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    Preparing a Coated Tablet of Vitamin C

    , M.Sc. Thesis Sharif University of Technology Rastegar, Mehrnoush (Author) ; Alemzadeh, Iran (Supervisor)
    Vitamin C is one of the essential ingredients for the survival of human beings, animals and plants. This vitamin is an ester that in its structure there is a cyclic ester, an alkene Factor (C = C) and four hydroxyl factor (OH). This vitamin is a white solid, water-soluble and non-toxic that exists in many fruits, especially citrus. Its presence in the diet of human resistance them against infections increases. The main factor causing acidic property in vitamin C is the presence of OH groups attached to the alkene. Various forms of vitamin C exists in pharmaceutical collection of European countries. Since the tablet form because of the many advantages including being economical compared with... 

    Voltammetric studies of sumatriptan on the surface of pyrolytic graphite electrode modified with multi-walled carbon nanotubes decorated with silver nanoparticles

    , Article Talanta ; Volume 80, Issue 1 , 2009 , Pages 31-38 ; 00399140 (ISSN) Ghalkhani, M ; Shahrokhian, S ; Ghorbani Bidkorbeh, F ; Sharif University of Technology
    Multi-walled carbon nanotube decorated with silver nanoparticles (AgNPs-MWCNT) is used as an effective strategy for modification of the surface of pyrolytic graphite electrode (PGE). This modification procedure improved colloidal dispersion of the decorated MWCNTs in water, affording uniform and stable thin films for altering the surface properties of the working electrode. Robust electrode for sensing applications is obtained in a simple solvent evaporation process. The electrochemical behavior of sumatriptan (Sum) at the bare PGE and AgNPs-MWCNT modified PGE is investigated. The results indicate that the AgNPs-MWCNT modified PGE significantly enhanced the oxidation peak current of Sum. A... 

    Artificial neural network assisted kinetic spectrophotometric technique for simultaneous determination of paracetamol and p-aminophenol in pharmaceutical samples using localized surface plasmon resonance band of silver nanoparticles

    , Article Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy ; Volume 138 , March , 2015 , Pages 474-480 ; 13861425 (ISSN) Khodaveisi, J ; Dadfarnia, S ; Haji Shabani, A. M ; Rohani Moghadam, M ; Hormozi Nezhad, M. R ; Sharif University of Technology
    Elsevier  2015
    Spectrophotometric analysis method based on the combination of the principal component analysis (PCA) with the feed-forward neural network (FFNN) and the radial basis function network (RBFN) was proposed for the simultaneous determination of paracetamol (PAC) and p-aminophenol (PAP). This technique relies on the difference between the kinetic rates of the reactions between analytes and silver nitrate as the oxidizing agent in the presence of polyvinylpyrrolidone (PVP) which is the stabilizer. The reactions are monitored at the analytical wavelength of 420 nm of the localized surface plasmon resonance (LSPR) band of the formed silver nanoparticles (Ag-NPs). Under the optimized conditions, the... 

    Electrocatalytic determination of sumatriptan on the surface of carbon-paste electrode modified with a composite of cobalt/Schiff-base complex and carbon nanotube

    , Article Bioelectrochemistry ; Volume 81, Issue 2 , 2011 , Pages 81-85 ; 15675394 (ISSN) Amiri, M ; Pakdel, Z ; Bezaatpour, A ; Shahrokhian, S ; Sharif University of Technology
    The electrochemical oxidation of sumatriptan on the surface of carbon paste electrode modified with multi-walled carbon nanotube and cobalt methyl-salophen complex is studied by using cyclic voltammetry and polarization studies. The results indicate that the drug is irreversibly oxidized in a one electron oxidation mechanism. It was found that the peak potential shifted negatively with increasing pH, confirms that H + participate in the oxidation process. The electrode is shown to be very effective for the detection of sumatriptan in the presence of other biological reductant compounds. The prepared modified electrode exhibits a very good resolution between the voltammetric peaks of... 

    Reducing the risk of death induced by aluminum phosphide poisoning: The new therapies

    , Article Chemosphere ; Volume 294 , 2022 ; 00456535 (ISSN) Naddafi, M ; Abouei Mehrizi, A ; Eghbal, M. A ; Ghazi Khansari, M ; Azarmi, Y ; Sattari, M. R ; Karaman, C ; Karimi, F ; Alizadeh, M ; Yazdani, M. N ; Hosseinpour, P ; Sharif University of Technology
    Elsevier Ltd  2022
    Numerous people suffer from accidental or deliberate exposure to different pesticides when poisoning with aluminum phosphate (AlP) is increasing in the eastern countries. Aluminum phosphate is a conventional insecticide that quickly reacts with water or the moistures in the atmosphere and produces fatal phosphine gas, which absorbs quickly by the body. Oral consumption or inhalation of AlP leads to excessive reaction of the body such as fatigue, vomiting, fever, palpitation, vasodilatory shock, increasing blood pressure, cardiac dysfunction, pulmonary congestion, shortness of breath, and death. The garlic smell from the patient's mouth or exhale is one of the methods to recognize the... 

    Challenges and future prospects for the delivery of biologics: oral mucosal, pulmonary, and transdermal routes

    , Article AAPS Journal ; Volume 19, Issue 3 , 2017 , Pages 652-668 ; 15507416 (ISSN) Morales, J. O ; Fathe, K. R ; Brunaugh, A ; Ferrati, S ; Li, S ; Montenegro Nicolini, M ; Mousavikhamene, Z ; McConville, J. T ; Prausnitz, M. R ; Smyth, H. D. C ; Sharif University of Technology
    Springer New York LLC  2017
    Biologic products are large molecules such as proteins, peptides, nucleic acids, etc., which have already produced many new drugs for clinical use in the last decades. Due to the inherent challenges faced by biologics after oral administration (e.g., acidic stomach pH, digestive enzymes, and limited permeation through the gastrointestinal tract), several alternative routes of administration have been investigated to enable sufficient drug absorption into systemic circulation. This review describes the buccal, sublingual, pulmonary, and transdermal routes of administration for biologics with relevant details of the respective barriers. While all these routes avoid transit through the...