Loading...
Search for:
spiral-microchannel
0.004 seconds
Design and Fabrication of a Spiral Microchannel for High Resolution Blood Cell Separation
, M.Sc. Thesis Sharif University of Technology ; Saeedi, Mohammad Saeed (Supervisor) ; Taghipoor, Mojtaba (Co-Supervisor)
Abstract
In medical science, preparing a high purity sample of certain kinds of cells plays an important role in studying the characteristics and functionality of cells, detecting in vitro harmful pathogens and helping to find ways of preventing and treating diseases that cause cellular disorders in the human body. The goal of this research is to improve the spiral microchannel with stair-like cross section in order to separate white blood cells from whole blood. First, the efficiency of this method was evaluated numerically, using a developed finite element model. Then, the desired microchannel mold was made using the micromiling method, and we fabricated the chip using soft lithography and pasting...
Design and Simulation of a Spiral Based Microfluidic Device for Separation of Circulating Tumor Cells Using Tunable Nature of Viscoelastic Fluid
, M.Sc. Thesis Sharif University of Technology ; Saeedi, Mohammad Saeed (Supervisor)
Abstract
Nowadays, cancer, which has been mentioned as the disease of the century, is the second leading cause of death throughout the world, and its incidence is constantly increasing. Isolation of circulating tumor cells is one of the most critical steps in diagnosing and controlling cancer progression. Due to the rarity of cancer cells compared to other cells in the blood sample, the isolation process requires optimal and high-precision devices. With the advent of inertial microfluidics, the ability to control the particles movement, the processing of blood samples as quickly and accurately as possible, and the viability of cells with a high percentage, introduced microfluidic systems as a...
Spiral microchannel with stair-like cross section for size-based particle separation
, Article Microfluidics and Nanofluidics ; Volume 21, Issue 7 , 2017 ; 16134982 (ISSN) ; Kowsari Esfahan, R ; Saidi, M. S ; Firoozbakhsh, K ; Sharif University of Technology
Springer Verlag
2017
Abstract
Particle separation has a variety of applications in biology, chemistry and industry. Among them, circulating tumor cells (CTCs) separation has drawn significant attention to itself due to its high impact on both cancer diagnosis and therapeutics. In recent years, there has been growing interest in using inertial microfluidics to separate micro/nano particles based on their sizes. This technique offers label-free, high-throughput and efficient separation and can be easily fabricated. However, further improvements are needed for potential clinical applications. In this study, a novel inertial separation technique using spiral microchannel having stair-like cross section is introduced. The...
Parametric study on mixing process in an in-plane spiral micromixer utilizing chaotic advection
, Article Analytica Chimica Acta ; Volume 1022 , 2018 , Pages 96-105 ; 00032670 (ISSN) ; Shamloo, A ; Sharif University of Technology
Abstract
Recent advances in the field of microfabrication have made the application of high-throughput microfluidics feasible. Mixing which is an essential part of any miniaturized standalone system remains the key challenge. This paper proposes a geometrically simple micromixer for efficient mixing for high-throughput microfluidic devices. The proposed micromixer utilizes a curved microchannel (spiral microchannel) to induce chaotic advection and enhance the mixing process. It is shown that the spiral microchannel is more efficient in comparison to a straight microchannel, mixing wise. The pressure drop in the spiral microchannel is only slightly higher than that in the straight microchannel. It is...
Cancer Cell Separation Using Spiral Microchannel
, M.Sc. Thesis Sharif University of Technology ; Saidi, Mohmmad Said (Supervisor) ; Firoozbakhsh, Keykhosrow (Supervisor)
Abstract
Particle separation has a variety of applications in biology, chemistry and industry. Among them, circulating tumor cells (CTCs) separation has drawn significant attention to itself due to its high impact on both cancer diagnosis and therapeutics. In recent years, there has been growing interest in using inertial microfluidics to separate micro/nano particles based on their sizes. This technique offers label-free, high throughput, and efficient separation and can be easily fabricated. However, further improvements are needed for potential clinical applications. In this study, a novel inertial separation technique using spiral microchannel with stair-like cross section is introduced. The...
The coupled microfluidic microbial electrochemical cell as a self-powered biohydrogen generator
, Article Journal of Power Sources ; Volume 451 , 2020 ; Mardanpour, M. M ; Yaghmaei, S ; Sharif University of Technology
Elsevier B.V
2020
Abstract
Due to the importance of hydrogen as an effective antioxidant for its applications in therapy, this research reports the fabrication of a coupled microfluidic microbial electrochemical cell (MXC), including microfluidic microbial fuel cells (MFCs) and a microfluidic microbial electrolysis cell (MEC) series in order to perform it as a self-powered biohydrogen generator. Being able to be a platform of implantable medical devices, utilization a non-phatogenic strain of Escherichia coli as the biocatalyst in order to exploit the embodied energy from human blood and excrement and finally the use of cheap and facile materials (<$2 per device) are the exceptional features of the system. The...