Search for: superparamagnetic-iron-oxides
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    Preparation and biological evaluation of [67 Ga]-labeled-superparamagnetic iron oxide nanoparticles in normal rats

    , Article Journal of Nuclear Science and Technology ; Volume 97, Issue 1 , September , 2009 , Pages 51–56 Jalilian, A. R ; Panahifar, A ; Mahmoudi, M. (Morteza) ; Akhlaghi, M. (Mahdi) ; Simchi, A. (Abdolreza) ; Sharif University of Technology
    Gallium-67 labeled superparamagnetic iron oxide nanoparticles were prepared and evaluated for their altered biodistribution in normal rats. Superparamagnetic iron oxide nanoparticles with narrow size distribution were synthesized by co-precipitation technique using ferric and ferrous salts at molar ratio Fe3+/Fe2+=2:1 followed by structure identification using XRD, thermo gravimetric analysis , differential scanning calorimetric , vibrating sample magnetometer, high-resolution scanning electron microscopy,transmission electron microscopy and fourier transform infrared absorption techniques. In order to trace superparamagnetic iron oxide nanoparticles bio-distribution, the radiolabeled iron... 

    Preparation and biological evaluation of [67Ga]-labeled- superparamagnetic nanoparticles in normal rats

    , Article Radiochimica Acta ; Volume 97, Issue 1 , 2009 , Pages 51-56 ; 00338230 (ISSN) Jalilian, A. R ; Panahifar, A ; Mahmoudi, M ; Akhlaghi, M ; Simchi, A ; Sharif University of Technology
    R. Oldenbourg Verlag GmbH  2009
    Gallium-67 labeled superparamagnetic iron oxide nanoparticles ([ 67Ga]-SPION were prepared and evaluated for their altered biodistribution in normal rats. Superparamagnetic iron oxide nanoparticles (SPION) with narrow size distribution were synthesized by a co-precipitation technique using ferrous salts at Fe3+/Fe2+ = 2 molar ratio followed by structure identification using XRD, TGA, DSC, VSM, HRSEM, TEM and FT-IR techniques (≈ 5 nm diameter). In order to trace SPION bio-distribution, the radiolabeled iron oxide nanoparticles were prepared using 67Ga with a high labeling efficiency (over 96%, RTLC method) and they also showed an excellent stability at room temperature for at least 4 d. The... 

    Surface Modification of Super Paramagnetic Iron Oxide Nanoparticles (SPIONs)for Cell Separation

    , M.Sc. Thesis Sharif University of Technology Shirzadeh, Ghazale (Author) ; Maddah Hoseini, Hamid Reza (Supervisor)
    The aim of this project is the surface modification of super para magnetic iron oxide (SPIONs), leading to oriented covalent bonding of antibody(AB) to these nanoparticles (NPs) and improve the efficiency of cell separation at MACS columns. For this purpose, SPIONs synthesized by co-precipitation method, and the stability of colloidal NPs then was provided by coating with Dextran . We used TGA to measure weight percentage of dextran. Some properties like particle size, hydrodynamic diameter, presence of coating and superparamagnetic properties were characterized by XRD (16 nm), FTIR, DLS (73 nm), TEM (20nm) and VSM (≈76/78 emu/g) method, respectively. Then we tried to immobilize AB on NPs... 

    Determination of Protein Absorption Profile at the Surface of Biocompatible Superparamagnetic Iron Oxide Nanoparticles using Gel Electrophoresis

    , M.Sc. Thesis Sharif University of Technology Ghasemi, Forough (Author) ; Hormozi Nezhad, Mohammad Reza (Supervisor) ; Mahmoudi, Morteza (Supervisor)
    Superparamagnetic Iron Oxide NPs (SPIONs) because of their multi-task capabilities (e.g. magnetic labeling, cell isolation, hyperthermiaand controlled drug release) have been recognized as one of the most promising NPs for theranosis applications.When NPs come in contact with a biological medium, the surfaces of them are covered by biomolecules (e.g., proteins, natural organic materials, and enzymes). Therefore, what a biological entity, such as cells, tissues, and organs, sees when interacting with NPs is different original pristine surface of the NPs and actually is hard protein corona. Shape of NPs has a great impact on proteins adsorb onto its surface and consequently on the way that... 

