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The effect of mesoporous silica nanoparticle surface chemistry and concentration on the α-synuclein fibrillation
, Article RSC Advances ; Volume 5, Issue 75 , Jul , 2015 , Pages 60966-60974 ; 20462069 (ISSN) ; Morshedi, D ; Doostkam, M ; Yaghmaei, S ; Aliakbari, F ; Singh, G ; Arpanaei, A ; Sharif University of Technology
Royal Society of Chemistry
2015
Abstract
The aggregation of an amyloid protein, α-synuclein (α-Syn), has been suggested as a potential cause of Parkinson's and several other neurodegenerative diseases. To explore the possibility of using nanoparticle-based therapeutic agents for the treatment of such diseases, we investigated the influence of surface chemistry and concentration of mesoporous silica nanoparticles (MSNPs) on the fibrillation of recombinant human α-Syn protein in the present work. Bare MSNPs as well as MSNPs of different surface functionalities, including 3-(2-aminoethyl amino) propyltrimethoxysilane (AAS), succinic anhydride (carboxyl), and polyethyleneimine (PEI) were prepared and characterized by electron...