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    Electrochemical oxidation of dopamine in the presence of sulfhydryl compounds: Application to the square-wave voltammetric detection of penicillamine and cysteine

    , Article Electrochimica Acta ; Volume 51, Issue 20 , 2006 , Pages 4271-4276 ; 00134686 (ISSN) Shahrokhian, S ; Bozorgzadeh, S ; Sharif University of Technology
    2006
    Abstract
    Electro-oxidation of dopamine at a glassy carbon electrode was investigated in the presence of some biologically important thiols (R-SH), e.g. cysteine and penicillamine. Results of cyclic voltammetric studies together with the spectrophotometric foundations via Ellman's test during the controlled-potential coulometry show a nucleophilic addition/reduction of thiol to the electrochemically generated dopaminoquinone by a 1 + 4 Michael addition. The resulting ring substituted substrate (as RS-form) is more easily oxidized leading to an increase in the anodic current of dopamine, which is proportional to the concentration of thiol. The square-wave voltammetry (SWV) were applied as a very...