    Cell life cycle effects of bare and coated superparamagnetic iron oxide nanoparticles

    , Article Toxic Effects of Nanomaterials ; 2012 , Pages 53-66 ; 9781608054213 (ISBN) Mahmoudi, M ; Laurent, S ; Journeay, W. S ; Sharif University of Technology
    Due to the hopeful potential of nanoparticles in medicine, they have attracted much attention for various applications such as targeted drug/gene delivery, separation or imaging. Interaction of NPs with the biological environment can lead to a wide range of cellular responses. In order to have safe NPs for biomedical applications, the current biocompatibility researches are particularly focused on the severe toxic mechanisms which cause cells death. These mechanisms are apoptosis, autophagy and necrosis, which can also be intricately linked with the cell-life cycle, as there are various check-points and controls in a cell's life cycle to ensure appropriate division processes. Mechanisms by... 

    Mechanistic understanding of the interactions between nano-objects with different surface properties and α-synuclein

    , Article ACS Nano ; Volume 13, Issue 3 , 2019 , Pages 3243-3256 ; 19360851 (ISSN) Mohammad Beigi, H ; Hosseini, A ; Adeli, M ; Ejtehadi, M. R ; Christiansen, G ; Sahin, C ; Tu, Z ; Tavakol, M ; Dilmaghani Marand, A ; Nabipour, I ; Farzadfar, F ; Otzen, D. E ; Mahmoudi, M ; Hajipour, M. J ; Sharif University of Technology
    American Chemical Society  2019
    Aggregation of the natively unfolded protein α-synuclein (α-syn) is key to the development of Parkinson's disease (PD). Some nanoparticles (NPs) can inhibit this process and in turn be used for treatment of PD. Using simulation strategies, we show here that α-syn self-assembly is electrostatically driven. Dimerization by head-to-head monomer contact is triggered by dipole-dipole interactions and subsequently stabilized by van der Waals interactions and hydrogen bonds. Therefore, we hypothesized that charged nano-objects could interfere with this process and thus prevent α-syn fibrillation. In our simulations, positively and negatively charged graphene sheets or superparamagnetic iron oxide... 

    Preparation and Evaluation of Doxorubicin-loaded Fe3O4\Chitosan Magnetic Nanocomposite for Drug Delivery System in Cancer Therapy

    , M.Sc. Thesis Sharif University of Technology Tajeri, Razieh (Author) ; Maddah Hosseini, Hamid Reza (Supervisor)
    Recent drug delivery strategies have attempted to maximize the concentration of chemotherapeutic molecules into the tumors, while minimizing their systemic distribution. Doxorubicin has been widely used for a variety of cancers, successfully producing regression in acute leukaemia, lymphomas, soft-tissue and osteogenic sarcomas, paediatric malignancies and adult solid tumours, in particular breast and lung carcinomas. Common adverse effects of doxorubicin include hair loss, myelosuppression, nausea and vomiting, oral mucositis, oesophagitis, diarrhoea, skin reactions and serious reactions include hypersensitivity reactions, radiation recall, heart damage and liver dysfunction. Chitosan has... 

    Synthesis and Characterization of Dextran Based Magnetic Nanogels as a Gene Delivery Vector and Investigating its Gene Therapy Efficiency

    , M.Sc. Thesis Sharif University of Technology Azadpour, Behnam (Author) ; Madaah Hosseini, Hamid Reza (Supervisor) ; Arefian, Ehsan (Supervisor)
    The use of magnetic nanoparticles modified with proper surface agent and the ability of controlling by magnetic field, that can induce colloidal stability, is considered as a vector to transfer DNA plasmid, or pDNA in short, in the field of gene therapy. In thiss research, pH-responsive dextran-based magnetic nanogels (dextMNGs) were synthesized via inverse mini-emulsion method. Fourier transformation infrared spectroscopy (FTIR) showed that magnetite nanoparticles (MNPs) were successfully modified with arginine and had amine terminals. FTIR, also, proved that aldehyded dextran was crosslinked by arginine modified magnetite nanoparticles (RMNPs) via pH sensitive imine bonds. X-ray... 

