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    Magnetic metal nanoparticles decorated ionic liquid with excellent antibacterial activity

    , Article Journal of Nanostructures ; Volume 10, Issue 3 , 2020 , Pages 613-623 Salari, H ; Karimi Asl, M ; Padervand, M ; Gholami, M. R ; Sharif University of Technology
    University of Kashan  2020
    Fe3O4 magnetic structure was synthesized with co-precipitation method. Surface of magnetic core was modified with hydrophobic BMIM[PF6] ionic liquid. The samples became antibacterial by loading gold, copper and silver nanoparticles and denoted as Fe3O4/IL/X (X=Ag, Au, Cu). X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray (EDX), thermal gravimetric analysis (TGA), Atomic absorption spectroscopy (AAS), Fourier transform infrared (FTIR) and vibration sample magnetometer (VSM) technics were applied for catalysts characterization, metal concentration analysis and morphology monitoring. Modified nanostructures were used for inactivation of Escherichia coli as... 

    Antibacterial and antifungal activity of methanolic extracts of Salix alba L. against various disease causing pathogens

    , Article Brazilian journal of biology = Revista brasleira de biologia ; Volume 83 , 2021 , Pages e243332- ; 16784375 (ISSN) Javed, B ; Farooq, F ; Ibrahim, M ; Abbas, H. A. B ; Jawwad, H ; Zehra, S. S ; Ahmad, H. M ; Sarwer, A ; Malik, K ; Nawaz, K ; Sharif University of Technology
    NLM (Medline)  2021
    The present study was aimed to manifest the antibacterial and antifungal activity of methanolic extracts of Salix alba L. against seven Gram-positive and Gram-negative bacterial pathogens e.g. Streptococcus pyogenes, Staphylococcus aureus (1), S. aureus (2), Shigella sonnei, Escherichia coli (1), E. coli (2) and Neisseria gonorrhoeae and three fungal isolates from the air such as Aspergillus terreus, A. ornatus, and Rhizopus stolonifer. Two different serotypes of S. aureus and E. coli were used. The agar well-diffusion method results showed the dose-dependent response of plant extracts against bacterial and fungal strains while some organisms were found resistant e.g. E. coli (1), S. sonnei,... 

    Synthesis and Preparation of Nanostructured Ag@SiO2 Core Shells with Different Morphologies and their Antibacterial Properties

    , Ph.D. Dissertation Sharif University of Technology Malekzadeh, Mahdieh (Author) ; Halali, Mohammad (Supervisor)
    In this study, silver nanoparticles (Ag NPs) with different morphologies were synthesize by physical and chemical methods. Spherical silver nanoparticles were synthesized by electro magnetic levitation melting approach, while silver nanoplates and nanorods were prepared by chemical reduction route. Ag NPs were then coated with thin porous silica shell. The dissolution behavior of synthesized Ag@SiO2 was investigated in PBS at 25, 37 and 55 °C. Spherical and triangular Ag@SiO2 were conjugated by Penicillin G molecules. The silver and penicillin contents of the synthesized nano-antibiotics were determined by ICP-OES and TGA analyses. The nanoparticles were characterized by X-ray diffraction... 

    Synthesis and Experimental Study of Organic-Metal Framework (MOF) Nanophotocatalists with Antibacterial Properties

    , M.Sc. Thesis Sharif University of Technology Rahmati, Ziba (Author) ; Vossoughi, Manouchehr (Supervisor) ; Abdi, Jafar (Co-Supervisor)
    MOFs are new class of materials that are used in different scientific fields because of their hybrid structure. In this project, focused on two specific applications, and aim is synthesis of a nanostructure which has antibacterial and photocatalytic activity. ZIF-8 because of its chemical and physical stability has been studied. For improving antibacterial influence and photocatalytic activity, silver nanoparticles are added to the structure. Magnetic nanoparticles covered by silica were used as core to facilitate separation process, ZIF-8 structure was constructed as shell on SiO2@Fe2O3 nano spheres. Magnetic nanoparticles improving stability of ZIF-8 in aqueous solutions. Synthetic nano... 

