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sulfanilamide-derivative
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Miniaturized salting-out liquid-liquid extraction in a coupled-syringe system combined with HPLC-UV for extraction and determination of sulfanilamide
, Article Talanta ; Vol. 121 , April , 2014 , pp. 199-204 ; ISSN: 00399140 ; Khosraviani, M ; Sadegh Amini-Fazl, M ; Sharif University of Technology
Abstract
In salting-out liquid-liquid extraction (SALLE) technique, water-miscible organic solvents are used for extraction of polar analytes from saline solutions. In this study, for the first time, a coupled 1-mL syringes system was utilized to perform a miniaturized SALLE method. Sulfanilamide antibiotic was extracted and determined via the developed method followed by high performance liquid chromatography-ultraviolet detection (HPLC-UV). The extraction process was carried out by rapid shooting of acetonitrile as extraction solvent (syringe B) into saline aqueous sample solution (syringe A), and then the shooting was repeated several times at a rate of 1 cycle s-1. Thereby, an extremely large...