Loading...
Search for:
tcga
0.004 seconds
A novel panel of blood-based microRNAs capable of discrimination between benign breast disease and breast cancer at early stages
, Article RNA Biology ; 2021 ; 15476286 (ISSN) ; Kamal, A ; Ahmadi, M ; Najafi, H ; Sharifi Zarchi, A ; Haddad, P ; Shayestehpour, B ; Kamkar, L ; Salamati, M ; Geranpayeh, L ; Lashkari, M ; Totonchi, M ; Sharif University of Technology
Taylor and Francis Ltd
2021
Abstract
Breast cancer (BC) as a leading cause of cancer death among women, exhibits a wide range of genetic heterogeneity in affected individuals. Satisfactory management of BC depends on early diagnosis and proper monitoring of patients’ response to therapy. In this study, we aimed to assess the relation between the expression patterns of blood-based microRNAs (miRNAs) with demographic characteristics of the patients with BC in an attempt to find novel diagnostic markers for BC with acceptable precision in clinical applications. To this end, we performed comprehensive statistical analysis of the data of the Cancer Genome Atlas (TCGA) database and the blood miRNome dataset (GSE31309). As a result,...