    Liposome Nanoparticles Synthesis in order to Study the Antibiotic Drug Delivery in Simulated Environment of Body

    , M.Sc. Thesis Sharif University of Technology Bahari, Mohsen (Author) ; Alemzadeh, Iran (Supervisor)
    In recent years, much attention has been paid to the preparation of nanoparticles as carriers for drug delivery. Nanoparticle carriers, by changing the pharmacokinetic properties of the drug, improve the function of the drug and reduce its side effects. In the manufacture of nanoparticles, various materials such as polymers, metal particles, lipids, etc. are used to transfer the drugs, which can produce a different shape and size of the particles depending on their production method. The purpose of this project is the synthesis of liposomal nanoparticles (as nano-carriers) to load an antibiotic (Eucalyptus oil) and study the release of the encapsulated drug in the simulated environment of... 

    Synthesis and Investigation of Antibacterial Activity of Nanostructures Carbon Nitride g-C3N4 Photocatalyst under Visible Light

    , M.Sc. Thesis Sharif University of Technology Ahmadi, Marzie (Author) ; RoustaAzad, Reza (Supervisor) ; Vosoughi, Manouchehr (Supervisor) ; Padervand, Mohsen (Supervisor)
    Carbon nitride is a compound that has the proper energy gap (2.7 eV) for activities in the visible light. In this research, photocatalysts based on nanoporous Carbon nitride sheets was synthesized with three primary ingredient (urea, melamine and melamine hydrochloride) by pyrolysis method. Ag, Cu, Fe2O3 and Fe3O4 were added to the system to prevent the electron-hole recombination as well as increscent the photocatalytic activity. The chemical bonding state properties and microstructure of the synthesized photocatalysts were investigated by means of XRD, SEM, BET, FTIR, DRS and PL methods. In the first step of the research, the activity of prepared compounds was analyzed by visible light for... 

    Antibacterial Activity of Magnetic Fe3O4/X (X=Ag, Cu, Au) Nanocomposites Modified with Ionic Liquid

    , M.Sc. Thesis Sharif University of Technology karimiasl, Moslem (Author) ; Gholami, Mohammad Reza (Supervisor)
    In this thesis, Fe3O4 magnetic nanoparticles were produced using co-precipitation method. The surface of these magnetic nanoparticles is modified by ionic-liquid groups, and then coated with Cu, Au and Ag metals. These nanoparticles were unstable before their surface modification, so that they were easily agglomerated. However, after their surface is modified with ionic-liquid, they become very stable and are easily solved in polar and non-polar solvents. This solubility depends on the alkyls groups connected to the ionic-liquid. Magnetic nano composites Fe3O4/X (X=Ag, Cu, Au) modified by ionic-liquid are prepared by absorbing Cu(NO3)2, HAuClO4 and AgNO3 salts on the surface of modified... 

    Synthesis, Characterization and Applications of Antibacterial Metal-Organic Framework Nanocomposites for Water Remediation

    , M.Sc. Thesis Sharif University of Technology Talebi Deylamani, Sara (Author) ; Borghei, Mehdi (Supervisor) ; Yaghmaei, Soheila (Supervisor) ; Ghobadi Nejad, Zahra (Co-Supervisor)
    Contaminants in drinking water, including microbial contaminants, have a great impact on the health of people in the community and can seriously threaten public health. In recent years, diseases caused by pathogenic bacteria due to the consumption of contaminated water have led to many deaths. As a result, water treatment has been one of the most important human concerns. Among the new water treatment technologies, metal-organic(MOF) frameworks are a new generation of porous materials that have properties such as high surface area, water stability and functionality due to their dual structure. As a result, they are widely used today in various scientific fields, including water purification.... 