    Magnetite/dextran-functionalized graphene oxide nanosheets for in vivo positive contrast magnetic resonance imaging

    , Article RSC Advances ; Volume 5, Issue 59 , May , 2015 , Pages 47529-47537 ; 20462069 (ISSN) Moradi, S ; Akhavan, O ; Tayyebi, A ; Rahighi, R ; Mohammadzadeh, M ; Saligheh Rad, H. R ; Sharif University of Technology
    Royal Society of Chemistry  2015
    Superparamagnetic iron oxide (SPIO) nanomaterials are widely used as magnetic resonance imaging (MRI) contrast agents (CAs). These CAs significantly shorten transverse relaxation time (T2) and so decrease the intensity of the T2-weighted MRI (negative contrast imaging). However, the partial-volume effect is known to be one of the problems in negative contrast MRI. In this work, SPIO nanoparticles were modified by dextran and graphene oxide (GO) nanosheets to achieve a positive contrast MRI with high intensity. This modification resulted in shortening the longitudinal relaxation time (T1) of the SPIO nanoparticles (in addition to the T2 shortening).... 

    Magnetic pH-responsive nanocarrier with long spacer length and high colloidal stability for controlled delivery of doxorubicin

    , Article Colloids and Surfaces B: Biointerfaces ; Vol. 116 , April , 2014 , pp. 49-54 ; ISSN: 09277765 Pourjavadi, A ; Hosseini, S. H ; Alizadeh, M ; Bennett, C ; Sharif University of Technology
    A novel magnetic nanocarrier with long spacer length and high colloidal stability has been prepared for effective delivery of doxorubicin (DOX). First, poly(amidoamine) (PAMAM) dendrimer was grown up onto the surface of superparamagnetic iron oxide nanoparticles to increase the loading amount of amine groups. Then, terminal amine groups were functionalized by polyethylene glycol dimethylester to increase the spacer length. Then anticancer drug DOX was covalently attached onto the system by hydrazone bond to forms a pH-sensitive nanocarrier. This system is designed to combine the advantage of magnetic targeting, high drug loading capacity, and controlled release  

    Synthesis of pseudopolyrotaxanes-coated superparamagnetic Iron oxide nanoparticles as new MRI contrast agent

    , Article Colloids and Surfaces B: Biointerfaces ; Volume 103 , March , 2013 , Pages 652-657 ; 09277765 (ISSN) Hosseini, F ; Panahifar, A ; Adeli, M ; Amiri, H ; Lascialfari, A ; Orsini, F ; Doschak, M. R ; Mahmoudi, M ; Sharif University of Technology
    Superparamagnetic Iron Oxide Nanoparticles (SPIONs) were synthesized and coated with pseudopolyrotaxanes (PPRs) and proposed as a novel hybrid nanostructure for medical imaging and drug delivery. PPRs were prepared by addition of α-cyclodextrin rings to functionalized polyethylene glycol (PEG) chain with hydrophobic triazine end-groups. Non-covalent interactions between SPIONs and PPRs led to the assembly of SPIONs@PRs hybrid nanomaterials. Measurements of the 1H Nuclear Magnetic Resonance (NMR) relaxation times T1 and T2 allowed us to determine the NMR dispersion profiles. Comparison between our SPIONs@PRs hybrid nano-compound and the commercial SPION compound, Endorem®, showed a higher... 

    Evaluation of radiogallium-labeled, folate-embedded superparamagnetic nanoparticles in fibrosarcoma-bearing mice

    , Article Journal of Cancer Research and Therapeutics ; Volume 8, Issue 2 , 2012 , Pages 204-208 ; 09731482 (ISSN) Hosseini Salekdeh, S. L ; Jalilian, A.R ; Yousefnia, H ; Shafaii, K ; Pouladian, M ; Mahmoudi, M ; Sharif University of Technology
    Context: Elevated expression of the folate receptor (FR) occurs in many human malignancies. Thus, folate targeting is widely utilized in drug delivery purposes specially using nano-radioactive agents. Aims: In this work, we report production and biological evaluation of gallium-67 labeled superparamagnetic iron oxide nanoparticles, embedded by folic acid (67 Ga-SPION-folate) complex especially in tumor-bearing mice for tumor imaging studies. Settings and Design: The structure of SPION-folate was confirmed by X-ray diffraction (XRD), transmission electron microscopy (TEM) and foureir transform infrared spectroscopy (FT-IR) analyses. The radiolabeled SPION-folate formation was confirmed by... 

