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A viscoelastic model for axonal microtubule rupture
, Article Journal of Biomechanics ; Volume 48, Issue 7 , 2015 , Pages 1241-1247 ; 00219290 (ISSN) ; Manuchehrfar, F ; Rafii Tabar, H ; Sharif University of Technology
Elsevier Ltd
2015
Abstract
Axon is an important part of the neuronal cells and axonal microtubules are bundles in axons. In axons, microtubules are coated with microtubule-associated protein tau, a natively unfolded filamentous protein in the central nervous system. These proteins are responsible for cross-linking axonal microtubule bundles. Through complimentary dimerization with other tau proteins, bridges are formed between nearby microtubules creating bundles. Formation of bundles of microtubules causes their transverse reinforcement and has been shown to enhance their ability to bear compressive loads. Though microtubules are conventionally regarded as bearing compressive loads, in certain circumstances during...
Computational Modeling of Axonal Microtubule and Study the Effect of Cytoplasm on It under the Tension
, M.Sc. Thesis Sharif University of Technology ; Shamloo, Amir (Supervisor)
Abstract
Axon is an important part of the neuronal cells and axonal microtubules are bundles in axons.In axons, microtubules are coated with microtubule-associated protein tau, a natively unfolded filamentous protein in the central nervous system. These proteins are responsible for cross-linking axonal microtubule bundles. Through complimentary dimerization with other tau proteins, bridges are formed between nearby microtubules creating bundles. Formation of bundles of microtubules causes their transverse reinforcement and has been shown to enhance their ability to bear compressive loads. Though microtubules are conventionally regarded as bearing compressive loads, in certain circumstances such as in...
Three dimensional modeling of axonal microtubules
, Article 2014 21st Iranian Conference on Biomedical Engineering, ICBME 2014, 26 November 2014 through 28 November 2014 ; November , 2014 , Pages 298-302 ; 9781479974177 (ISBN) ; Shamloo, A ; Sharif University of Technology
Institute of Electrical and Electronics Engineers Inc
2014
Abstract
Axon is a filament in neuronal system and axonal microtubules are bundles in axons. In axons, microtubules are coated with microtubule-associated protein tau, a natively unfolded profuse filamentous protein in the central nervous system. These proteins are responsible for the cross-linked structure of the axonal microtubule bundles. Through complimentary dimerization with other tau proteins, bridges are formed to nearby microtubules to create bundles. The transverse reinforcement of microtubules by cross-linking to the cytoskeleton has been shown to enhance their ability to bear compressive loads. Though microtubules are conventionally regarded as bearing compressive loads, in certain...
Modeling of viscoelastic solid polymers using a boundary element formulation with considering a body load
, Article Advanced Materials Research, 7 January 2012 through 8 January 2012 ; Volume 463-464 , January , 2012 , Pages 499-504 ; 10226680 (ISSN) ; 9783037853634 (ISBN) ; Bahadori, M. R ; Shariyat, M ; Sharif University of Technology
Abstract
In this work, a boundary element formulation for 2D linear viscoelastic solid polymers subjected to body force of gravity has been presented. Structural analysis of solid polymers is one of the most important subjects in advanced engineering structures. From basic assumptions of the viscoelastic constitutive equations and the weighted residual techniques, a simple but effective boundary element formulation is implemented for standard linear solid (SLS) model. The SLS model provides an approximate representation of observed behavior of a real advanced polymer in its viscoelastic range. This approach avoids the use of relaxation functions and mathematical transformations, and it is able to...