    Preparation and optimization of ciprofloxacin encapsulated niosomes: A new approach for enhanced antibacterial activity, biofilm inhibition and reduced antibiotic resistance in ciprofloxacin-resistant methicillin-resistance Staphylococcus aureus

    , Article Bioorganic Chemistry ; Volume 103 , October , 2020 Mirzaie, A ; Peirovi, N ; Akbarzadeh, I ; Moghtaderi, M ; Heidari, F ; Yeganeh, F. E ; Noorbazargan, H ; Mirzazadeh, S ; Bakhtiari, R ; Sharif University of Technology
    Academic Press Inc  2020
    Ciprofloxacin is an alternative to vancomycin for treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections. The objective of this study was to optimization of niosomes encapsulated ciprofloxacin and evaluate their antibacterial and anti-biofilm efficacies against ciprofloxacin-resistant methicillin-resistant S. aureus (CR-MRSA) strains. Formulation of niosomes encapsulated ciprofloxacin were optimized by changing the proportions of Tween 60, Span 60, and cholesterol. The optimized ciprofloxacin encapsulated niosomal formulations based on Span 60 and Tween 60 were prepared and characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM) and... 

    Synthesis of Fe3O4 Core-Shell Nanoparticles; Embedding Cu, Ag, Au Metals in the Surfaces that Were Modified by PPG and PEG Polymers and Investigation of Antibacterial Properties of These Composites

    , M.Sc. Thesis Sharif University of Technology Kiani Karanji, Ahmad (Author) ; Gholami, Mohammad Reza (Supervisor) ; Haghighi, Saeed (Co-Advisor)
    In this project, Fe3O4 magnetic nanoparticles were prepared by co-precipitation method. For protecting them against oxidation and also avoiding from direct contact between core and additional materials that probably makes unwanted reactions, the surface of nanoparticles were coated by SiO2 layer. Being easy to modify and having the control of interactions between nanoparticles are the advantages of coating nanoparticles with silica. The obtained Fe3O4@SiO2 core-shell nanoparticles were covered by two types of polymer (PPG and PEG). The basis of the composite was characterized by VSM, TGA, SEM, XRD, and FT-IR analytical methods.
    The antibacterial activities of Copper, Silver and Gold... 

    Synthesis of Antibacterial Nanoparticle for Packaging Food Application

    , M.Sc. Thesis Sharif University of Technology Radan, Niloofar (Author) ; Yaghmaei, Soheila (Supervisor) ; Ghobadinezhad, Zahra (Co-Supervisor)
    Food spoilage cased by food-borne pathogens and microorganisms is a serious problem in the food and packaging industry. Then, the demand for antibacterial agents in food packaging is growing. The antibacterial efficacy of some nanocomposites has been recognized and exploited in various industries, including the packaging industry. Also, metal organic frameworks due to their porous structure, are used in various fields such as food packaging. The purpose of this work, is synthesize hybrid nanocomposite that have promising antibacterial activity for preparation of food packaging films. Carboxymethyl cellulose is a derivative of cellulose fiber. The use of carboxymethyl cellulose as... 

    Surface modifications of titanium implants by multilayer bioactive coatings with drug delivery potential: antimicrobial, biological, and drug release studies

    , Article JOM ; Volume 68, Issue 4 , 2016 , Pages 1100-1108 ; 10474838 (ISSN) Ordikhani, F ; Petrova Zustiak, S ; Simchi, A ; Sharif University of Technology
    Recent strategies to locally deliver antimicrobial agents to combat implant-associated infections—one of the most common complications in orthopedic surgery—are gaining interest. However, achieving a controlled release profile over a desired time frame remains a challenge. In this study, we present an innovative multifactorial approach to combat infections which comprises a multilayer chitosan/bioactive glass/vancomycin nanocomposite coating with an osteoblastic potential and a drug delivery capacity. The bioactive drug-eluting coating was prepared on the surface of titanium foils by a multistep electrophoretic deposition technique. The adopted deposition strategy allowed for a high... 

