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    Commercial zinc oxide: a facile, efficient, and eco-friendly catalyst for the one-pot three-component synthesis of multisubstituted 2-aminothiophenes via the Gewald reaction

    , Article Industrial and Engineering Chemistry Research ; Volume 51, Issue 44 , October , 2012 , Pages 14577-14582 ; 08885885 (ISSN) Tayebee, R ; Ahmadi, S. J ; Rezaei Seresht, E ; Javadi, F ; Yasemi, M. A ; Hosseinpour, M ; Maleki, B ; Sharif University of Technology
    An eco-friendly, simple, and effective protocol is developed for the synthesis of various multisubstituted 2-aminothiophenes. In the presence of a catalytic amount of ZnO (5 mol), ketones or aldehydes, malononitrile and elemental sulfur were converted to the corresponding 2-aminothiophene derivatives in moderate to high yields (27%-70%) under solvent-free conditions at 100 °C. Zinc oxide as an efficient, readily available, and reusable catalyst, showed very good catalytic activity for the synthesis of 2-aminothiophene derivatives. Thus far, little research has been reported on the Gewald reaction under solvent-free conditions; to the best of our knowledge, this is the first time that it has... 

    Crosslinked poly(ionic liquid) as high loaded dual acidic organocatalyst

    , Article Journal of Molecular Catalysis A: Chemical ; Volume 365 , 2012 , Pages 55-59 ; 13811169 (ISSN) Pourjavadi, A ; Hosseini, S. H ; Soleyman, R ; Sharif University of Technology
    A dual acidic heterogeneous organocatalyst was synthesized by copolymerization of acidic ionic liquid monomer (vinyl-3-(3-sulfopropyl) imidazolium hydrogen sulfate [VSim][HSO 4]) and ionic liquid crosslinker (1,4-butanediyl-3,3′-bis-l-vinyl imidazolium dihydrogen sulfate). The resulting ionic heterogeneous catalyst is shown to be an efficient dual acidic organocatalyst for synthesis of dihydropyrimidines using the Biginelli synthetic route under mild reaction conditions in high yields. Since monomers make the catalyst bed, crosslinked poly(ionic liquid) will have high loading level of acidic groups comparing to other heterogeneous acid catalysts. Despite of conventional heterogeneous ionic... 

    Superparamagnetic iron oxide nanoparticles (SPIONs): Development, surface modification and applications in chemotherapy

    , Article Advanced Drug Delivery Reviews ; Volume 63, Issue 1-2 , January–February , 2011 , Pages 24-46 ; 0169409X (ISSN) Mahmoudi, M ; Sant, S ; Wang, B ; Laurent, S ; Sen, T ; Sharif University of Technology
    At present, nanoparticles are used for various biomedical applications where they facilitate laboratory diagnostics and therapeutics. More specifically for drug delivery purposes, the use of nanoparticles is attracting increasing attention due to their unique capabilities and their negligible side effects not only in cancer therapy but also in the treatment of other ailments. Among all types of nanoparticles, biocompatible superparamagnetic iron oxide nanoparticles (SPIONs) with proper surface architecture and conjugated targeting ligands/proteins have attracted a great deal of attention for drug delivery applications. This review covers recent advances in the development of SPIONs together...