Sharif Digital Repository

Random decision making in genetic switches can be modeled as tossing a biased coin. In other word, each genetic switch can be considered as a game in which the reactive elements compete with each other to increase their molecular concentrations. The existence of a very small number of reactive element molecules has caused the neglect of effects of noise to be inevitable. Noise can lead to undesirable cell fate in cellular differentiation processes. In this paper, we study the robustness to noise in genetic switches by considering another switch to have a new gene regulatory network (GRN) in which both switches have been affected by the same noise and for this purpose, we will use Parrondo's... 

This paper presents an improved stochastic simulation method for calculating current dependent energy losses in distribution networks. The method is based on power load curves and integrates the stochastic nature of the load curves with power and voltage covariance matrices. The method reduces calculation effort using the factor analysis of covariance matrices and provides a few quantities needed to calculate energy losses. The method has no limitation for network configuration and gives accurate results several times faster than other existing methods. Therefore, it is appropriate for considering losses in optimization and decision making purposes in operating and planning of distribution... 

As of late, copulas have drawn great attention in stochastic simulation, financial engineering, and risk management. Their power lies under their ability of modeling dependent random variables. Using a known theorem in probability which proves that the fractional part of the sum of a uniform and an arbitrary independent continuous random variable follows a uniform distribution, we construct a wide class of bivariate copulas in which bivariate random vector generation can be performed easily. Some important members of this new class and their properties together with two invariant correlation measures and some insights in their application are presented. © Taylor & Francis Group, LLC  

A new mathematical model for the capacitated multi-facility location-allocation problem with probabilistic customers' locations and demands is developed in this article. The model is formulated into the frameworks of the expected value model (EVM) and the chance-constrained programming (CCP) based on two different distance measures. In order to solve the model, two hybrid intelligent algorithms are proposed, where the simplex algorithm and stochastic simulation are the bases for both algorithms. However, in the first algorithm, named SSGA, a special type of genetic algorithm is combined and in the second, SSVDO, a vibration-damping optimisation (VDO) algorithm is united. The Taguchi method... 

Stochastic simulation is carried out to investigate intracellular viral reaction kinetics and the time evolution of the average particle number ( N̄) and coefficient variation (CV) for genome, template, and structural protein. The coefficient variation of these components is found to be ordered as: CV template > CV structural protein > CVgenome. The average particle number is also calculated via a deterministic approach. The magnitude value of the difference between the stochastic and deterministic approaches is found to be N̄ template ̃ N̄ structural protein > N̄ genome. The Poisson algorithm has been used to investigate the number of particles in the dynamics of intracellular viral... 

A three-dimensional model has been developed to describe the multiphase release of macromolecular drugs encapsulated in a hydrogel. The heterogeneity of network mesh size was considered by assigning varying diffusion coefficients to the network lattices randomly. Using a stochastic approach, the random nature of diffusion of drug molecules was captured within the network. The simplest form of distribution containing two diffusion coefficients was tested. To generate the drug release profiles for experimental validation under the limitation of computational cost, a simple scaling relationship was employed. Unlike the single-diffusivity model, the dual-diffusivity model showed good agreement... 

In this paper, a multiproduct multi-chance constraint stochastic inventory control problem is considered, in which the time-periods between two replenishments are assumed independent and identically distributed random variables. For the problem at hand, the decision variables are of integer-type, the service-level is a chance constraint for each product, and the space limitation is another constraint of the problem. Furthermore, shortages are allowed in the forms of fuzzy random quantities of lost sale that are backordered. The developed mathematical formulation of the problem is shown to be a fuzzy random integer-nonlinear programming model. The aim is to determine the maximum level of... 

This paper proposes a decentralized market-based model for long-term capacity investment decisions in a liberalized electricity market with significant wind power generation. In such an environment, investment and construction decisions are based on price signal feedbacks and imperfect foresight of future conditions in electricity market. System dynamics concepts are used to model structural characteristics of power market such as, long-term firms' behavior and relationships between variables, feedbacks and time delays. For conventional generation units, short-term price feedback for generation dispatching of forward market is implemented as well as long-term price expectation for...