    A new approach for the in vitro identification of the cytotoxicity of superparamagnetic iron oxide nanoparticles

    , Article Colloids and Surfaces B: Biointerfaces ; Volume 75, Issue 1 , 2010 , Pages 300-309 ; 09277765 (ISSN) Mahmoudi, M ; Simchi, A ; Imani, M ; Shokrgozar, M. A ; Milani, A. S ; Häfeli, U. O ; Stroeve, P ; Sharif University of Technology
    Superparamagnetic iron oxide nanoparticles (SPIONs) are increasingly used in medical applications, such as targeting delivery and imaging. In the future, patients are more likely to be exposed to pharmaceutical products containing such particles. The study of toxicity of SPIONs has become of great importance in recent years, although the published data in this arena is limited. The aim of the present work is to investigate the cytotoxicity of SPIONs and the effect of the particles on the cell medium components. For this purpose, uncoated and polyvinyl alcohol (PVA) coated SPIONs with narrow size distribution were synthesized via a well-known coprecipitation method. The mouse fibroblast cell... 

    Multiphysics flow modeling and in vitro toxicity of iron oxide nanoparticles coated with poly(vinyl alcohol)

    , Article Journal of Physical Chemistry C ; Volume 113, Issue 6 , 2009 , Pages 2322-2331 ; 19327447 (ISSN) Mahmoudi, M ; Shokrgozar, M. A ; Simchi, A ; Imani, M ; Milani, A. S ; Stroeve, P ; Vali, H ; Häfeli, U. O ; Bonakdar, S ; Sharif University of Technology
    This study investigated the behavior of ferrofluids containing superparamagnetic iron oxide nanoparticles (SPION) of various compositions for potential applications in drug delivery and imaging. To ensure biocompatibility, the interaction of these SPION with two cell lines (adhesive and suspended) was also investigated using an MTT (3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide) assay. The cell lines studied were primary mouse connective tissue cells (adhesive) and human leukemia cells (suspended). SPION were synthesized with a co-precipitation method under different stirring rates and NaOH molarities. The SPION demonstrated a range of magnetic saturations due to their... 

    Evaluating the effect of ultrasmall superparamagnetic iron oxide nanoparticles for a long-term magnetic cell labeling

    , Article Journal of Medical Physics ; Volume 38, Issue 1 , 2013 , Pages 34-40 ; 09716203 (ISSN) Shanehsazzadeh, S ; Oghabian, M. A ; Allen, B. J ; Amanlou, M ; Masoudi, A ; Daha, F. J ; Sharif University of Technology
    In order to evaluate the long-term viability, the iron content stability, and the labeling efficiency of mammalian cells using magnetic cell labeling; dextran-coated ultrasmall superparamagnetic iron oxide (USPIOs) nanoparticles with plain surfaces having a hydrodynamic size of 25 nm were used for this study. Tests were carried out in four groups each containing 5 flasks of 5.5 × 10 6 AD-293 embryonic kidney cells. The cell lines were incubated for 24 h using four different iron concentrations with and without protamine sulfate (Pro), washed with phosphate-buffered saline (PBS) and centrifuged three times to remove the unbounded USPIOs. Cell viability was also verified using USPIOs. There... 

    Preconcentration and determination of pantoprazole by solid-phase extraction coupled with spectrophotometry using iron oxide nanoparticles modified with cetyltrimethylammonium bromide

    , Article Nano Biomedicine and Engineering ; Volume 7, Issue 3 , 2015 , Pages 102-110 ; 21505578 (ISSN) Sayyahmanesh, M ; Naghian, E ; Sahebi, H ; Asgari, S ; Sharif University of Technology
    Open Access House of Science and Technology  2015
    Solid phase extraction coupled with spectrophotometric detection was applied to trace amounts of Pantoprazole (PP) drug using Cetyltrimethylammonium bromide coated-iron oxide magnetite nanoparticles CTAB@Fe3O4 MNPs. After characterization of the prepared nano-adsorbents, experimental parameters affecting the extraction efficiency of the developed method were optimized. The results obtained showed that this proposed approach is applicable in concentrations ranging from 0.1 to 1.5 μg/ml (R2 = 0.9958) indicating that follows Beer's-Lambert law. The limit of detection and the limit of quantification calculated to be 0.014 and 0.04 μg/ml, respectively. The repeatability of the proposed method was... 

