Sharif Digital Repository

A thermosensitive copolymer was synthesized by graft copolymerization of poly(lactide-co-glycolide) (PLGA) copolymers onto the surface of chitosan membranes. Acryloyl chloride was used as a coupling reagent for the covalent attachment of PLGA to the chitosan membranes. FTIR spectroscopy and DSC analysis were used to characterize the resulting graft copolymer. Thermosensitive swelling behaviors of the copolymer were investigated as well. The membranes exhibited reversible swelling-shrinking behavior; higher swelling ratios were obtained observed at higher temperatures. Drug permeation studies were carried out using vancomycin hydrochloride and betamethasone sodium phosphate as the model...