Search for: thermosensitive-chitosan-hydrogel
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    Preparation and characterization of a composite biomaterial including starch micro/nano particles loaded chitosan gel

    , Article Carbohydrate Polymers ; Volume 174 , 2017 , Pages 633-645 ; 01448617 (ISSN) Dehghan Baniani, D ; Bagheri, R ; Solouk, A ; Sharif University of Technology
    Thermosensitive Chitosan hydrogels which can be injected into defects with minimally invasive approach were prepared. Also starch micro/nano particles were synthesized via water-in-oil (W/O) miniemulsion technique. The starch particles were incorporated into the chitosan hydrogel to prepare injectable thermosensitive hydrogel composites. Tube inverting method, compression tests, swelling studies, XRD, SEM, OM, DLS, UV–vis spectroscopy were used for investigations. Results revealed that increasing crosslinker and surfactant contents and stirring rate leads to particle size reduction. Particle size was modeled using design of experiments (DOE) via the response surface method (RSM). Due to... 

    Injectable in situ forming kartogenin-loaded chitosan hydrogel with tunable rheological properties for cartilage tissue engineering

    , Article Colloids and Surfaces B: Biointerfaces ; Volume 192 , 2020 Dehghan-Baniani, D ; Chen, Y ; Wang, D ; Bagheri, R ; Solouk, A ; Wu, H ; Sharif University of Technology
    Elsevier B.V  2020
    Limited regeneration capacity of cartilage can be addressed by tissue engineering approaches including localized delivery of bioactive agents using biomaterials. Although chitosan hydrogels have been considered as appropriate candidates for these purposes, however, their poor mechanical properties limit their real applications. Here, we develop in situ forming chitosan hydrogels with enhanced shear modulus by chemical modification of chitosan using N-(β-maleimidopropyloxy) succinimide ester (BMPS). Moreover, we utilize β-Glycerophosphate (β-GP) in the hydrogels for achieving thermosensitivity. We investigate the effects of BMPS, β-GP and chitosan concentration on rheological and swelling...