    کلیدواژه های تکراریCurcumin loading potentiates the neuroprotective efficacy of Fe3O4 magnetic nanoparticles in cerebellum cells of schizophrenic rats

    , Article Biomedicine and Pharmacotherapy ; Volume 108 , 2018 , Pages 1244-1252 ; 07533322 (ISSN) Naserzadeh, P ; Ashrafi Hafez, A ; Abdorahim, M ; Abdollahifar, M. A ; Shabani, R ; Peirovi, H ; Simchi, A ; Ashtari, K ; Sharif University of Technology
    Background: The aim of this study was to investigate the neurotoxic effects of Fe3O4 magnetic- CurNPs on isolated schizophrenia mitochondria of rats as an in vivo model. Methods: We designed CMN loaded superparamagnetic iron oxide nanoparticles (SPIONs) (Fe3O4 magnetic- CurNPs) to achieve an enhanced therapeutic effect. The physicochemical properties of Fe3O4 magnetic- CurNPs were characterized using X-ray diffraction (XRD), and dynamic laser light scattering (DLS) and zeta potential. Further, to prove Fe3O4 magnetic- CurNPs results in superior therapeutic effects, and also, the mitochondrial membrane potential collapse, mitochondrial complex II activity, reactive oxygen species generation,... 

    Superparamagnetic iron oxide nanoparticles with rigid cross-linked polyethylene glycol fumarate coating for application in imaging and drug delivery

    , Article Journal of Physical Chemistry C ; Volume 113, Issue 19 , 2009 , Pages 8124-8131 ; 19327447 (ISSN) Mahmoudi, M ; Simchi, A ; Imani, M ; Hafeli, U. O ; Sharif University of Technology
    Superparamagnetic iron oxide nanoparticles with proper surface coatings are increasingly being evaluated for clinical applications such as hyperthermia, drug delivery, magnetic resonance imaging, transfection, and cell/protein separation. To enhance the applicability of magnetic nanoparticles, two main problems must be overcome. First, as the drug coats the particle surface, a significant portion of it is quickly released upon injection (burst effect). Therefore, only small amounts of the drug reach the specific site after, for example, magnetic drug targeting. Second, once the surface-derivatized nanoparticles are inside the cells, the coating is likely digested, leaving the bare particles... 

    Synthesizing efficacious genistein in conjugation with superparamagnetic Fe3O4 decorated with bio-compatible carboxymethylated chitosan against acute leukemia lymphoma

    , Article Biomaterials Research ; Volume 24, Issue 1 , 2020 Ghasemi Goorbandi, R ; Mohammadi, M. R ; Malekzadeh, K ; Sharif University of Technology
    BioMed Central Ltd  2020
    Background: Genistein (C15H10O5) is a soy isoflavone with anti-cancer properties such as inhibition of cell growth, proliferation and tumor invasion, but effective dosage against hematopoietic malignant cells was not in non-toxic range. This property cause to impede its usage as chemotherapeutic agent. Therefore, this hypothesis raised that synthesizing biocompatible nanoparticle could assist to prevail this struggle. Methods: Genistein covalently attached on Fe3O4 nanoparticles decorated with carboxymethylated chitosan to fabricate Fe3O4-CMC-genistein in alkaline circumstance. This obtained nanoparticles were evaluated by TEM, DLS, FTIR, XRD and VSM and its anti-cancer effect by growth rate... 

    Synthesis of magnesium-based Janus micromotors capable of magnetic navigation and antibiotic drug incorporation

    , Article New Journal of Chemistry ; Volume 44, Issue 17 , 2020 , Pages 6947-6957 Paryab, A ; Madaah Hosseini, H. R ; Abedini, F ; Dabbagh, A ; Sharif University of Technology
    Royal Society of Chemistry  2020
    In the present study, bubble-driven magnesium-based micromotors were fabricated through a shading method, and the potential of magnetic guidance of magnesium-based Janus micro/nanomotors through functionalization with superparamagnetic iron oxide nanoparticles (SPIONs) was investigated for the first time. SPIONs had physical electrostatic attraction with the positively charged magnesium spheres due to negative charges on their surfaces. It was also found that upon applying a field gradient, the micromotors’ velocity increased by 13% unlike other magnetically navigated spherical magnesium-based micromotors which only show a change in direction. In this work the cytotoxicity of the moving...