    Sustainable release of vancomycin from silk fibroin nanoparticles for treating severe bone infection in rat tibia osteomyelitis model

    , Article ACS Applied Materials and Interfaces ; Volume 9, Issue 6 , 2017 , Pages 5128-5138 ; 19448244 (ISSN) Hassani Besheli, N ; Mottaghitalab, F ; Eslami, M ; Gholami, M ; Kundu, S. C ; Kaplan, D. L ; Farokhi, M ; Sharif University of Technology
    American Chemical Society  2017
    The successful treatment of bone infections is a major challenge in the field of orthopedics. There are some common methods for treating bone infections, including systemic antibiotic administration, local nondegradable drug vehicles, and surgical debridement, and each of these approaches has advantages and disadvantages. In the present study, the antibiotic vancomycin (VANCO) was loaded in silk fibroin nanoparticles (SFNPs) and the complexes were then entrapped in silk scaffolds to form sustained drug delivery systems. The release kinetics of VANCO from SFNPs alone and when the SFNPs were entrapped in silk scaffolds were assessed at two different pH values, 4.5 and 7.4, that affected the... 

    Molecular machinery responsible for graphene oxide's distinct inhibitory effects toward pseudomonas aeruginosa and staphylococcus aureus pathogens

    , Article ACS Applied Bio Materials ; Volume 4, Issue 1 , 2021 , Pages 660-668 ; 25766422 (ISSN) Ashari Astani, N ; Najafi, F ; Maghsoumi, A ; Huma, K ; Azimi, L ; Karimi, A ; Ejtehadi, M. R ; Gumbart, J. C ; Naseri, N ; Sharif University of Technology
    American Chemical Society  2021
    Graphene oxide flakes are considered as potential inhibitors for different pathogenic bacteria. However, the efficacy of inhibition changes for different types and strains of bacteria. In this work, we examine Pseudomonas aeruginosa and Staphylococcus aureus, two common hospital-acquired infections, which react quite differently to graphene oxide flakes. The minimum inhibitory tests yield two distinct outcomes: stopped proliferation for S. aureus versus almost no effect for P. aeruginosa. Integrating our experimental evidence with molecular dynamics simulations, we elucidate the molecular machinery involved, explaining the behavior we see in scanning electron microscopy images. According to... 

    Synthesis of nanostructured Ag@SiO2-Penicillin from high purity Ag NPs prepared by electromagnetic levitation melting process

    , Article Materials Science and Engineering C ; Volume 102 , 2019 , Pages 616-622 ; 09284931 (ISSN) Malekzadeh, M ; Yeung, K. L ; Halali, M ; Chang, Q ; Sharif University of Technology
    Elsevier Ltd  2019
    Nanostructured Ag@SiO2-Penicillin was synthesized from high-purity Ag0 NPs with a mean particle size of about 10 nm produced by electromagnetic levitation gas condensation (ELGC) method. The silver and penicillin contents of the synthesized nano-antibiotic were about 34 wt% and 2.5 wt% respectively, as determined by ICP-OES and TGA analyses. The antibacterial properties and synergistic effects of nanostructured Ag@SiO2 and Ag@SiO2–Penicillin on killing the Methicillin-susceptible S. aureus (MSSA) and Methicillin-resistant S. aureus (MRSA) bacteria were also examined. The nanoparticles were characterized by X-ray diffraction (XRD) and transmission electron microscopy (TEM). Ag@SiO2-Penicillin... 

    Pemphigus vulgaris and infections: A retrospective study on 155 patients

    , Article Autoimmune Diseases ; Volume 2013 , 2013 ; 20900430 (ISSN) Esmaili, N ; Mortazavi, H ; Noormohammadpour, P ; Boreiri, M ; Soori, T ; Vasheghani Farahani, I ; Mohit, M ; Sharif University of Technology
    Background. Autoimmune process and immunosuppressive therapy of pemphigus vulgaris would predispose the patients to infections. Aim. We aimed to study the prevalence of infection and pathogenic agents in pemphigus vulgaris patients admitted to dermatology service. Material and methods. This retrospective study was conducted on 155 pemphigus vulgaris patients (68 males, 87 females) admitted to dermatology service between 2009 and 2011. In this study, the diagnosis of pemphigus vulgaris was confirmed by light microscopic and direct immunofluorescence findings. Data were collected through a questionnaire. Results. Of 155 pemphigus vulgaris patients, 33 had infection at admission and 9 acquired... 

