Society
2022
Abstract
Dopamine is one of the most important neurotransmitters released by neurons in the central nervous system, and a variety of neurological illnesses and mental disorders are associated with impairments in the secretion and functionality of dopamine. Dopamine, depending on the type of receptors, can act as a stimulant or an inhibitor. In this study, dendrimer-conjugated dopamine was utilized as a chelating agent for Technetium-99m to investigate the organ distribution of this compound in vivo using the single-photon emission computed tomography (SPECT) technique. For this purpose, dendrimers were synthesized using polyethylene glycol diacid and citric acid precursors, and dopamine was...