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thermo-responsive-copolymers
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Dual-sensitive hydrogel nanoparticles based on conjugated thermoresponsive copolymers and protein filaments for triggerable drug delivery
, Article ACS Applied Materials and Interfaces ; Volume 10, Issue 23 , 17 May , 2018 , Pages 19336-19346 ; 19448244 (ISSN) ; Eslahi, N ; Tamjid, E ; Simchi, A ; Sharif University of Technology
American Chemical Society
2018
Abstract
In this study, novel hydrogel nanoparticles with dual triggerable release properties based on fibrous structural proteins (keratin) and thermoresponsive copolymers (Pluronic) are introduced. Nanoparticles were used for curcumin delivery as effective and safe anticancer agents, the hydrophobicity of which has limited their clinical applications. A drug was loaded into hydrogel nanoparticles by a single-step nanoprecipitation method. The drug-loaded nanoparticles had an average diameter of 165 and 66 nm at 25 and 37 °C, respectively. It was shown that the drug loading efficiency could be enhanced through crosslinking of the disulfide bonds in keratin. Crosslinking provided a targeted release...