    Novel silver nano-wedges for killing microorganisms

    , Article Materials Research Bulletin ; Volume 46, Issue 11 , 2011 , Pages 1860-1865 ; 00255408 (ISSN) Pourjavadi, A ; Soleyman, R ; Sharif University of Technology
    In the current study, for the first time, photochemical facile green synthesis of salep capped silver nano-wedges was reported via the wet chemical synthesis procedure. Sunlight-UV as an available reducing agent caused mild reduction of silver ions to the silver nano-wedges. Salep as an effective capping/shaping polysaccharide bioresource material was used in the reaction medium and caused creation of flower-like self-assembled structures of the silver nano-wedges. The formation of silver nano-wedges and their flower-like self-assembled structures was confirmed by SEM technique. Further investigations were carried out using UV-vis, FTIR, GPC and XRD data. The prepared silver nano-wedges... 

    Physicochemical and biological properties of electrodeposited graphene oxide/chitosan films with drug-eluting capacity

    , Article Carbon ; Volume 84, Issue C , April , 2015 , Pages 91-102 ; 00086223 (ISSN) Ordikhani, F ; Ramezani Farani, M ; Dehghani, M ; Tamjid, E ; Simchi, A ; Sharif University of Technology
    Elsevier Ltd  2015
    In this study, novel graphene oxide/chitosan nanocomposite coatings with long term drugeluting potential are presented. The coatings are fabricated by the facile and reproducible electrophoretic deposition technique. Analysis of the prepared films shows that the graphene oxide nanosheets are exfoliated in the chitosan matrix. Fourier-transform infrared spectrometry reveals polymer attachment to the carboxylic bonds of graphene oxide, providing a strong interaction and exfoliation of the nanolayers. In vitro viability assay by human osteosarcoma cells (MG-63) demonstrates that the nanocomposite films are highly biocompatible up to 30 wt% graphene oxide, but at higher concentrations a slight... 

    Shape-controlled silver NPs for shape-dependent biological activities

    , Article Micro and Nano Letters ; Volume 12, Issue 9 , 2017 , Pages 647-651 ; 17500443 (ISSN) Sadeghi, F ; Yazdanpanah, A ; Abrishamkar, A ; Moztarzadeh, F ; Ramedani, A ; Pouraghaie, S ; Shirinzadeh, H ; Samadikuchaksaraei, A ; Chauhan, N. P. S ; Hopkinson, L ; Sefat, F ; Mozafari, M ; Sharif University of Technology
    The most important issue during synthesis of nanoparticles (NPs) is to avoid particle agglomeration and adhesion. There have been several attempts to use special substances such as organic surfactants, polymers and stable ligands for this purpose. In this study, silver NPs were synthesised with and without gelatin macromolecules, as a green natural biopolymer, which resulted in NPs with varying shapes and sizes. The effect of morphological characteristics on the antibacterial and antifungal properties of the synthesised NPs were studied, by comparing Gram-negative (Escherichia coli) versus Gram-positive (Staphylococcus aureus) bacteria as well as fungi (Candida albicans) by calculation of... 

    Biodegradation of synthetic dye using partially purified and characterized laccase and its proposed mechanism

    , Article International Journal of Environmental Science and Technology ; Volume 16, Issue 12 , 2019 , Pages 7805-7816 ; 17351472 (ISSN) Ghobadi Nejad, Z ; Borghei, S. M ; Yaghmaei, S ; Sharif University of Technology
    Center for Environmental and Energy Research and Studies  2019
    The supernatant obtained from the extracellular laccase produced by Phanerochaete chrysosporium was used as the enzyme source to conduct a partial purification, characterization and dye decolorization study. The partially purified enzyme was stable in the pH range of 3–5 and showed an optimum activity at pH 4.0, using guaiacol as a substrate. Laccase stability of pH was determined and discovered to retain 100% of its activity at a pH of 4.0 after 2 h. The maximum enzyme activity was obtained between 30 and 50 °C. The maximum velocity and Michaelis constant were calculated as 3.171 µM−1·min and 1628.23 µM, respectively. The enzyme was activated by Fe2+, Zn2+, Ca2+ and Cu2+, while Hg2+, Mn2+,...